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Protein
Submitted name:

HNF1 homeobox a

Gene

hnf1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 266HomeoboxPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • DNA binding Source: ZFIN
  • protein dimerization activity Source: ZFIN
  • transcription factor activity, sequence-specific DNA binding Source: ZFIN

GO - Biological processi

  • endocrine pancreas development Source: ZFIN
  • positive regulation of transcription, DNA-templated Source: InterPro
  • type B pancreatic cell development Source: ZFIN

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
HNF1 homeobox aImported
Submitted name:
Hepatocyte nuclear factor 1-alphaImported
Gene namesi
Name:hnf1aImported
Synonyms:tcf1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-021206-12. hnf1a.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: ZFIN

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Interactioni

GO - Molecular functioni

  • protein dimerization activity Source: ZFIN

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 265Homeobox DNA-bindingInterPro annotationAdd BLAST82

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationImported

Phylogenomic databases

eggNOGiENOG410IFA0. Eukaryota.
ENOG410ZZZ0. LUCA.
HOGENOMiHOG000015305.
HOVERGENiHBG005980.
KOiK08036.

Family and domain databases

InterProiView protein in InterPro
IPR006899. HNF-1_N.
IPR006898. HNF1a_C.
IPR006897. HNF1b_C.
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
PfamiView protein in Pfam
PF04814. HNF-1_N. 1 hit.
PF04813. HNF-1A_C. 1 hit.
PF04812. HNF-1B_C. 1 hit.
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UVH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGGESRRSE GSGRLSALQE QLVWSLLGSG LSKELLIQAM GDLERERASS
60 70 80 90 100
GGERADRADC ESSEEGEMDN PPPIYRELEK LPPEEAARQR AQVDQLLQED
110 120 130 140 150
PWHVAKMVKS YMQQHNLPQR EVVESTGLNQ SHLSQHLNKG TPMKNQKRAA
160 170 180 190 200
LYSWYTKKQA EISQQFTNAS RGVMSGEEPG EDVRKGRRNR FKWGPASLQI
210 220 230 240 250
LFQAYERQKN PSKEEREGLV EECNRAECLQ RGVSPSQLAG LGSNLVTEVR
260 270 280 290 300
VYNWFANRRK EEAFRHKLAL DVPYSSQSAA STCQTLPSSP SPGLKYSQTV
310 320 330 340 350
VCESLGTVRS SGGEDRGASV RLASPVQLEP SHTLLETHHH KPASVGGSLP
360 370 380 390 400
PVSTLTSLHG MSGSSAGAPG LFIPSVMSLG DSSLLIGLTS SQPQTVPIIN
410 420 430 440 450
NVGGGFTTLQ PISFQQPLHA SPQQPIAQQL QSHIAPSSFM ATMAQLPCHM
460 470 480 490 500
YSKADLSSYP SSSLLSQAMV IADSSSIGTL TNLTAVRQIL TTDPEGHTES
510 520 530 540 550
AIEEESLHLQ STSPEPGSSG SLDLYPQSQT SETHSSHLQL SSPAGDIDPY
560
IPAQMVSTAQ
Length:560
Mass (Da):60,701
Last modified:March 1, 2002 - v1
Checksum:iB0B81BBC6208A966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC163270 mRNA. Translation: AAI63270.1.
BC163280 mRNA. Translation: AAI63280.1.
AF442956 mRNA. Translation: AAL48219.1.
AF244934 mRNA. Translation: AAL82895.1.
RefSeqiNP_739570.1. NM_170764.1.
UniGeneiDr.85278.

Genome annotation databases

GeneIDi266961.
KEGGidre:266961.

Similar proteinsi

Entry informationi

Entry nameiQ8UVH4_DANRE
AccessioniPrimary (citable) accession number: Q8UVH4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)