Q8UWG6 (Q8UWG6_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Extracellular signal-regulated kinase 2 EMBL AAK56503.1
Organism	Gallus gallus (Chicken) EMBL AAK56503.1
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS003527
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS003527

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS003527 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS003527 Transferase
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Traceable author statement. Source: Reactome MyD88-dependent toll-like receptor signaling pathway Traceable author statement. Source: Reactome activation of MAPK activity involved in innate immune response Traceable author statement. Source: Reactome toll-like receptor 15 signaling pathway Traceable author statement. Source: Reactome toll-like receptor 2 signaling pathway Traceable author statement. Source: Reactome toll-like receptor 21 signaling pathway Traceable author statement. Source: Reactome toll-like receptor 3 signaling pathway Traceable author statement. Source: Reactome toll-like receptor 4 signaling pathway Traceable author statement. Source: Reactome toll-like receptor 5 signaling pathway Traceable author statement. Source: Reactome toll-like receptor 7 signaling pathway Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8UWG6 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: A6F3A3D27C6C9A44	FASTA	368	41,942
	10 20 30 40 50 60 MAAVAGAAAA GGSAGAGGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNVNKVRVA 70 80 90 100 110 120 IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL 130 140 150 160 170 180 YKLLKTQHLS NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR 190 200 210 220 230 240 VADPDHDHTG FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH 250 260 270 280 290 300 YLDQLNHILG ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DPKALDLLDK 310 320 330 340 350 360 MLTFNPHKRI EVEQALAHPY LEQYYDPSDE PVAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS

References

[1]	"Cloning of ERK2 expressed in the chicken pineal gland." Kasahara T., Higashi C., Okano T., Fukada Y. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pineal gland EMBL AAK56503.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY033635 mRNA. Translation: AAK56503.1.
IPI	IPI00589069.
RefSeq	NP_989481.1. NM_204150.1.
UniGene	Gga.24275.
3D structure databases
HSSP	HSSP built from PDB template 1PME based on UniProtKB P28482.
ProteinModelPortal	Q8UWG6.
SMR	Q8UWG6. Positions 23-366.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000039208. Q8UWG6.
Proteomic databases
PaxDb	Q8UWG6.
PRIDE	Q8UWG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	373953.
KEGG	gga:373953.
Organism-specific databases
CTD	5594.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233024.
HOVERGEN	HBG014652.
InParanoid	Q8UWG6.
KO	K04371.
OrthoDB	EOG45HRXM.
Enzyme and pathway databases
Reactome	REACT_147795. Innate Immune System.
Gene expression databases
ArrayExpress	Q8UWG6.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR003527. MAP_kinase_CS. IPR008349. MAPK_ERK1/2. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01770. ERK1ERK2MAPK.
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS01351. MAPK. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20813484.

Entry information

Entry name

Q8UWG6_CHICK

Accession

Primary (citable) accession number: Q8UWG6

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)