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Protein

Vang-like protein 2

Gene

vangl2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural progenitor cell morphogenesis, segregation of somites and adaxial cell development. Together with prickle1, required for the posterior (caudal) movement of branchiomotor neurons in the hindbrain independently of, and a few hours after, convergent extension (PubMed:11780127, Ref. 2, PubMed:9007230, PubMed:9007234, PubMed:9007236, PubMed:9808788, PubMed:10996075, PubMed:10992326, PubMed:11820812, PubMed:12105418, PubMed:12874125, PubMed:15829519, PubMed:16407953, PubMed:17239849). May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity).By similarity14 Publications

GO - Biological processi

  • actin filament organization Source: ZFIN
  • anterior/posterior axon guidance Source: ZFIN
  • axis elongation Source: ZFIN
  • canonical Wnt signaling pathway Source: UniProtKB
  • cell migration in hindbrain Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • cell morphogenesis Source: ZFIN
  • cilium assembly Source: ZFIN
  • cilium organization Source: ZFIN
  • cloaca development Source: ZFIN
  • commissural neuron axon guidance Source: ZFIN
  • convergent extension Source: ZFIN
  • convergent extension involved in axis elongation Source: ZFIN
  • convergent extension involved in gastrulation Source: UniProtKB
  • dorsal convergence Source: ZFIN
  • embryonic eye morphogenesis Source: ZFIN
  • establishment of cell polarity Source: ZFIN
  • establishment of mitotic spindle orientation Source: ZFIN
  • establishment of planar polarity Source: ZFIN
  • establishment or maintenance of cell polarity Source: UniProtKB
  • extracellular matrix organization Source: ZFIN
  • eye development Source: UniProtKB
  • left/right pattern formation Source: ZFIN
  • motor neuron migration Source: ZFIN
  • muscle cell migration Source: ZFIN
  • neural plate morphogenesis Source: ZFIN
  • neural tube development Source: UniProtKB
  • neural tube formation Source: ZFIN
  • neuron migration Source: UniProtKB
  • notochord development Source: UniProtKB
  • notochord morphogenesis Source: ZFIN
  • otolith development Source: ZFIN
  • photoreceptor cell outer segment organization Source: ZFIN
  • positive regulation of Wnt signaling pathway, calcium modulating pathway Source: UniProtKB
  • post-anal tail morphogenesis Source: ZFIN
  • regulation of Wnt signaling pathway Source: UniProtKB
  • somitogenesis Source: UniProtKB
  • striated muscle cell development Source: ZFIN
  • Wnt signaling pathway, planar cell polarity pathway Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Gastrulation, Neurogenesis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Vang-like protein 2
Alternative name(s):
Protein strabismus
Protein trilobite
Van Gogh-like protein 2
Gene namesi
Name:vangl2Imported
Synonyms:stbm1 Publication, tri1 Publication
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-020507-3. vangl2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 109CytoplasmicSequence analysisAdd BLAST109
Transmembranei110 – 130Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini131 – 148ExtracellularSequence analysisAdd BLAST18
Transmembranei149 – 169Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini170 – 178CytoplasmicSequence analysis9
Transmembranei179 – 199Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini200 – 215ExtracellularSequence analysisAdd BLAST16
Transmembranei216 – 236Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini237 – 526CytoplasmicSequence analysisAdd BLAST290

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi517 – 526Missing : No effect on dvl2/dsh-binding. 1 Publication10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837301 – 526Vang-like protein 2Add BLAST526

Proteomic databases

PaxDbiQ8UVJ6.
PRIDEiQ8UVJ6.

Expressioni

Tissue specificityi

Ubiquitously expressed at the 4-cell stage. In early somitogenesis, becomes more abundant in anterior neural tissue where expression is seen in the neural tube but not in the notochord.1 Publication

Developmental stagei

Expressed both maternally and zygotically, with expression peaking at the neurula stage.1 Publication

Gene expression databases

BgeeiENSDARG00000027397.

Interactioni

Subunit structurei

Interacts with the PDZ domain of dvl2/dsh.1 Publication

Protein-protein interaction databases

BioGridi79765. 1 interactor.
STRINGi7955.ENSDARP00000031546.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi523 – 526PDZ-bindingSequence analysis4

Sequence similaritiesi

Belongs to the Vang family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3814. Eukaryota.
ENOG410XPVT. LUCA.
GeneTreeiENSGT00390000012496.
HOGENOMiHOG000230590.
HOVERGENiHBG058215.
InParanoidiQ8UVJ6.
KOiK04510.
OMAiTIQYHKD.
OrthoDBiEOG091G056W.
PhylomeDBiQ8UVJ6.
TreeFamiTF313467.

Family and domain databases

InterProiView protein in InterPro
IPR009539. VANGL.
PANTHERiPTHR20886. PTHR20886. 1 hit.
PfamiView protein in Pfam
PF06638. Strabismus. 1 hit.
PIRSFiPIRSF007991. Strabismus. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNESQYSGY SYKSSHSRSS RKHRDRRDRH RSKSRDSSSR GDKSVTIQAP
60 70 80 90 100
GEPLLDAEST RGDDRDDNWG ETTTVVTGTS EHSVSNEDLT RASKELEDSS
110 120 130 140 150
PLECRRFAGP IVSGVLGLFA LLTPLAFLLL PQLLWRDSLE PCGTPCEGLY
160 170 180 190 200
VSLAFKLLVL LISSWALFLR PSRSTLPRFF VFRCLLMALV FLFVASYWLF
210 220 230 240 250
YGVRVLEPRE RDYRGIVGYA VSLVDALLFI QYLALVLLEV RHLRPAFCLK
260 270 280 290 300
VVRTTDGASR FYNVGHLSIQ RAAVWVLDHY YTDFPVYNPA LLNLPKSILS
310 320 330 340 350
KKMSGFKVYS LGEENSTNNS TGQSRAMIAA AARRRDNSHN EYYYEEAEMD
360 370 380 390 400
RRVRKRKARL VVAVEEAFTH IKRLQDDEAA ASPKHPREVM DPREAAQAIF
410 420 430 440 450
APMARAMQKY LRTTRQQPYH SMESIISHLQ FCITHNMTPK AFLERYLTPG
460 470 480 490 500
PTMQYQRENG RGRQWTLVSE EPVTAALRQG LVFSLRRLDF ALVVTVTPLP
510 520
FLNLGEEFID PKSHKFVMRL QSETSV
Length:526
Mass (Da):60,082
Last modified:March 1, 2002 - v1
Checksum:i3B2FA8D5E2939431
GO

Sequence cautioni

The sequence AAH65983 differs from that shown. Sequence differs from that shown at the C-terminus, most likely because of a sequence artifact.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF428249 mRNA. Translation: AAL30891.1.
BC065983 mRNA. Translation: AAH65983.1. Sequence problems.
RefSeqiNP_705960.1. NM_153674.1.
UniGeneiDr.91583.

Genome annotation databases

EnsembliENSDART00000033316; ENSDARP00000031546; ENSDARG00000027397.
ENSDART00000171486; ENSDARP00000131315; ENSDARG00000027397.
GeneIDi245949.
KEGGidre:245949.

Similar proteinsi

Entry informationi

Entry nameiVANG2_DANRE
AccessioniPrimary (citable) accession number: Q8UVJ6
Secondary accession number(s): Q6NZS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families