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Protein

Glycosylated Gag polyprotein

Gene

gag

Organism
Moloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Seems to be important for efficient replication in vivo.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri590 – 607CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylated Gag polyprotein
Short name:
Pr80gag
Alternative name(s):
Glyco-gag
gp80gag
Cleaved into the following 2 chains:
Gene namesi
Name:gag
OrganismiMoloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)
Taxonomic identifieri882209 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

CA-NC :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 86HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000390851? – 626CA-NC
ChainiPRO_00003908501 – 626Glycosylated Gag polyproteinAdd BLAST626
ChainiPRO_50000618081 – ?Nextended-MA-p12Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi113N-linked (GlcNAc...); by hostSequence analysis1
Modified residuei280Phosphoserine; by hostBy similarity1
Glycosylationi505N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

May be cleaved within the capsid domain.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili526 – 566Sequence analysisAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi199 – 202PTAP/PSAP motif4
Motifi250 – 253PPXY motif4
Motifi383 – 385Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 281Pro-richAdd BLAST123

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri590 – 607CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3Di1.10.150.180. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000840. G_retro_matrix.
IPR002079. Gag_p12.
IPR003036. Gag_P30.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF01140. Gag_MA. 1 hit.
PF01141. Gag_p12. 1 hit.
PF02093. Gag_p30. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Pr80gag (identifier: Q8UN02-1) [UniParc]FASTAAdd to basket
Also known as: GlycoGag

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
LGDVPGTSGA VFVARPESKN PDRFGLFGAP PLEEGYVVLV GDENLKQFPP
60 70 80 90 100
PSEFLLSVWN RSRAARLVCC SIVLCCLCLT VFLYLSENMG QTVTTPLSLT
110 120 130 140 150
LDHWKDVERI AHNQSVDVKK RRWVTFCSAE WPTFNVGWPR DGTFNRDLIT
160 170 180 190 200
QVKIKVFSPG PHGHPDQVPY IVTWEALAFD PPPWAKPFVH PKPPPPLPPS
210 220 230 240 250
APSLPLEPPL STPSRSSLYP ALTPSLGAKP KPQVLSDSEG PLIDLLTEDP
260 270 280 290 300
PPYRDPRPPP SDGDGNSGEA TPAGEAPDPS PMASRLRGRR EPPVADSTTS
310 320 330 340 350
QAFPLRTGGN GQLQYWPFSS SDLYNWKNNN PSFSEDPGKL TALIESVLIT
360 370 380 390 400
HQPTWDDCQQ LLGTLLTGEE KQRVLLEARK AVRGDDGRPT QLPNEVDAAF
410 420 430 440 450
PLERPDWEYT TQAGRNHLVQ YRQLLLAGLQ NAGRSPTNLA KVKGITQGPN
460 470 480 490 500
ESPSAFLERL KEAYRRYTPY DPEDPGQETN VAMSFIWQSA PDIGRKLERL
510 520 530 540 550
EDLKNKTLGD LVREAERIFN KRETPEEREE RIRRETEEKE ERRRTEDEQK
560 570 580 590 600
EKERDRRRHR EMSKLLATVV SGQRQDRQGG ERRRSQLDRD QCAYCKEKGH
610 620
WAKDCPKKPR GPRGPRPQTS LLTLDD
Note: Produced by an upstream CUG initiation codon.
Length:626
Mass (Da):70,485
Last modified:October 14, 2015 - v2
Checksum:i9F16BAA64EDD4F10
GO
Isoform Pr65gag (identifier: P03332-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P03332.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:538
Mass (Da):60,858
GO

Sequence cautioni

The sequence AAL69908 differs from that shown.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462057 Genomic DNA. Translation: AAL69908.1. Sequence problems.
PIRiS02769.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462057 Genomic DNA. Translation: AAL69908.1. Sequence problems.
PIRiS02769.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.150.180. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000840. G_retro_matrix.
IPR002079. Gag_p12.
IPR003036. Gag_P30.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF01140. Gag_MA. 1 hit.
PF01141. Gag_p12. 1 hit.
PF02093. Gag_p30. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAG80_MLVMN
AccessioniPrimary (citable) accession number: Q8UN02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: October 14, 2015
Last modified: November 2, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.