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Protein
Submitted name:

Alpha A crystallin

Gene

cryaa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • structural constituent of eye lens Source: ZFIN
  • unfolded protein binding Source: ZFIN

GO - Biological processi

  • eye development Source: ZFIN
  • lens development in camera-type eye Source: ZFIN
  • visual perception Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha A crystallinImported
Submitted name:
Cryaa proteinImported
Submitted name:
Crystallin, alpha AImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:cryaaImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-020508-1. cryaa.

Expressioni

Gene expression databases

BgeeiENSDARG00000053502.

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070021.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N3EX-ray1.75A/B61-166[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 146HSP20InterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
KOiK09541.
OMAiAIMDSAG.
OrthoDBiEOG091G0USC.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012274. Alpha-crystallin_A.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF36. PTHR11527:SF36. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UUZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIAIQHPWF RRTLGYPTRL FDQFFGEGLF DYDLFPFTTS TVSPYYRHSL
60 70 80 90 100
FRNILDSSNS GVSEVRSDRE KFTVYLDVKH FSPDELSVKV TDDYVEIQGK
110 120 130 140 150
HGERQDDHGY ISREFHRRYR LPSNVDQSAI TCTLSADGLL TLCGPKTSGI
160 170
DAGRGDRTIP VTREDKSNSG SSS
Length:173
Mass (Da):19,714
Last modified:March 1, 2002 - v1
Checksum:i301D743DB91BBC13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248514 Genomic DNA. No translation available.
BC083177 mRNA. Translation: AAH83177.1.
BC164886 mRNA. Translation: AAI64886.1.
AY035778 mRNA. Translation: AAK61363.1.
RefSeqiNP_694482.1. NM_152950.2.
UniGeneiDr.78315.

Genome annotation databases

EnsembliENSDART00000075539; ENSDARP00000070021; ENSDARG00000053502.
GeneIDi100000769.
KEGGidre:100000769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248514 Genomic DNA. No translation available.
BC083177 mRNA. Translation: AAH83177.1.
BC164886 mRNA. Translation: AAI64886.1.
AY035778 mRNA. Translation: AAK61363.1.
RefSeqiNP_694482.1. NM_152950.2.
UniGeneiDr.78315.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N3EX-ray1.75A/B61-166[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000075539; ENSDARP00000070021; ENSDARG00000053502.
GeneIDi100000769.
KEGGidre:100000769.

Organism-specific databases

CTDi1409.
ZFINiZDB-GENE-020508-1. cryaa.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
KOiK09541.
OMAiAIMDSAG.
OrthoDBiEOG091G0USC.
TreeFamiTF105049.

Gene expression databases

BgeeiENSDARG00000053502.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012274. Alpha-crystallin_A.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF36. PTHR11527:SF36. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8UUZ6_DANRE
AccessioniPrimary (citable) accession number: Q8UUZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.