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Protein

Protein mab-21-like 2

Gene

mab21l2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells.1 Publication

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • embryonic cranial skeleton morphogenesis Source: ZFIN
  • embryonic eye morphogenesis Source: ZFIN
  • eye development Source: UniProtKB
  • lens development in camera-type eye Source: ZFIN
  • retina development in camera-type eye Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mab-21-like 2
Gene namesi
Name:mab21l2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-011101-3. mab21l2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Protein mab-21-like 2PRO_0000312789Add
BLAST

Proteomic databases

PaxDbiQ8UUZ1.

Expressioni

Developmental stagei

Expressed from 11 hours post-fertilization (hpf). Expression in the midbrain and optic primordia begins at the onset of segmentation and increases to 14 hpf, remaining strong during lateral migration of the optic primordia. Expressed in the neural tube and the oblongated retinal epithelium from 18 hpf. Expression within the differentiating eyes subsequently decreases from 22 hpf to 35 hpf, with only weak expression at the edge of the lens observed from 35 hpf to 48 hpf. Expressed in the branchial pouches from 22 hpf, and in the pharyngeal arches, ganglia and hindbrain and spinal cord neurons from 24 hpf. Expressed in the lens perimeter and the differentiated amacrine and ganglion cell layers at 72 hpf.4 Publications

Gene expression databases

BgeeiQ8UUZ1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000019528.

Family & Domainsi

Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00510000046791.
HOGENOMiHOG000007337.
HOVERGENiHBG053080.
InParanoidiQ8UUZ1.
OMAiWDESCIA.
OrthoDBiEOG7F24SW.
PhylomeDBiQ8UUZ1.
TreeFamiTF315012.

Family and domain databases

InterProiIPR020950. Mab-21-like_1/2.
IPR024810. Mab-21_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
PANTHERiPTHR10656:SF37. PTHR10656:SF37. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UUZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIATQAKLVY QLNKYYNERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP
60 70 80 90 100
RFISSLSEID ARYEGMEVIA PNEFEVVLYL NQMGVFNFVD DGSLPGCAVL
110 120 130 140 150
KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK
160 170 180 190 200
MVADTSEVKL RIRERYVVQI TPAFKCTGIW PRSAAQWPMP HIPWPGPNRV
210 220 230 240 250
AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFAEAENR LLMSGCRKKC
260 270 280 290 300
LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDESCLGDRL
310 320 330 340 350
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALETAAK QTWRLAREIL

TNAKSLDKL
Length:359
Mass (Da):41,014
Last modified:March 1, 2002 - v1
Checksum:iB1E7B8CE3709337C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038031 mRNA. Translation: AAK71495.1.
AY048748 Genomic DNA. Translation: AAL09174.1.
BC065628 mRNA. Translation: AAH65628.1.
RefSeqiNP_694507.1. NM_152975.2.
UniGeneiDr.15056.

Genome annotation databases

EnsembliENSDART00000014608; ENSDARP00000019528; ENSDARG00000015266.
GeneIDi117234.
KEGGidre:117234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038031 mRNA. Translation: AAK71495.1.
AY048748 Genomic DNA. Translation: AAL09174.1.
BC065628 mRNA. Translation: AAH65628.1.
RefSeqiNP_694507.1. NM_152975.2.
UniGeneiDr.15056.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000019528.

Proteomic databases

PaxDbiQ8UUZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000014608; ENSDARP00000019528; ENSDARG00000015266.
GeneIDi117234.
KEGGidre:117234.

Organism-specific databases

CTDi10586.
ZFINiZDB-GENE-011101-3. mab21l2.

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00510000046791.
HOGENOMiHOG000007337.
HOVERGENiHBG053080.
InParanoidiQ8UUZ1.
OMAiWDESCIA.
OrthoDBiEOG7F24SW.
PhylomeDBiQ8UUZ1.
TreeFamiTF315012.

Miscellaneous databases

PROiQ8UUZ1.

Gene expression databases

BgeeiQ8UUZ1.

Family and domain databases

InterProiIPR020950. Mab-21-like_1/2.
IPR024810. Mab-21_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
PANTHERiPTHR10656:SF37. PTHR10656:SF37. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards."
    Kudoh T., Dawid I.B.
    Mech. Dev. 109:95-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "Expression of zebrafish mab21 genes marks the differentiating eye, midbrain and neural tube."
    Wong Y.-M., Chow K.L.
    Mech. Dev. 113:149-152(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  5. "A role for GnRH in early brain regionalization and eye development in zebrafish."
    Wu S., Page L., Sherwood N.M.
    Mol. Cell. Endocrinol. 257:47-64(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiMB212_DANRE
AccessioniPrimary (citable) accession number: Q8UUZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.