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Q8V3R4

- PAP1_SWPV1

UniProt

Q8V3R4 - PAP1_SWPV1

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Swinepox virus (strain Swine/Nebraska/17077-99/1999) (SWPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei192 – 1921By similarity
    Active sitei194 – 1941By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    Ordered Locus Names:SPV030
    OrganismiSwinepox virus (strain Swine/Nebraska/17077-99/1999) (SWPV)
    Taxonomic identifieri300880 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000000871: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308940Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8V3R4.
    SMRiQ8V3R4. Positions 8-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8V3R4-1 [UniParc]FASTAAdd to Basket

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    MNRQIANILE NYLGRYPSLN EYHTLKSQYR NIQKVNIFNK DIFISLLRKN    50
    KKKFFSDLVC TQSDIKHSVL SYFSKQENTY SIGKLYTIIE LQTILVTTYT 100
    DVLGVLTTKG PDIFSSTIYY NISSIKKLAT DIVHAMMITT VSDKIMGRHN 150
    VSSLVGNVNT LMEEYLRRHN KNCICYGSYS LHLLNPDVRY GDIDILQTNS 200
    RTFLIDLAFL IKFITGYNVV LLKVPYLKNY MVLKDHNDNH IIDSFNIRQD 250
    TMETIPKILI DNIYIVDPVL QLMSMLKMFS QIDRLEDIVK NPDKVIIRLA 300
    TLLEYVRINY GIILNGDHGN MPMLSTFNHD QRIITVQTNM YNFPFKKCFI 350
    YLDENTLSRD ILHLNADDAV DFENVSNSAY LIHNDTMYTY FSNTILLRSE 400
    NEIHEISTRA ISAHILLYQI LTKGDIIQPL SDIINSLISI EKCTIYKVIQ 450
    RDKKTGKHGI IDIEKDIITH 470
    Length:470
    Mass (Da):54,520
    Last modified:March 1, 2002 - v1
    Checksum:iA4E8243F7690846F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF410153 Genomic DNA. Translation: AAL69769.1.
    RefSeqiNP_570190.1. NC_003389.1.

    Genome annotation databases

    GeneIDi932422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF410153 Genomic DNA. Translation: AAL69769.1 .
    RefSeqi NP_570190.1. NC_003389.1.

    3D structure databases

    ProteinModelPortali Q8V3R4.
    SMRi Q8V3R4. Positions 8-468.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 932422.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPAP1_SWPV1
    AccessioniPrimary (citable) accession number: Q8V3R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3