Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8UW64

- PSB9_ORYLA

UniProt

Q8UW64 - PSB9_ORYLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proteasome subunit beta type-9

Gene

psmb9

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides By similarity.By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 192Cleavage; by autocatalysisBy similarity
Active sitei19 – 191NucleophileBy similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
  2. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Keywords - Biological processi

Immunity

Protein family/group databases

MEROPSiT01.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-9 (EC:3.4.25.1)
Alternative name(s):
Low molecular mass protein 2
Gene namesi
Name:psmb9
Synonyms:lmp2
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Unplaced

Subcellular locationi

Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1818Removed in mature formBy similarityPRO_0000026633Add
BLAST
Chaini19 – 217199Proteasome subunit beta type-9PRO_0000026634Add
BLAST

Post-translational modificationi

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity By similarity.By similarity

Keywords - PTMi

Zymogen

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8UW64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091079.
HOVERGENiHBG000123.
InParanoidiQ8UW64.
KOiK02741.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8UW64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGEEAEPQW ISEEVKTGTT IIAIEFNGGV VLGSDSRVSA GDSVVNRVMN
60 70 80 90 100
KLSPLHDKIY CALSGSAADA QTIAEMVNYQ LDVHSLEIDE DPQVRSAATL
110 120 130 140 150
VKNISYKYKE ELSAHLIVAG WDRRDGGQVF ATLGGLLTRQ PFAIGGSGSS
160 170 180 190 200
YVYGFVDAEY RRGMTKEECQ KFVVNTLALA MNRDGSSGGV AYIVTIDEHS
210
TDEKVILGND LPTFFDQ
Length:217
Mass (Da):23,547
Last modified:March 1, 2002 - v1
Checksum:iA9AB1C04E57EB4C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51Missing in strain: HD-RR.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000027 Genomic DNA. Translation: BAB83845.1.
AB073378 Genomic DNA. Translation: BAB84548.1.
RefSeqiNP_001265756.1. NM_001278827.1.
UniGeneiOla.82.

Genome annotation databases

GeneIDi100049434.
KEGGiola:100049434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000027 Genomic DNA. Translation: BAB83845.1 .
AB073378 Genomic DNA. Translation: BAB84548.1 .
RefSeqi NP_001265756.1. NM_001278827.1.
UniGenei Ola.82.

3D structure databases

ProteinModelPortali Q8UW64.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100049434.
KEGGi ola:100049434.

Organism-specific databases

CTDi 5698.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091079.
HOVERGENi HBG000123.
InParanoidi Q8UW64.
KOi K02741.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes)."
    Matsuo M.Y., Asakawa S., Shimizu N., Kimura H., Nonaka M.
    Immunogenetics 53:930-940(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hd-rR and HNI.

Entry informationi

Entry nameiPSB9_ORYLA
AccessioniPrimary (citable) accession number: Q8UW64
Secondary accession number(s): Q8UWC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3