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Q8UW64 (PSB9_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-9

EC=3.4.25.1
Alternative name(s):
Low molecular mass protein 2
Gene names
Name:psmb9
Synonyms:lmp2
OrganismOryzias latipes (Medaka fish) (Japanese ricefish) [Reference proteome]
Taxonomic identifier8090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Post-translational modification

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 1818Removed in mature form By similarity
PRO_0000026633
Chain19 – 217199Proteasome subunit beta type-9
PRO_0000026634

Sites

Active site191Nucleophile By similarity
Site18 – 192Cleavage; by autocatalysis By similarity

Natural variations

Natural variant51Missing in strain: HD-RR.

Sequences

Sequence LengthMass (Da)Tools
Q8UW64 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A9AB1C04E57EB4C9

FASTA21723,547
        10         20         30         40         50         60 
MLGEEAEPQW ISEEVKTGTT IIAIEFNGGV VLGSDSRVSA GDSVVNRVMN KLSPLHDKIY 

        70         80         90        100        110        120 
CALSGSAADA QTIAEMVNYQ LDVHSLEIDE DPQVRSAATL VKNISYKYKE ELSAHLIVAG 

       130        140        150        160        170        180 
WDRRDGGQVF ATLGGLLTRQ PFAIGGSGSS YVYGFVDAEY RRGMTKEECQ KFVVNTLALA 

       190        200        210 
MNRDGSSGGV AYIVTIDEHS TDEKVILGND LPTFFDQ 

« Hide

References

[1]"Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes)."
Matsuo M.Y., Asakawa S., Shimizu N., Kimura H., Nonaka M.
Immunogenetics 53:930-940(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Hd-rR and HNI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000027 Genomic DNA. Translation: BAB83845.1.
AB073378 Genomic DNA. Translation: BAB84548.1.
RefSeqNP_001265756.1. NM_001278827.1.
UniGeneOla.82.

3D structure databases

ProteinModelPortalQ8UW64.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100049434.
KEGGola:100049434.

Organism-specific databases

CTD5698.

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000091079.
HOVERGENHBG000123.
InParanoidQ8UW64.
KOK02741.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB9_ORYLA
AccessionPrimary (citable) accession number: Q8UW64
Secondary accession number(s): Q8UWC6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries