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Protein

Cytochrome P450

Gene

cyp1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular aromatic compound metabolic process Source: ZFIN
  • cellular response to organic cyclic compound Source: ZFIN
  • cellular response to xenobiotic stimulus Source: ZFIN
  • response to xenobiotic stimulus Source: ZFIN

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-156581 Methylation
R-DRE-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
R-DRE-211981 Xenobiotics
R-DRE-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-DRE-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-DRE-5423646 Aflatoxin activation and detoxification
R-DRE-9018681 Biosynthesis of protectins
R-DRE-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:cyp1aImported
Synonyms:CYP1AImported, cyp1A1Imported, cyp1a1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-011219-1 cyp1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, MicrosomeUniRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000098315

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033498

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOVERGENiHBG106944
KOiK07408
OMAiNNWQDYI
OrthoDBiEOG091G0BT8
TreeFamiTF105095

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008066 Cyt_P450_E_grp-I_CYP1
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01683 EP450ICYP1A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UW07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTILPILG PISVSESLVA IITICLVYLL MRLNRTKIPD GLQKLPGPKP
60 70 80 90 100
LPIIGNVLEI GNNPHLSLTA MSKCYGPVFQ IQIGMRPVVV LSGNDVIRQA
110 120 130 140 150
LLKQGEEFSG RPELYSTKFI SDGKSLAFST DQVGVWRARR KLALNALRTF
160 170 180 190 200
STVQGKSPKY SCALEEHISN EGLYLVQRLH SVMKADGSFD PFRHIVVSVA
210 220 230 240 250
NVICGICFGR RHSHDDDELV RLVNMSDEFG KIVGSGNPAD FIPFLRILPS
260 270 280 290 300
TTMKKFLDIN ERFSKFMKRL VMEHYDTFDK DNIRDITDSL INHCEDRKLD
310 320 330 340 350
ENSNLQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVH YPEVQERLQR
360 370 380 390 400
ELDEKIGKDR TPLLSDRANL PLLESFILEI FRHSSFLPFT IPHCTSKDTS
410 420 430 440 450
LNGYFIPKDT CVFVNQWQVN HDPELWKDPS SFIPDRFLTA DGTELNKLEG
460 470 480 490 500
EKVLVFGLGK RRCIGESIGR AEVFLFLAIL LQRLKFTGMP GEMLDMTPEY
510
GLTMKHKRCL LRVTPQPGF
Length:519
Mass (Da):58,560
Last modified:March 1, 2004 - v2
Checksum:i3CFC55337906E7C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU462829 Genomic DNA No translation available.
AF210727 mRNA Translation: AAL54873.2
AB078927 mRNA Translation: BAB90841.1
RefSeqiNP_571954.1, NM_131879.2
UniGeneiDr.105078

Genome annotation databases

EnsembliENSDART00000161538; ENSDARP00000139599; ENSDARG00000098315
GeneIDi140634
KEGGidre:140634

Similar proteinsi

Entry informationi

Entry nameiQ8UW07_DANRE
AccessioniPrimary (citable) accession number: Q8UW07
Secondary accession number(s): Q8QGS5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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