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Q8UYL3

- Q8UYL3_9POXV

UniProt

Q8UYL3 - Q8UYL3_9POXV

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Protein
Submitted name:

CrmE protein

Gene

crmE

Organism
Vaccinia virus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
CrmE proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:crmEImported
ORF Names:List195Imported, m8259RImported, mO259RImported, W86/88-1-195Imported
OrganismiVaccinia virusImported
Taxonomic identifieri10245 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 36Combined sources
Disulfide bondi37 ↔ 50Combined sources
Disulfide bondi40 ↔ 58Combined sources
Disulfide bondi61 ↔ 76Combined sources
Disulfide bondi79 ↔ 93Combined sources
Disulfide bondi83 ↔ 101Combined sources
Disulfide bondi103 ↔ 121Combined sources
Disulfide bondi109 ↔ 118Combined sources
Disulfide bondi127 ↔ 144Combined sources

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFP013753EBI-7539950,EBI-359977From a different organism.

Protein-protein interaction databases

IntActiQ8UYL3. 1 interaction.
MINTiMINT-6740381.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UWIX-ray2.00A/B22-153[»]
SMRiQ8UYL3. Positions 22-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8UYL3.

Family & Domainsi

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UYL3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKVIIILGF LIINTNSLSM KCEQGVSYYN SQELKCCKLC KPGTYSDHRC
60 70 80 90 100
DKYSDTICGH CPSDTFTSIY NRSPWCHSCR GPCGTNRVEV TPCTPTTNRI
110 120 130 140 150
CHCDSNSYCL LKASDGNCVT CAPKTKCGRG YGKKGEDEMG NTICKKCRKG
160
TYSDIVSDSD QCKPMTR
Length:167
Mass (Da):18,510
Last modified:March 1, 2002 - v1
Checksum:i3B4A0D4A27FB797D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY678275 Genomic DNA. Translation: AAW23648.1.
AY678277 Genomic DNA. Translation: AAW23930.1.
DQ121394 Genomic DNA. Translation: ABD52700.1.
KF866253 Genomic DNA. Translation: AHB23632.1.
AJ315962 Genomic DNA. Translation: CAC83048.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY678275 Genomic DNA. Translation: AAW23648.1 .
AY678277 Genomic DNA. Translation: AAW23930.1 .
DQ121394 Genomic DNA. Translation: ABD52700.1 .
KF866253 Genomic DNA. Translation: AHB23632.1 .
AJ315962 Genomic DNA. Translation: CAC83048.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2UWI X-ray 2.00 A/B 22-153 [» ]
SMRi Q8UYL3. Positions 22-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8UYL3. 1 interaction.
MINTi MINT-6740381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q8UYL3.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00020. TNFR_c6. 1 hit.
[Graphical view ]
SMARTi SM00208. TNFR. 3 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vaccinia virus CrmE encodes a soluble and cell surface tumor necrosis factor receptor that contributes to virus virulence."
    Reading P.C., Khanna A., Smith G.L.
    Virology 292:285-298(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: USSRImported.
  2. "An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection."
    Morikawa S., Sakiyama T., Hasegawa H., Saijo M., Maeda A., Kurane I., Maeno G., Kimura J., Hirama C., Yoshida T., Asahi-Ozaki Y., Sata T., Kurata T., Kojima A.
    J. Virol. 79:11873-11891(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LC16m8Imported and LC16mOImported.
  3. "Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses."
    Garcel A., Crance J.M., Drillien R., Garin D., Favier A.L.
    J. Gen. Virol. 88:1906-1916(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ListerImported.
  4. "Structure of CrmE, a virus-encoded tumour necrosis factor receptor."
    Graham S.C., Bahar M.W., Abrescia N.G., Smith G.L., Stuart D.I., Grimes J.M.
    J. Mol. Biol. 372:660-671(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 22-153, ACTIVE SITE.
  5. "Genome Sequence of WAU86/88-1, a New Variant of Vaccinia Virus Lister Strain from Poland."
    Mavian C., Lopez-Bueno A., Alcami A.
    Genome Announc. 2:e01086-13(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WAU86/88-1Imported.

Entry informationi

Entry nameiQ8UYL3_9POXV
AccessioniPrimary (citable) accession number: Q8UYL3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.