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Protein
Submitted name:

HNF1 homeobox a

Gene

hnf1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: ZFIN
  • protein dimerization activity Source: ZFIN
  • transcription factor activity, sequence-specific DNA binding Source: ZFIN

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
HNF1 homeobox aImported
Submitted name:
Hepatocyte nuclear factor 1-alphaImported
Gene namesi
Name:hnf1aImported
Synonyms:tcf1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-021206-12. hnf1a.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

  • nucleus Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

GO - Molecular functioni

  • protein dimerization activity Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000006784.

Structurei

3D structure databases

ProteinModelPortaliQ8UVH4.
SMRiQ8UVH4. Positions 74-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 26582Homeobox DNA-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

HomeoboxUniRule annotationImported

Phylogenomic databases

eggNOGiENOG410IFA0. Eukaryota.
ENOG410ZZZ0. LUCA.
HOGENOMiHOG000015305.
HOVERGENiHBG005980.
KOiK08036.
PhylomeDBiQ8UVH4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR006899. HNF-1_N.
IPR006898. HNF1a_C.
IPR006897. HNF1b_C.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF04814. HNF-1_N. 1 hit.
PF04813. HNF-1A_C. 1 hit.
PF04812. HNF-1B_C. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UVH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGGESRRSE GSGRLSALQE QLVWSLLGSG LSKELLIQAM GDLERERASS
60 70 80 90 100
GGERADRADC ESSEEGEMDN PPPIYRELEK LPPEEAARQR AQVDQLLQED
110 120 130 140 150
PWHVAKMVKS YMQQHNLPQR EVVESTGLNQ SHLSQHLNKG TPMKNQKRAA
160 170 180 190 200
LYSWYTKKQA EISQQFTNAS RGVMSGEEPG EDVRKGRRNR FKWGPASLQI
210 220 230 240 250
LFQAYERQKN PSKEEREGLV EECNRAECLQ RGVSPSQLAG LGSNLVTEVR
260 270 280 290 300
VYNWFANRRK EEAFRHKLAL DVPYSSQSAA STCQTLPSSP SPGLKYSQTV
310 320 330 340 350
VCESLGTVRS SGGEDRGASV RLASPVQLEP SHTLLETHHH KPASVGGSLP
360 370 380 390 400
PVSTLTSLHG MSGSSAGAPG LFIPSVMSLG DSSLLIGLTS SQPQTVPIIN
410 420 430 440 450
NVGGGFTTLQ PISFQQPLHA SPQQPIAQQL QSHIAPSSFM ATMAQLPCHM
460 470 480 490 500
YSKADLSSYP SSSLLSQAMV IADSSSIGTL TNLTAVRQIL TTDPEGHTES
510 520 530 540 550
AIEEESLHLQ STSPEPGSSG SLDLYPQSQT SETHSSHLQL SSPAGDIDPY
560
IPAQMVSTAQ
Length:560
Mass (Da):60,701
Last modified:March 1, 2002 - v1
Checksum:iB0B81BBC6208A966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC163270 mRNA. Translation: AAI63270.1.
BC163280 mRNA. Translation: AAI63280.1.
AF442956 mRNA. Translation: AAL48219.1.
AF244934 mRNA. Translation: AAL82895.1.
RefSeqiNP_739570.1. NM_170764.1.
UniGeneiDr.85278.

Genome annotation databases

GeneIDi266961.
KEGGidre:266961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC163270 mRNA. Translation: AAI63270.1.
BC163280 mRNA. Translation: AAI63280.1.
AF442956 mRNA. Translation: AAL48219.1.
AF244934 mRNA. Translation: AAL82895.1.
RefSeqiNP_739570.1. NM_170764.1.
UniGeneiDr.85278.

3D structure databases

ProteinModelPortaliQ8UVH4.
SMRiQ8UVH4. Positions 74-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000006784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266961.
KEGGidre:266961.

Organism-specific databases

CTDi6927.
ZFINiZDB-GENE-021206-12. hnf1a.

Phylogenomic databases

eggNOGiENOG410IFA0. Eukaryota.
ENOG410ZZZ0. LUCA.
HOGENOMiHOG000015305.
HOVERGENiHBG005980.
KOiK08036.
PhylomeDBiQ8UVH4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR006899. HNF-1_N.
IPR006898. HNF1a_C.
IPR006897. HNF1b_C.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF04814. HNF-1_N. 1 hit.
PF04813. HNF-1A_C. 1 hit.
PF04812. HNF-1B_C. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish."
    Gong H.-Y., Lin C.J.-F., Chen M.H.-C., Hu M.-C., Lin G.-H., Zhou Y., Zon L.I., Wu J.-L.
    Gene 338:35-46(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: GutImported.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiQ8UVH4_DANRE
AccessioniPrimary (citable) accession number: Q8UVH4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.