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Protein

Mitogen-activated protein kinase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-111995. phospho-PLA2 pathway.
R-GGA-112409. RAF-independent MAPK1/3 activation.
R-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-198753. ERK/MAPK targets.
R-GGA-202670. ERKs are inactivated.
R-GGA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-GGA-2559580. Oxidative Stress Induced Senescence.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-2559585. Oncogene Induced Senescence.
R-GGA-2871796. FCERI mediated MAPK activation.
R-GGA-3371453. Regulation of HSF1-mediated heat shock response.
R-GGA-375165. NCAM signaling for neurite out-growth.
R-GGA-437239. Recycling pathway of L1.
R-GGA-442742. CREB phosphorylation through the activation of Ras.
R-GGA-444257. RSK activation.
R-GGA-445144. Signal transduction by L1.
R-GGA-450341. Activation of the AP-1 family of transcription factors.
R-GGA-451533. ERK2 activation.
R-GGA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-5674135. MAP2K and MAPK activation.
R-GGA-5674499. Negative feedback regulation of MAPK pathway.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.
R-GGA-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8UWG6.
PRIDEiQ8UWG6.

PTM databases

iPTMnetiQ8UWG6.

Expressioni

Gene expression databases

ExpressionAtlasiQ8UWG6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039208.

Structurei

3D structure databases

ProteinModelPortaliQ8UWG6.
SMRiQ8UWG6. Positions 23-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 321289Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04371.
PhylomeDBiQ8UWG6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UWG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAGAAAA GGSAGAGGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA
60 70 80 90 100
YDNVNKVRVA IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA
110 120 130 140 150
PTIEQMKDVY IVQDLMETDL YKLLKTQHLS NDHICYFLYQ ILRGLKYIHS
160 170 180 190 200
ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG FLTEYVATRW
210 220 230 240 250
YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG
260 270 280 290 300
ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DPKALDLLDK
310 320 330 340 350
MLTFNPHKRI EVEQALAHPY LEQYYDPSDE PVAEAPFKFD MELDDLPKEK
360
LKELIFEETA RFQPGYRS
Length:368
Mass (Da):41,942
Last modified:March 1, 2002 - v1
Checksum:iA6F3A3D27C6C9A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033635 mRNA. Translation: AAK56503.1.
RefSeqiNP_989481.1. NM_204150.1.
XP_015130617.1. XM_015275131.1.
UniGeneiGga.24275.

Genome annotation databases

GeneIDi373953.
KEGGigga:373953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033635 mRNA. Translation: AAK56503.1.
RefSeqiNP_989481.1. NM_204150.1.
XP_015130617.1. XM_015275131.1.
UniGeneiGga.24275.

3D structure databases

ProteinModelPortaliQ8UWG6.
SMRiQ8UWG6. Positions 23-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039208.

PTM databases

iPTMnetiQ8UWG6.

Proteomic databases

PaxDbiQ8UWG6.
PRIDEiQ8UWG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373953.
KEGGigga:373953.

Organism-specific databases

CTDi5594.

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04371.
PhylomeDBiQ8UWG6.

Enzyme and pathway databases

ReactomeiR-GGA-111995. phospho-PLA2 pathway.
R-GGA-112409. RAF-independent MAPK1/3 activation.
R-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-198753. ERK/MAPK targets.
R-GGA-202670. ERKs are inactivated.
R-GGA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-GGA-2559580. Oxidative Stress Induced Senescence.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-2559585. Oncogene Induced Senescence.
R-GGA-2871796. FCERI mediated MAPK activation.
R-GGA-3371453. Regulation of HSF1-mediated heat shock response.
R-GGA-375165. NCAM signaling for neurite out-growth.
R-GGA-437239. Recycling pathway of L1.
R-GGA-442742. CREB phosphorylation through the activation of Ras.
R-GGA-444257. RSK activation.
R-GGA-445144. Signal transduction by L1.
R-GGA-450341. Activation of the AP-1 family of transcription factors.
R-GGA-451533. ERK2 activation.
R-GGA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-5674135. MAP2K and MAPK activation.
R-GGA-5674499. Negative feedback regulation of MAPK pathway.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.
R-GGA-982772. Growth hormone receptor signaling.

Miscellaneous databases

NextBioi20813484.

Gene expression databases

ExpressionAtlasiQ8UWG6. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of ERK2 expressed in the chicken pineal gland."
    Kasahara T., Higashi C., Okano T., Fukada Y.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Pineal glandImported.

Entry informationi

Entry nameiQ8UWG6_CHICK
AccessioniPrimary (citable) accession number: Q8UWG6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.