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Q8UW76

- TBX20_CHICK

UniProt

Q8UW76 - TBX20_CHICK

Protein

T-box transcription factor TBX20

Gene

TBX20

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional regulator involved in heart developmental processes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi103 – 282180T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    2. RNA polymerase II transcription coactivator activity Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. aortic valve morphogenesis Source: Ensembl
    2. atrial septum morphogenesis Source: Ensembl
    3. blood circulation Source: Ensembl
    4. cardiac chamber formation Source: Ensembl
    5. cardiac muscle tissue morphogenesis Source: Ensembl
    6. cardiac right ventricle morphogenesis Source: Ensembl
    7. cell proliferation Source: Ensembl
    8. dorsal/ventral pattern formation Source: Ensembl
    9. embryonic heart tube elongation Source: Ensembl
    10. endocardial cushion formation Source: Ensembl
    11. foramen ovale closure Source: Ensembl
    12. heart looping Source: Ensembl
    13. muscle contraction Source: Ensembl
    14. negative regulation of SMAD protein complex assembly Source: Ensembl
    15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. neuron migration Source: Ensembl
    17. outflow tract septum morphogenesis Source: Ensembl
    18. patterning of blood vessels Source: Ensembl
    19. pericardium morphogenesis Source: Ensembl
    20. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    21. pulmonary valve formation Source: Ensembl
    22. pulmonary vein morphogenesis Source: Ensembl
    23. tricuspid valve development Source: Ensembl
    24. visceral motor neuron differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX20
    Short name:
    T-box protein 20
    Short name:
    cTbx20
    Gene namesi
    Name:TBX20
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440T-box transcription factor TBX20PRO_0000262692Add
    BLAST

    Proteomic databases

    PaxDbiQ8UW76.
    PRIDEiQ8UW76.

    Expressioni

    Developmental stagei

    Expression detected from stage 2 in the primitive streak. During subsequent stages of primitive streak formation (stages 2-4), expression seen in the extraembryonic mesoderm and lateral mesoderm, and weakly in the elongating primitive streak. Concomitant with the onset of node and streak regression (stage 5), the expression in the lateral mesoderm extends to the anterior limit of the mesodermal cell layer. After gastrulation, continuously expressed in the heart-forming region and also detected in other regions such as the allantois, optic vesicle, hindbrain and ventral neural tube.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000019818.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8UW76.
    SMRiQ8UW76. Positions 98-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG272513.
    GeneTreeiENSGT00740000115189.
    HOGENOMiHOG000286000.
    HOVERGENiHBG067710.
    InParanoidiQ8UW76.
    KOiK10185.
    OMAiRHSSTVM.
    OrthoDBiEOG7GN2PM.
    PhylomeDBiQ8UW76.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8UW76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYTPPPKPQ LSSRANAFSI AALMSSGSSK DKEAAESTIK PLEQFVEKSS    50
    CAQPLSDLSG LEPHGDFSGS PSALCTEPLI PTTPIIPSEE MAKISCSLET 100
    KELWDKFHEL GTEMIITKSG RRMFPTIRVS FSGVDPEAKY IVLMDIVPVD 150
    NKRYRYAYHR SSWLVAGKAD PPLPARLYVH PDSPFTGEQL MKQMVSFEKV 200
    KLTNNELDQH GHIILNSMHK YQPRVHIIKK KDHTASLLNL KSEEFRTFIF 250
    PETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLTDIE RESVESLIQK 300
    HSYARSPIRT YGGEDDLGDD SQATQSRGSA FTTSDNLSLS SWVSSSTSFP 350
    GFQHPQSLSA LGTSTASIAT PIPHPIQGSL PPYSRLGMPL TPSAIASSMQ 400
    GTGPTFPSFH MPRYHHYFQQ GPYAAIQGLR HSSAVMTPFV 440
    Length:440
    Mass (Da):48,687
    Last modified:March 1, 2002 - v1
    Checksum:i3F8AF3E327C0930C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070554 mRNA. Translation: BAB83622.1.
    RefSeqiNP_989475.1. NM_204144.1.
    UniGeneiGga.4201.

    Genome annotation databases

    EnsembliENSGALT00000019845; ENSGALP00000019818; ENSGALG00000012151.
    GeneIDi373943.
    KEGGigga:373943.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070554 mRNA. Translation: BAB83622.1 .
    RefSeqi NP_989475.1. NM_204144.1.
    UniGenei Gga.4201.

    3D structure databases

    ProteinModelPortali Q8UW76.
    SMRi Q8UW76. Positions 98-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000019818.

    Proteomic databases

    PaxDbi Q8UW76.
    PRIDEi Q8UW76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000019845 ; ENSGALP00000019818 ; ENSGALG00000012151 .
    GeneIDi 373943.
    KEGGi gga:373943.

    Organism-specific databases

    CTDi 57057.

    Phylogenomic databases

    eggNOGi NOG272513.
    GeneTreei ENSGT00740000115189.
    HOGENOMi HOG000286000.
    HOVERGENi HBG067710.
    InParanoidi Q8UW76.
    KOi K10185.
    OMAi RHSSTVM.
    OrthoDBi EOG7GN2PM.
    PhylomeDBi Q8UW76.
    TreeFami TF106341.

    Miscellaneous databases

    NextBioi 20813475.
    PROi Q8UW76.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of novel chick T-box gene, Tbx20."
      Iio A., Koide M., Hidaka K., Morisaki T.
      Dev. Genes Evol. 211:559-562(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTBX20_CHICK
    AccessioniPrimary (citable) accession number: Q8UW76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3