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Q8UVX8 (IOD2_NEOFS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type II iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene names
Name:dio2
OrganismNeoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Taxonomic identifier7892 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiDipnoiCeratodontiformesCeratodontidaeNeoceratodus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) By similarity.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentMembrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

thyroid hormone metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Type II iodothyronine deiodinase
PRO_0000318643

Regions

Transmembrane8 – 2821Helical; Potential

Sites

Active site1281

Amino acid modifications

Non-standard residue1281Selenocysteine
Non-standard residue2611Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q8UVX8 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: 66F17725DF72E62B

FASTA26930,513
        10         20         30         40         50         60 
MGLLSVDLLI TLQILPWFFS NCLFLALYDS VVLLKHVILL LSCSKSSRGE WRRMLTSEGL 

        70         80         90        100        110        120 
RTVWNSFLLD AYKQVKLGGD APNSKVVRVT SGCCRRRSFS GKGESECHLL DFASSNRPLV 

       130        140        150        160        170        180 
VNFGSATUPP FISQLPTFRK LVEEFSDVAD FLLVYIDEAH PADGWAAPGV ATKSFEVKKH 

       190        200        210        220        230        240 
RSQEERCVAA HKLLEHFSLP PQCQVVADCM DNNTNVAYGV SFERVCIVQR QKIAYLGGKG 

       250        260 
PFFYNLKEVR HWLEQTYRKR UVPTCELIM 

« Hide

References

[1]"Deiodinase type II and tissue specific mRNA alternative splicing in the Australian lungfish, Neoceratodus forsteri."
Sutija M., Longhurst T.J., Joss J.M.
Gen. Comp. Endocrinol. 132:409-417(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF327438 mRNA. Translation: AAL56981.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000099.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD2_NEOFS
AccessionPrimary (citable) accession number: Q8UVX8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families