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Protein
Submitted name:

ATP-binding cassette transporter 1

Gene

ABCA1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette transporter 1Imported
Gene namesi
Name:ABCA1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Transmembranei681 – 705HelicalSequence analysisAdd BLAST25
Transmembranei717 – 737HelicalSequence analysisAdd BLAST21
Transmembranei744 – 764HelicalSequence analysisAdd BLAST21
Transmembranei776 – 798HelicalSequence analysisAdd BLAST23
Transmembranei819 – 843HelicalSequence analysisAdd BLAST25
Transmembranei1347 – 1368HelicalSequence analysisAdd BLAST22
Transmembranei1654 – 1676HelicalSequence analysisAdd BLAST23
Transmembranei1696 – 1722HelicalSequence analysisAdd BLAST27
Transmembranei1734 – 1753HelicalSequence analysisAdd BLAST20
Transmembranei1765 – 1789HelicalSequence analysisAdd BLAST25
Transmembranei1852 – 1874HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8UVV4.
PRIDEiQ8UVV4.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036964.

Structurei

3D structure databases

ProteinModelPortaliQ8UVV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini900 – 1131ABC transporterInterPro annotationAdd BLAST232
Domaini1911 – 2143ABC transporterInterPro annotationAdd BLAST233

Sequence similaritiesi

Contains 2 ABC transporter domains.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOVERGENiHBG050436.
KOiK05641.
PhylomeDBiQ8UVV4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030365. ABCA1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF34. PTHR19229:SF34. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UVV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFWTQLGLL LWKNFTYRRR QTFQLLIEVA WPLFIFFILI SVRLSYPPYE
60 70 80 90 100
QHECHFPNKA MPSAGTLPWI QGIICNANNP CFRYPTPGES PGIVGNFNAS
110 120 130 140 150
IVSRLFSDAK RLLLYSQQDT SIKDVQKVLA KLRKLGNSSG LDLKLRDFLV
160 170 180 190 200
DNETFSDFLR HNVSMPSSAV EELLDAEVNL QKVIVSGYRI QLRDLCNSSA
210 220 230 240 250
LSEFLTIQNR SVAMDSEAFL CTLPKETLHA AELAFRANLN PLKPLQREIF
260 270 280 290 300
FNSSLRDLSE TVEALRDSLG KLVKELLSMK SWSDMRQEVM FLTNVNASNS
310 320 330 340 350
STQIYQAVSR IVCGHPEGGG LKIKSLNWYE DNNYKALFGG NSTEDDVTNF
360 370 380 390 400
YDNSTTPYCN ELMKNLESSP LSRIIWRALK PLLIGKVLYT PDTPAIRKIM
410 420 430 440 450
AEVNRTFQEL GVFRDLGGMW EEISPKIWTF MESSQEMDLI RTLLKSKALW
460 470 480 490 500
DLHLPASNWT VEDVARFLSK HPEEFEADNG MVYTWVDAFN ETDRAIQTIS
510 520 530 540 550
RFMECVNLDK LEPVATEVRL INKSLELLDE RRFWAGVVFT EIAPNSTELP
560 570 580 590 600
QHVKYKIRMD IDNVERTNKI KDGYWDPGPR ADPFEDMRYV WGGFTYLQDV
610 620 630 640 650
VEQAIIRVQT GTEKKTGVYV QQMPYPCYVD DIFLRVMSRS MPLFMTLAWI
660 670 680 690 700
YSVAVIIKGI VYEKEARLKE TMRIMGLDNG ILWLSWFISS LIPLLMSAGL
710 720 730 740 750
LVLILKMGNL LPYSDPSVVF VFLSIFGIVT ILQCFLISTV FSRANLAAAC
760 770 780 790 800
GGIVYFTLYL PYVLCVAWQD YVSFSLKIFA SLLSPVAFGF GCEYFALFEE
810 820 830 840 850
QGVGVQWDNF FESPLEEDGF SITTSAVMML FDTFLYGVMT WYIESVFPGQ
860 870 880 890 900
YGIPRPWYFP FTKSYWFGEE SQDRQHLHPD QKGPSEVCKE EEPMHLSLGV
910 920 930 940 950
SIQNLVKVYR DGKKVAVDGL TLNFYEGQIT SFLGHNGAGK TTTMSILTGL
960 970 980 990 1000
FPPTSGTAFI LGKDIRSELS TIRQNLGVCP QHNVLFDLLT VEEHIWFYAR
1010 1020 1030 1040 1050
LKGLPEKKVK EEMEQMAMDV GLPHKLKART SKLSGGMQRK LSVALAFVGG
1060 1070 1080 1090 1100
SKVVILDEPT AGVDPYSRRG IWELLLKYRQ GRTIILSTHH MDEADILGDR
1110 1120 1130 1140 1150
IAIISHGKLC CVGSSLFLKN QLGTGYYLTL VKKDVDSSLS SCRNSSSTVS
1160 1170 1180 1190 1200
YLKKDDSVSQ SSSDAGLGSD HESDTLTIDV SAISNLITKH VPEARLVEDI
1210 1220 1230 1240 1250
GHELTYVLPY KAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK
1260 1270 1280 1290 1300
VADDSGVDAE TSDGTLPARR NRRAFGDRQS CLRPFTEDDA FDPNDSDIDP
1310 1320 1330 1340 1350
ESRETDLLSG MDGKGSYQMK GWKLSQQQFM ALLWKRLLIA KRSRKGFFAQ
1360 1370 1380 1390 1400
IVLPAVFVCI ALMFSLIVPP FGKYPSLELQ PWMYDEQYTF ISNDAPEDAG
1410 1420 1430 1440 1450
TQKLLDALLN KPGFGTRCMQ GHSIPDTPCT VGQKEWTTAS VPDSVLEILR
1460 1470 1480 1490 1500
GNWSMENPSP SCECSNEKIK KMLPVCPPGA GGLPPPQREQ DTADILQNLT
1510 1520 1530 1540 1550
GRNISDYLVK TYAQIIGKSL KNKIWVNEFR YGGFSLGARS SHVLPPSNEV
1560 1570 1580 1590 1600
TDAIKQVKKI LELAQGSSGD RFLNNLASFM KGLDTKNNVK VWFNNKGWHA
1610 1620 1630 1640 1650
IASFLNVINN AILRANLQQG KNPSAYGITA FNHPLNLTKQ QLSEVALMTT
1660 1670 1680 1690 1700
SVDVLVSICV IFAMSFVPAS FVVFLIQERV SKAKHLQFIS GVKPVIYWLA
1710 1720 1730 1740 1750
NFVWDMCNYI VPATLVIIIF ICFQQKSYVS SSNLPVLALL LLLYGWSITP
1760 1770 1780 1790 1800
LMYPASFVFK IPSTAYVVLT SVNLFIGING SVATFVLELF TNNKLNNIND
1810 1820 1830 1840 1850
ILKSVFLIFP HFCLGRGLID MVKNQAMADA LERFGENRFV SPLSWDLVGR
1860 1870 1880 1890 1900
NLFAMAVEGV VFFLITVLIQ YRFFIKPRPV YAKLPPVNDE DEDVNRERQR
1910 1920 1930 1940 1950
IISGGGQSDI LEIRELTKIY RMKRKPAVDR ICVGIPPGEC FGLLGVNGAG
1960 1970 1980 1990 2000
KSSTFKMLTG DTDVTGGDAF LKGNSILSNI QEVHQNMGYC PQFDAVNELL
2010 2020 2030 2040 2050
TGREHLEFFA LLRGVPEKEV CKVGEWAIRK LGLVKYGEKY AGNYSGGNRR
2060 2070 2080 2090 2100
KLSTAIALIG GPPVVFLDEP TTGMDPKARR FLWNCALSVI KEGRSVVLTS
2110 2120 2130 2140 2150
HSMEECEALC TRMAIMVNGR FRCLGSVQHL KNRFGDGYTI VVRIAGGNPD
2160 2170 2180 2190 2200
LKPVEEFFGH AFPGSVLKEK HRNMLQYQLP SSQSSLARIF SVLSQNKKRL
2210 2220 2230 2240 2250
HIEDYSVSQT TLDQVFVNFA KDQSDDDHTK DLSLHKNQTV VDIAILNSFL
2260
QDEKVKESCV
Length:2,260
Mass (Da):254,073
Last modified:March 1, 2002 - v1
Checksum:i19D137F342F98662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362377 mRNA. Translation: AAL56247.1.
RefSeqiNP_989476.1. NM_204145.2.
UniGeneiGga.102.

Genome annotation databases

GeneIDi373945.
KEGGigga:373945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362377 mRNA. Translation: AAL56247.1.
RefSeqiNP_989476.1. NM_204145.2.
UniGeneiGga.102.

3D structure databases

ProteinModelPortaliQ8UVV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036964.

Proteomic databases

PaxDbiQ8UVV4.
PRIDEiQ8UVV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373945.
KEGGigga:373945.

Organism-specific databases

CTDi19.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOVERGENiHBG050436.
KOiK05641.
PhylomeDBiQ8UVV4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030365. ABCA1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF34. PTHR19229:SF34. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8UVV4_CHICK
AccessioniPrimary (citable) accession number: Q8UVV4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.