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Protein

Dual specificity protein phosphatase

Gene

DUSP6

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei293 – 2931Phosphocysteine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation, EC:3.1.3.48UniRule annotation)
Gene namesi
Name:DUSP6Imported
Synonyms:dusp6Imported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000043763.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 149119RhodaneseInterPro annotationAdd
BLAST
Domaini206 – 348143Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini262 – 33069TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1717. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000294079.
KOiK04459.
OMAiPETEYEC.
OrthoDBiEOG793B7W.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UW48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDKLKPVVQ LDTIMAISKT VGWLREQLET RRDGLLVMDC RAQELYKSSH
60 70 80 90 100
VETAINVAIP SLMLRRLKKG NLPVRSLLSD GEDREKFVRR CKTDTIVLYD
110 120 130 140 150
EYSREWNENV DGGSVLGLLL RRMKDEGYKA YYLEGGFSKF QAEFPGLCET
160 170 180 190 200
NLDGSSNSSS PTAQVLGLGG LRISSDSSDI ESDIDRDPCS ATDSDGSPLS
210 220 230 240 250
NPQPSFPVEI LPHLYLGCAK DATNLDVLEE YGIKYILNVT PNLPNLFENA
260 270 280 290 300
GEFKYKQIPI SDHWSQNLSQ FFPEAIGFID EARGQKCGVL VHCLAGISRS
310 320 330 340 350
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLSLK
360 370 380
SPCDNRISAP SQPLYFTTPT NHNVFQLDPL EST
Length:383
Mass (Da):42,832
Last modified:March 1, 2002 - v1
Checksum:i0804F64E9C8E49B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090119 Genomic DNA. Translation: AAL40358.1.
RefSeqiNP_001163824.1. NM_001170353.1.
UniGeneiTru.4129.

Genome annotation databases

EnsembliENSTRUT00000043909; ENSTRUP00000043763; ENSTRUG00000017083.
GeneIDi100137150.
KEGGitru:100137150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090119 Genomic DNA. Translation: AAL40358.1.
RefSeqiNP_001163824.1. NM_001170353.1.
UniGeneiTru.4129.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000043763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTRUT00000043909; ENSTRUP00000043763; ENSTRUG00000017083.
GeneIDi100137150.
KEGGitru:100137150.

Organism-specific databases

CTDi1848.

Phylogenomic databases

eggNOGiKOG1717. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000294079.
KOiK04459.
OMAiPETEYEC.
OrthoDBiEOG793B7W.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hd-rRImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8UW48_TAKRU
AccessioniPrimary (citable) accession number: Q8UW48
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.