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Q8UW76 (TBX20_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box transcription factor TBX20

Short name=T-box protein 20
Short name=cTbx20
Gene names
Name:TBX20
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a transcriptional regulator involved in heart developmental processes By similarity.

Subcellular location

Nucleus Potential.

Developmental stage

Expression detected from stage 2 in the primitive streak. During subsequent stages of primitive streak formation (stages 2-4), expression seen in the extraembryonic mesoderm and lateral mesoderm, and weakly in the elongating primitive streak. Concomitant with the onset of node and streak regression (stage 5), the expression in the lateral mesoderm extends to the anterior limit of the mesodermal cell layer. After gastrulation, continuously expressed in the heart-forming region and also detected in other regions such as the allantois, optic vesicle, hindbrain and ventral neural tube. Ref.1

Sequence similarities

Contains 1 T-box DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaortic valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

atrial septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

blood circulation

Inferred from electronic annotation. Source: Ensembl

cardiac chamber formation

Inferred from electronic annotation. Source: Ensembl

cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

cardiac right ventricle morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral pattern formation

Inferred from electronic annotation. Source: Ensembl

embryonic heart tube elongation

Inferred from electronic annotation. Source: Ensembl

endocardial cushion formation

Inferred from electronic annotation. Source: Ensembl

foramen ovale closure

Inferred from electronic annotation. Source: Ensembl

heart looping

Inferred from electronic annotation. Source: Ensembl

muscle contraction

Inferred from electronic annotation. Source: Ensembl

negative regulation of SMAD protein complex assembly

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

neuron migration

Inferred from electronic annotation. Source: Ensembl

outflow tract septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

pericardium morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

pulmonary valve formation

Inferred from electronic annotation. Source: Ensembl

pulmonary vein morphogenesis

Inferred from electronic annotation. Source: Ensembl

tricuspid valve development

Inferred from electronic annotation. Source: Ensembl

visceral motor neuron differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA polymerase II regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440T-box transcription factor TBX20
PRO_0000262692

Regions

DNA binding103 – 282180T-box

Sequences

Sequence LengthMass (Da)Tools
Q8UW76 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 3F8AF3E327C0930C

FASTA44048,687
        10         20         30         40         50         60 
MEYTPPPKPQ LSSRANAFSI AALMSSGSSK DKEAAESTIK PLEQFVEKSS CAQPLSDLSG 

        70         80         90        100        110        120 
LEPHGDFSGS PSALCTEPLI PTTPIIPSEE MAKISCSLET KELWDKFHEL GTEMIITKSG 

       130        140        150        160        170        180 
RRMFPTIRVS FSGVDPEAKY IVLMDIVPVD NKRYRYAYHR SSWLVAGKAD PPLPARLYVH 

       190        200        210        220        230        240 
PDSPFTGEQL MKQMVSFEKV KLTNNELDQH GHIILNSMHK YQPRVHIIKK KDHTASLLNL 

       250        260        270        280        290        300 
KSEEFRTFIF PETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLTDIE RESVESLIQK 

       310        320        330        340        350        360 
HSYARSPIRT YGGEDDLGDD SQATQSRGSA FTTSDNLSLS SWVSSSTSFP GFQHPQSLSA 

       370        380        390        400        410        420 
LGTSTASIAT PIPHPIQGSL PPYSRLGMPL TPSAIASSMQ GTGPTFPSFH MPRYHHYFQQ 

       430        440 
GPYAAIQGLR HSSAVMTPFV 

« Hide

References

[1]"Expression pattern of novel chick T-box gene, Tbx20."
Iio A., Koide M., Hidaka K., Morisaki T.
Dev. Genes Evol. 211:559-562(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB070554 mRNA. Translation: BAB83622.1.
RefSeqNP_989475.1. NM_204144.1.
UniGeneGga.4201.

3D structure databases

ProteinModelPortalQ8UW76.
SMRQ8UW76. Positions 98-282.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000019818.

Proteomic databases

PaxDbQ8UW76.
PRIDEQ8UW76.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000019845; ENSGALP00000019818; ENSGALG00000012151.
GeneID373943.
KEGGgga:373943.

Organism-specific databases

CTD57057.

Phylogenomic databases

eggNOGNOG272513.
GeneTreeENSGT00740000115189.
HOGENOMHOG000286000.
HOVERGENHBG067710.
InParanoidQ8UW76.
KOK10185.
OMARHSSTVM.
OrthoDBEOG7GN2PM.
PhylomeDBQ8UW76.
TreeFamTF106341.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813475.
PROQ8UW76.

Entry information

Entry nameTBX20_CHICK
AccessionPrimary (citable) accession number: Q8UW76
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families