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Protein

Cytochrome P450

Gene

cyp1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular aromatic compound metabolic process Source: ZFIN
  • cellular response to organic cyclic compound Source: ZFIN
  • cellular response to xenobiotic stimulus Source: ZFIN
  • response to xenobiotic stimulus Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-156581. Methylation.
R-DRE-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-DRE-211981. Xenobiotics.
R-DRE-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-DRE-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-DRE-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:cyp1aImported
Synonyms:CYP1AImported, cyp1A1Imported, cyp1a1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-011219-1. cyp1a.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, MicrosomeUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033498.

Structurei

3D structure databases

SMRiQ8UW07. Positions 38-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOVERGENiHBG106944.
KOiK07408.
OMAiINERFSK.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ8UW07.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UW07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTILPILG PISVSESLVA IITICLVYLL MRLNRTKIPD GLQKLPGPKP
60 70 80 90 100
LPIIGNVLEI GNNPHLSLTA MSKCYGPVFQ IQIGMRPVVV LSGNDVIRQA
110 120 130 140 150
LLKQGEEFSG RPELYSTKFI SDGKSLAFST DQVGVWRARR KLALNALRTF
160 170 180 190 200
STVQGKSPKY SCALEEHISN EGLYLVQRLH SVMKADGSFD PFRHIVVSVA
210 220 230 240 250
NVICGICFGR RHSHDDDELV RLVNMSDEFG KIVGSGNPAD FIPFLRILPS
260 270 280 290 300
TTMKKFLDIN ERFSKFMKRL VMEHYDTFDK DNIRDITDSL INHCEDRKLD
310 320 330 340 350
ENSNLQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVH YPEVQERLQR
360 370 380 390 400
ELDEKIGKDR TPLLSDRANL PLLESFILEI FRHSSFLPFT IPHCTSKDTS
410 420 430 440 450
LNGYFIPKDT CVFVNQWQVN HDPELWKDPS SFIPDRFLTA DGTELNKLEG
460 470 480 490 500
EKVLVFGLGK RRCIGESIGR AEVFLFLAIL LQRLKFTGMP GEMLDMTPEY
510
GLTMKHKRCL LRVTPQPGF
Length:519
Mass (Da):58,560
Last modified:March 1, 2004 - v2
Checksum:i3CFC55337906E7C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU462829 Genomic DNA. No translation available.
AF210727 mRNA. Translation: AAL54873.2.
AB078927 mRNA. Translation: BAB90841.1.
RefSeqiNP_571954.1. NM_131879.1.
UniGeneiDr.105078.

Genome annotation databases

EnsembliENSDART00000161538; ENSDARP00000139599; ENSDARG00000098315.
GeneIDi140634.
KEGGidre:140634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU462829 Genomic DNA. No translation available.
AF210727 mRNA. Translation: AAL54873.2.
AB078927 mRNA. Translation: BAB90841.1.
RefSeqiNP_571954.1. NM_131879.1.
UniGeneiDr.105078.

3D structure databases

SMRiQ8UW07. Positions 38-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033498.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000161538; ENSDARP00000139599; ENSDARG00000098315.
GeneIDi140634.
KEGGidre:140634.

Organism-specific databases

CTDi140634.
ZFINiZDB-GENE-011219-1. cyp1a.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOVERGENiHBG106944.
KOiK07408.
OMAiINERFSK.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ8UW07.
TreeFamiTF105095.

Enzyme and pathway databases

ReactomeiR-DRE-156581. Methylation.
R-DRE-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-DRE-211981. Xenobiotics.
R-DRE-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-DRE-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-DRE-5423646. Aflatoxin activation and detoxification.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yang Y.-H., Buhler D.R.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos."
    Yamazaki K., Teraoka H., Dong W., Stegeman J.J., Hiraga T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Buhler D.R.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Phenylthiourea as a weak activator of aryl hydrocarbon receptor inhibiting 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 transcription in zebrafish embryo."
    Wang W.D., Wang Y., Wen H.J., Buhler D.R., Hu C.H.
    Biochem. Pharmacol. 68:63-71(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  6. Ensembl
    Submitted (NOV-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ8UW07_DANRE
AccessioniPrimary (citable) accession number: Q8UW07
Secondary accession number(s): Q8QGS5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2004
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.