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Protein

T-box transcription factor TBX20

Gene

TBX20

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator involved in heart developmental processes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi103 – 282180T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II transcription coactivator activity Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. aortic valve morphogenesis Source: Ensembl
  2. atrial septum morphogenesis Source: Ensembl
  3. blood circulation Source: Ensembl
  4. cardiac chamber formation Source: Ensembl
  5. cardiac muscle tissue morphogenesis Source: Ensembl
  6. cardiac right ventricle morphogenesis Source: Ensembl
  7. cell proliferation Source: Ensembl
  8. dorsal/ventral pattern formation Source: Ensembl
  9. embryonic heart tube elongation Source: Ensembl
  10. endocardial cushion formation Source: Ensembl
  11. foramen ovale closure Source: Ensembl
  12. heart looping Source: Ensembl
  13. muscle contraction Source: Ensembl
  14. negative regulation of SMAD protein complex assembly Source: Ensembl
  15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. neuron migration Source: Ensembl
  17. outflow tract septum morphogenesis Source: Ensembl
  18. patterning of blood vessels Source: Ensembl
  19. pericardium morphogenesis Source: Ensembl
  20. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  21. pulmonary valve formation Source: Ensembl
  22. pulmonary vein morphogenesis Source: Ensembl
  23. tricuspid valve development Source: Ensembl
  24. visceral motor neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX20
Short name:
T-box protein 20
Short name:
cTbx20
Gene namesi
Name:TBX20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440T-box transcription factor TBX20PRO_0000262692Add
BLAST

Proteomic databases

PaxDbiQ8UW76.
PRIDEiQ8UW76.

Expressioni

Developmental stagei

Expression detected from stage 2 in the primitive streak. During subsequent stages of primitive streak formation (stages 2-4), expression seen in the extraembryonic mesoderm and lateral mesoderm, and weakly in the elongating primitive streak. Concomitant with the onset of node and streak regression (stage 5), the expression in the lateral mesoderm extends to the anterior limit of the mesodermal cell layer. After gastrulation, continuously expressed in the heart-forming region and also detected in other regions such as the allantois, optic vesicle, hindbrain and ventral neural tube.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019818.

Structurei

3D structure databases

ProteinModelPortaliQ8UW76.
SMRiQ8UW76. Positions 98-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG272513.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286000.
HOVERGENiHBG067710.
InParanoidiQ8UW76.
KOiK10185.
OMAiTVMTPFV.
OrthoDBiEOG7GN2PM.
PhylomeDBiQ8UW76.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UW76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYTPPPKPQ LSSRANAFSI AALMSSGSSK DKEAAESTIK PLEQFVEKSS
60 70 80 90 100
CAQPLSDLSG LEPHGDFSGS PSALCTEPLI PTTPIIPSEE MAKISCSLET
110 120 130 140 150
KELWDKFHEL GTEMIITKSG RRMFPTIRVS FSGVDPEAKY IVLMDIVPVD
160 170 180 190 200
NKRYRYAYHR SSWLVAGKAD PPLPARLYVH PDSPFTGEQL MKQMVSFEKV
210 220 230 240 250
KLTNNELDQH GHIILNSMHK YQPRVHIIKK KDHTASLLNL KSEEFRTFIF
260 270 280 290 300
PETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLTDIE RESVESLIQK
310 320 330 340 350
HSYARSPIRT YGGEDDLGDD SQATQSRGSA FTTSDNLSLS SWVSSSTSFP
360 370 380 390 400
GFQHPQSLSA LGTSTASIAT PIPHPIQGSL PPYSRLGMPL TPSAIASSMQ
410 420 430 440
GTGPTFPSFH MPRYHHYFQQ GPYAAIQGLR HSSAVMTPFV
Length:440
Mass (Da):48,687
Last modified:March 1, 2002 - v1
Checksum:i3F8AF3E327C0930C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070554 mRNA. Translation: BAB83622.1.
RefSeqiNP_989475.1. NM_204144.1.
UniGeneiGga.4201.

Genome annotation databases

EnsembliENSGALT00000019845; ENSGALP00000019818; ENSGALG00000012151.
GeneIDi373943.
KEGGigga:373943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070554 mRNA. Translation: BAB83622.1.
RefSeqiNP_989475.1. NM_204144.1.
UniGeneiGga.4201.

3D structure databases

ProteinModelPortaliQ8UW76.
SMRiQ8UW76. Positions 98-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019818.

Proteomic databases

PaxDbiQ8UW76.
PRIDEiQ8UW76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019845; ENSGALP00000019818; ENSGALG00000012151.
GeneIDi373943.
KEGGigga:373943.

Organism-specific databases

CTDi57057.

Phylogenomic databases

eggNOGiNOG272513.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286000.
HOVERGENiHBG067710.
InParanoidiQ8UW76.
KOiK10185.
OMAiTVMTPFV.
OrthoDBiEOG7GN2PM.
PhylomeDBiQ8UW76.
TreeFamiTF106341.

Miscellaneous databases

NextBioi20813475.
PROiQ8UW76.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression pattern of novel chick T-box gene, Tbx20."
    Iio A., Koide M., Hidaka K., Morisaki T.
    Dev. Genes Evol. 211:559-562(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTBX20_CHICK
AccessioniPrimary (citable) accession number: Q8UW76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: February 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.