Q8UWA5 (CAH2_TRIHK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 2
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase II
Short name=CA-II

Gene names

Name:

ca2

Organism

Tribolodon hakonensis (Japanese dace)

Taxonomic identifier

151740 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Tribolodon

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 260	259	Carbonic anhydrase 2		PRO_0000077424
Regions
	Region	198 – 199	2	Substrate binding By similarity
Sites
	Active site	64	1	Proton acceptor By similarity
	Active site	127	1	By similarity
	Metal binding	94	1	Zinc; catalytic By similarity
	Metal binding	96	1	Zinc; catalytic By similarity
	Metal binding	119	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8UWA5 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: DA1D13C98307B88F	FASTA	260	29,133
	10 20 30 40 50 60 MSHGWGYADH NGPQKWCENF PIANGPRQSP IDIQTKGASY DDTLKPLKLK YDPTTSLDIL 70 80 90 100 110 120 NNGHSFQVTF ADDNDSSMLT EGPISGKYRL KQFHFHWGAS DGKGSEHTVD GKCYPAELHL 130 140 150 160 170 180 VHWNTKYASF GEAANKPDGL AVVGVFLQIG EDNPKLQKIL DAMDAIKSKG KQTSFTNFDP 190 200 210 220 230 240 TCLLPKSLEY WTYPGSLTTP PLYESVTWIV CKQPISVSSE QMKKFRSLLF TAEEEKACCM 250 260 VNNYRPPQPL KDRKVCASFK

References

[1]	"Mechanism of acid adaptation of a fish living in a pH 3.5 lake." Hirata T., Kaneko T., Ono T., Nakazato T., Furukawa N., Hasegawa S., Wakabayashi S., Shigekawa M., Chang M.H., Romero M.F., Hirose S. Am. J. Physiol. 284:R1199-R1212(2003) [PubMed: 12531781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB055617 mRNA. Translation: BAB83090.1.
3D structure databases
ProteinModelPortal	Q8UWA5.
SMR	Q8UWA5. Positions 2-260.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002837.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018440. Carbonic_anhydrase_CA2. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF28. Carbonic_anhydrase_CA2. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH2_TRIHK

Accession

Primary (citable) accession number: Q8UWA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program