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Protein

Mitogen-activated protein kinase

Gene

MAPK1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-111995 phospho-PLA2 pathway
R-GGA-112409 RAF-independent MAPK1/3 activation
R-GGA-112411 MAPK1 (ERK2) activation
R-GGA-1295596 Spry regulation of FGF signaling
R-GGA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-GGA-198753 ERK/MAPK targets
R-GGA-202670 ERKs are inactivated
R-GGA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-GGA-2559580 Oxidative Stress Induced Senescence
R-GGA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-GGA-2559585 Oncogene Induced Senescence
R-GGA-2871796 FCERI mediated MAPK activation
R-GGA-3371453 Regulation of HSF1-mediated heat shock response
R-GGA-375165 NCAM signaling for neurite out-growth
R-GGA-437239 Recycling pathway of L1
R-GGA-442742 CREB phosphorylation through the activation of Ras
R-GGA-444257 RSK activation
R-GGA-445144 Signal transduction by L1
R-GGA-450341 Activation of the AP-1 family of transcription factors
R-GGA-451533 ERK2 activation
R-GGA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-GGA-5654726 Negative regulation of FGFR1 signaling
R-GGA-5654727 Negative regulation of FGFR2 signaling
R-GGA-5654732 Negative regulation of FGFR3 signaling
R-GGA-5654733 Negative regulation of FGFR4 signaling
R-GGA-5663213 RHO GTPases Activate WASPs and WAVEs
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-5674499 Negative feedback regulation of MAPK pathway
R-GGA-5675221 Negative regulation of MAPK pathway
R-GGA-6798695 Neutrophil degranulation
R-GGA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-GGA-8939211 ESR-mediated signaling
R-GGA-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:MAPK1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000001501
ExpressionAtlasiQ8UWG6 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039208

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 321Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00910000144035
HOGENOMiHOG000233024
HOVERGENiHBG014652
KOiK04371
OrthoDBiEOG091G08QL

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008349 MAPK_ERK1/2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01770 ERK1ERK2MAPK
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UWG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAGAAAA GGSAGAGGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA
60 70 80 90 100
YDNVNKVRVA IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA
110 120 130 140 150
PTIEQMKDVY IVQDLMETDL YKLLKTQHLS NDHICYFLYQ ILRGLKYIHS
160 170 180 190 200
ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG FLTEYVATRW
210 220 230 240 250
YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG
260 270 280 290 300
ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DPKALDLLDK
310 320 330 340 350
MLTFNPHKRI EVEQALAHPY LEQYYDPSDE PVAEAPFKFD MELDDLPKEK
360
LKELIFEETA RFQPGYRS
Length:368
Mass (Da):41,942
Last modified:March 1, 2002 - v1
Checksum:iA6F3A3D27C6C9A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000193 Genomic DNA No translation available.
AY033635 mRNA Translation: AAK56503.1
RefSeqiNP_989481.1, NM_204150.1
XP_015130617.1, XM_015275131.1
UniGeneiGga.24275

Genome annotation databases

EnsembliENSGALT00000002280; ENSGALP00000002278; ENSGALG00000001501
GeneIDi373953
KEGGigga:373953

Similar proteinsi

Entry informationi

Entry nameiQ8UWG6_CHICK
AccessioniPrimary (citable) accession number: Q8UWG6
Secondary accession number(s): F1NRN9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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