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Reviewed, UniProtKB/Swiss-Prot Q8UVR8 (CSF12_TAKRU)

Last modified February 9, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Macrophage colony-stimulating factor 1 receptor 2
      Short name=CSF-1-R 2
    EC=2.7.10.1
Gene names
Name: csf1r2
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifier31033 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

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Protein attributes

Sequence length1019 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 10191001Macrophage colony-stimulating factor 1 receptor 2
PRO_0000249008

Regions

Topological domain19 – 576558Extracellular Potential
Transmembrane577 – 59721 Potential
Topological domain598 – 1019422Cytoplasmic Potential
Domain37 – 10973Ig-like C2-type 1
Domain106 – 212107Ig-like C2-type 2
Domain224 – 31289Ig-like C2-type 3
Domain383 – 47492Ig-like C2-type 4
Domain487 – 56781Ig-like C2-type 5
Domain641 – 963323Protein kinase
Nucleotide binding647 – 6559ATP By similarity
Compositional bias418 – 4225Poly-Asn
Compositional bias588 – 5936Poly-Leu
Compositional bias995 – 9984Poly-Glu

Sites

Active site8271Proton acceptor By similarity
Binding site6741ATP By similarity

Amino acid modifications

Modified residue7561Phosphotyrosine; by autocatalysis By similarity
Modified residue8581Phosphotyrosine; by autocatalysis By similarity
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation3461N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation3691N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Disulfide bond52 ↔ 92 Potential
Disulfide bond139 ↔ 193 Potential
Disulfide bond239 ↔ 294 Potential
Disulfide bond490 ↔ 552 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q8UVR8-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 699DEB24A38C2E8B

FASTA1,019114,264
        10         20         30         40         50         60 
MKSYCLLLSI TLSCCCSAED LPDPPSIHLN SKYLPNQAEA ILTAGTPFTL RCTGASSVHW 

        70         80         90        100        110        120 
SSSAFCLLYH GRLVDPIDVQ RADPRHTGTY CCGYTNQSLE HLSTWIHLYV KDPADPSTVF 

       130        140        150        160        170        180 
VTPRNSPRVK EGQDFLYRCL LTDPSVTNLT FQPEDNIQGS GQHLPVGMNV TVDPQRGALI 

       190        200        210        220        230        240 
QDVQRSFSGQ YVCSGWKDGR HFISRSFHLL VAPRLPPPSV AIHQNKAVRL EGEKFEVTCV 

       250        260        270        280        290        300 
SSSTTHLFNV TWTHLTKKNF DVAVTREYRN SHMYISSTLM IAAVSQEDRG TYTCAAASED 

       310        320        330        340        350        360 
GVTTATTHLI VLDSRFMTTY LKTWHANTKA KNKEISKEID GNLTANSTSI DIEANRSSKL 

       370        380        390        400        410        420 
HMKMELIANV STDGVHVNNI SSSTTVEAYE GLDVILTFVT ESYPPLSNQS WTKPTKVNNN 

       430        440        450        460        470        480 
NNVTMYQENY SINDTRSEAS LLLRRVRQED HGSYTFHFSN SFFSGSQNID LRIYRSPSAI 

       490        500        510        520        530        540 
ISVEKNTLTC SSSGYPVPTI AWYSCPGILK TCGNLTTTES SEADPTSEHD EENVRKLLNL 

       550        560        570        580        590        600 
PLSTGGDVTA ECIASNQVGA FRKVFHLREH NSAFMSALIG AGSTAAILFL LLLVVFYKWR 

       610        620        630        640        650        660 
QKPKYEIRWK IIESTEGNHY TFVDPTLLPY NYKWEFPRDK LRLGAVLGSG AFGKVVEATA 

       670        680        690        700        710        720 
YGLGTDDVTR VAVKMLKPRA LSEEREALMS ELKILSHLGY HDNIVNLLGA CTQGGPMLMI 

       730        740        750        760        770        780 
TEYCSYGDLL NFLRARAQDF MASILSADEM EGDPFYKNMA TLYGRLRSDS GISCCSDYQE 

       790        800        810        820        830        840 
MQPILGSAEK QQGVQMGGLS FGDLLSFSHQ VAQGLDFLST RNCIHRDVAA RNVLLTDHRV 

       850        860        870        880        890        900 
AKICDFGLAR DIQNDDSYIV QGNARLPVKW MAPESIFQCV YTVQSDVWSY GVLLWEIFSL 

       910        920        930        940        950        960 
GKSPYPNVAV DTHFYKMIKD GRHMTQPDFA PVEMYQLMTH CWSLEPTDRP TFKMICQLID 

       970        980        990       1000       1010 
RLLQSNDDTN HQSYSNINET KKDDFKGGKS QRRGEEEEQR RQRGNLWIPL SVTNIYQLS

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References

[1]"Identification and analysis of additional copies of the platelet-derived growth factor receptor and colony stimulating factor 1 receptor genes in fugu."
Williams H., Brenner S., Venkatesh B.
Gene 295:255-264(2002) [PubMed: 12354661] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF411927 Genomic DNA. Translation: AAL50568.1.

3D structure databases

HSSPHSSP built from PDB template 1T46 based on UniProtKB P10721.
SMRQ8UVR8. Positions 603-964.
ModBaseSearch...

Genome annotation databases

EnsemblENSTRUT00000006717; ENSTRUP00000006673; ENSTRUG00000002871; Takifugu rubripes. [Genome view]

Phylogenomic databases

eggNOGveNOG09015.
HOVERGENQ8UVR8.
InParanoidQ8UVR8.

Enzyme and pathway databases

BRENDA2.7.10.1. 281122.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR016243. Tyr_prot_kinase_CSF1/PDGF_rcpt.
IPR020729. Tyr_prot_kinase_MCSF1_rcpt.
IPR001824. Tyr_prot_kinase_rcpt_3_CS.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PANTHERPTHR23256. Tyr_prot_kinase. 1 hit.
PTHR23256:SF237. Tyr_prot_kinase_MCSF1_rcpt. 1 hit.
PIRSFPIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCSF12_TAKRU
AccessionPrimary (citable) accession number: Q8UVR8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2002
Last modified: February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents