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Protein
Submitted name:

Mu/m-calpain large subunit

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108PROSITE-ProRule annotation1
Active sitei265PROSITE-ProRule annotation1
Active sitei289PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi589 – 600PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi639 – 650PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

MEROPSiC02.003.

Names & Taxonomyi

Protein namesi
Submitted name:
Mu/m-calpain large subunitImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ8UW96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 347Calpain catalyticInterPro annotationAdd BLAST300
Domaini576 – 611EF-handInterPro annotationAdd BLAST36
Domaini626 – 661EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOVERGENiHBG012645.
KOiK01367.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029643. CAPN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF343. PTHR10183:SF343. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UW96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPFGGIASK LKIDRLKASG VGSHDCAVKY QNQDYESLKQ QCVESGILFE
60 70 80 90 100
DPNFPAIPSI LGFKELGPGS SKTRGVQWKR PSDIVDDPQF IIGGATRTDI
110 120 130 140 150
CQGALGDCWL LAAIGSLTLN EDLLHRVVPH GQSFQEDYAG IFHFQIWQFG
160 170 180 190 200
EWVDVVIDDL LPVKDGELVF VHSAECTEFW SALLEKAYAK LNGSYESLSG
210 220 230 240 250
GSTTEGFEDF TGGVAEMYEL RKAPRDLDKI IKRALERGSL LGCSIDITSA
260 270 280 290 300
FDMEAVTFKK LVKGHAYSVT ALKEVNYMGE MEKLIRIRNP WGQVEWTGAW
310 320 330 340 350
SDNSSEWNEV DPSEQEDLRL KMEDGEFWMS FQEFLRQFSR LEICNLTPDT
360 370 380 390 400
LNKEGLSKWH TTLYDGSWRR GSTAGGCRNN PATFWINPQF KVTLLEEDDD
410 420 430 440 450
PDDNELACSF LVALMQKNRR NERKAGQDMH TIGFAVYEVP DEFKGCQNVH
460 470 480 490 500
LKKDFFLRHQ SCARSETFIN LREVSTKIHL PPGEYIIVPS TFEPHKEADF
510 520 530 540 550
IMRIFTEKHS DIQELDEEVT ADLPEEEELT EDDVDDSFKA MFQQLAGDDM
560 570 580 590 600
EISVFELKTI LNRVVAKHKD LKTDGFGMEA CRQMVNLLDK DGSGKLGVVE
610 620 630 640 650
FQILWNKFEM AVMALLPACM GPVGINYTPS LQTVFREHDL DKSGTISSYE
660 670 680 690 700
LRIALESSGY KLNNKLIQVL VARYADSDMG IDFDNFVCCL VKLEAMFKFF
710 720
KALDEGDGTA EMNLGEWLTM TMSG
Length:724
Mass (Da):81,771
Last modified:March 1, 2002 - v1
Checksum:iCA5CB090AE7A4288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061521 mRNA. Translation: BAB83262.1.
RefSeqiNP_001082200.1. NM_001088731.1.
UniGeneiXl.73505.

Genome annotation databases

GeneIDi398288.
KEGGixla:398288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061521 mRNA. Translation: BAB83262.1.
RefSeqiNP_001082200.1. NM_001088731.1.
UniGeneiXl.73505.

3D structure databases

ProteinModelPortaliQ8UW96.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC02.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398288.
KEGGixla:398288.

Phylogenomic databases

HOVERGENiHBG012645.
KOiK01367.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029643. CAPN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF343. PTHR10183:SF343. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8UW96_XENLA
AccessioniPrimary (citable) accession number: Q8UW96
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: March 15, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.