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Q8UVX8

- IOD2_NEOFS

UniProt

Q8UVX8 - IOD2_NEOFS

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Protein

Type II iodothyronine deiodinase

Gene
dio2
Organism
Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) By similarity.

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
  2. thyroid hormone metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:dio2
OrganismiNeoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Taxonomic identifieri7892 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiDipnoiCeratodontiformesCeratodontidaeNeoceratodus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Type II iodothyronine deiodinasePRO_0000318643Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UVX8-1 [UniParc]FASTAAdd to Basket

« Hide

MGLLSVDLLI TLQILPWFFS NCLFLALYDS VVLLKHVILL LSCSKSSRGE    50
WRRMLTSEGL RTVWNSFLLD AYKQVKLGGD APNSKVVRVT SGCCRRRSFS 100
GKGESECHLL DFASSNRPLV VNFGSATUPP FISQLPTFRK LVEEFSDVAD 150
FLLVYIDEAH PADGWAAPGV ATKSFEVKKH RSQEERCVAA HKLLEHFSLP 200
PQCQVVADCM DNNTNVAYGV SFERVCIVQR QKIAYLGGKG PFFYNLKEVR 250
HWLEQTYRKR UVPTCELIM 269
Length:269
Mass (Da):30,513
Last modified:February 26, 2008 - v3
Checksum:i66F17725DF72E62B
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei128 – 1281Selenocysteine
Non-standard residuei261 – 2611Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF327438 mRNA. Translation: AAL56981.2.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF327438 mRNA. Translation: AAL56981.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000099.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Deiodinase type II and tissue specific mRNA alternative splicing in the Australian lungfish, Neoceratodus forsteri."
    Sutija M., Longhurst T.J., Joss J.M.
    Gen. Comp. Endocrinol. 132:409-417(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiIOD2_NEOFS
AccessioniPrimary (citable) accession number: Q8UVX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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