Q8UVX8 (IOD2_NEOFS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type II iodothyronine deiodinase
EC=1.97.1.10

Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase

Gene names

Name:

dio2

Organism

Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)

Taxonomic identifier

7892 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnoi › Ceratodontimorpha › Ceratodontiformes › Ceratodontidae › Neoceratodus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) By similarity.
Catalytic activity	3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
Biological process	Thyroid hormones biosynthesis
Cellular component	Membrane
Coding sequence diversity	Selenocysteine
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	hormone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW thyroid hormone metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	thyroxine 5'-deiodinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Type II iodothyronine deiodinase		PRO_0000318643
Regions
	Transmembrane	8 – 28	21	Helical; Potential
Sites
	Active site	128	1
Amino acid modifications
	Non-standard residue	128	1	Selenocysteine
	Non-standard residue	261	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q8UVX8 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: 66F17725DF72E62B	FASTA	269	30,513
	10 20 30 40 50 60 MGLLSVDLLI TLQILPWFFS NCLFLALYDS VVLLKHVILL LSCSKSSRGE WRRMLTSEGL 70 80 90 100 110 120 RTVWNSFLLD AYKQVKLGGD APNSKVVRVT SGCCRRRSFS GKGESECHLL DFASSNRPLV 130 140 150 160 170 180 VNFGSATUPP FISQLPTFRK LVEEFSDVAD FLLVYIDEAH PADGWAAPGV ATKSFEVKKH 190 200 210 220 230 240 RSQEERCVAA HKLLEHFSLP PQCQVVADCM DNNTNVAYGV SFERVCIVQR QKIAYLGGKG 250 260 PFFYNLKEVR HWLEQTYRKR UVPTCELIM

References

[1]	"Deiodinase type II and tissue specific mRNA alternative splicing in the Australian lungfish, Neoceratodus forsteri." Sutija M., Longhurst T.J., Joss J.M. Gen. Comp. Endocrinol. 132:409-417(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF327438 mRNA. Translation: AAL56981.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000099.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR000643. Iodothyronine_deiodinase. IPR008261. Iodothyronine_deiodinase_AS. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11781. PTHR11781. 1 hit.
Pfam	PF00837. T4_deiodinase. 1 hit. [Graphical view]
PROSITE	PS01205. T4_DEIODINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOD2_NEOFS

Accession

Primary (citable) accession number: Q8UVX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program