ID   TBX20_CHICK             Reviewed;         440 AA.
AC   Q8UW76;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   24-JAN-2024, entry version 123.
DE   RecName: Full=T-box transcription factor TBX20;
DE            Short=T-box protein 20;
DE            Short=cTbx20;
GN   Name=TBX20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11862462; DOI=10.1007/s00427-001-0187-y;
RA   Iio A., Koide M., Hidaka K., Morisaki T.;
RT   "Expression pattern of novel chick T-box gene, Tbx20.";
RL   Dev. Genes Evol. 211:559-562(2001).
CC   -!- FUNCTION: Acts as a transcriptional regulator involved in heart
CC       developmental processes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DEVELOPMENTAL STAGE: Expression detected from stage 2 in the primitive
CC       streak. During subsequent stages of primitive streak formation (stages
CC       2-4), expression seen in the extraembryonic mesoderm and lateral
CC       mesoderm, and weakly in the elongating primitive streak. Concomitant
CC       with the onset of node and streak regression (stage 5), the expression
CC       in the lateral mesoderm extends to the anterior limit of the mesodermal
CC       cell layer. After gastrulation, continuously expressed in the heart-
CC       forming region and also detected in other regions such as the
CC       allantois, optic vesicle, hindbrain and ventral neural tube.
CC       {ECO:0000269|PubMed:11862462}.
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DR   EMBL; AB070554; BAB83622.1; -; mRNA.
DR   RefSeq; NP_989475.1; NM_204144.1.
DR   AlphaFoldDB; Q8UW76; -.
DR   SMR; Q8UW76; -.
DR   STRING; 9031.ENSGALP00000052363; -.
DR   PaxDb; 9031-ENSGALP00000019818; -.
DR   Ensembl; ENSGALT00000146306; ENSGALP00000078944; ENSGALG00000032097.
DR   Ensembl; ENSGALT00010046031.1; ENSGALP00010027428.1; ENSGALG00010019019.1.
DR   Ensembl; ENSGALT00015013137; ENSGALP00015006871; ENSGALG00015005594.
DR   GeneID; 373943; -.
DR   KEGG; gga:373943; -.
DR   CTD; 57057; -.
DR   VEuPathDB; HostDB:geneid_373943; -.
DR   eggNOG; KOG3586; Eukaryota.
DR   GeneTree; ENSGT00940000158741; -.
DR   HOGENOM; CLU_014430_7_1_1; -.
DR   InParanoid; Q8UW76; -.
DR   OMA; EDGHTTH; -.
DR   OrthoDB; 5323209at2759; -.
DR   PhylomeDB; Q8UW76; -.
DR   TreeFam; TF106341; -.
DR   PRO; PR:Q8UW76; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000032097; Expressed in heart.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
DR   GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
DR   GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR   GO; GO:0008015; P:blood circulation; IEA:Ensembl.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0003207; P:cardiac chamber formation; IEA:Ensembl.
DR   GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Ensembl.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0060973; P:cell migration involved in heart development; IMP:AgBase.
DR   GO; GO:2000793; P:cell proliferation involved in heart valve development; IDA:AgBase.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0036306; P:embryonic heart tube elongation; IEA:Ensembl.
DR   GO; GO:0003272; P:endocardial cushion formation; IEA:Ensembl.
DR   GO; GO:0035922; P:foramen ovale closure; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR   GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
DR   GO; GO:0097475; P:motor neuron migration; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:AgBase.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
DR   GO; GO:0003344; P:pericardium morphogenesis; IEA:Ensembl.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IMP:AgBase.
DR   GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   GO; GO:0003193; P:pulmonary valve formation; IEA:Ensembl.
DR   GO; GO:0060577; P:pulmonary vein morphogenesis; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0003175; P:tricuspid valve development; IEA:Ensembl.
DR   GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR   GO; GO:0021524; P:visceral motor neuron differentiation; IEA:Ensembl.
DR   CDD; cd20193; T-box_TBX20-like; 1.
DR   Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11267:SF190; T-BOX TRANSCRIPTION FACTOR TBX20; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..440
FT                   /note="T-box transcription factor TBX20"
FT                   /id="PRO_0000262692"
FT   DNA_BIND        103..282
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          308..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  48687 MW;  3F8AF3E327C0930C CRC64;
     MEYTPPPKPQ LSSRANAFSI AALMSSGSSK DKEAAESTIK PLEQFVEKSS CAQPLSDLSG
     LEPHGDFSGS PSALCTEPLI PTTPIIPSEE MAKISCSLET KELWDKFHEL GTEMIITKSG
     RRMFPTIRVS FSGVDPEAKY IVLMDIVPVD NKRYRYAYHR SSWLVAGKAD PPLPARLYVH
     PDSPFTGEQL MKQMVSFEKV KLTNNELDQH GHIILNSMHK YQPRVHIIKK KDHTASLLNL
     KSEEFRTFIF PETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLTDIE RESVESLIQK
     HSYARSPIRT YGGEDDLGDD SQATQSRGSA FTTSDNLSLS SWVSSSTSFP GFQHPQSLSA
     LGTSTASIAT PIPHPIQGSL PPYSRLGMPL TPSAIASSMQ GTGPTFPSFH MPRYHHYFQQ
     GPYAAIQGLR HSSAVMTPFV
//