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Protein

Dual specificity protein phosphatase

Gene

DUSP6

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei293Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation, EC:3.1.3.48UniRule annotation)
Gene namesi
Name:DUSP6Imported
Synonyms:dusp6Imported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000043763

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 149RhodaneseInterPro annotationAdd BLAST119
Domaini206 – 348Tyrosine-protein phosphataseInterPro annotationAdd BLAST143
Domaini262 – 330TYR_PHOSPHATASE_2InterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1717 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294079
KOiK21946
OMAiLLVMDCR
OrthoDBiEOG091G0249
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UW48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDKLKPVVQ LDTIMAISKT VGWLREQLET RRDGLLVMDC RAQELYKSSH
60 70 80 90 100
VETAINVAIP SLMLRRLKKG NLPVRSLLSD GEDREKFVRR CKTDTIVLYD
110 120 130 140 150
EYSREWNENV DGGSVLGLLL RRMKDEGYKA YYLEGGFSKF QAEFPGLCET
160 170 180 190 200
NLDGSSNSSS PTAQVLGLGG LRISSDSSDI ESDIDRDPCS ATDSDGSPLS
210 220 230 240 250
NPQPSFPVEI LPHLYLGCAK DATNLDVLEE YGIKYILNVT PNLPNLFENA
260 270 280 290 300
GEFKYKQIPI SDHWSQNLSQ FFPEAIGFID EARGQKCGVL VHCLAGISRS
310 320 330 340 350
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLSLK
360 370 380
SPCDNRISAP SQPLYFTTPT NHNVFQLDPL EST
Length:383
Mass (Da):42,832
Last modified:March 1, 2002 - v1
Checksum:i0804F64E9C8E49B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090119 Genomic DNA Translation: AAL40358.1
RefSeqiNP_001163824.1, NM_001170353.1
UniGeneiTru.4129

Genome annotation databases

EnsembliENSTRUT00000043909; ENSTRUP00000043763; ENSTRUG00000017083
GeneIDi100137150
KEGGitru:100137150

Similar proteinsi

Entry informationi

Entry nameiQ8UW48_TAKRU
AccessioniPrimary (citable) accession number: Q8UW48
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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