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Q8UN02

- GAG80_MLVMN

UniProt

Q8UN02 - GAG80_MLVMN

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Protein

Glycosylated Gag polyprotein

Gene

gag

Organism
Moloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Seems to be important for efficient replication in vivo.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri590 – 60718CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. structural molecule activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. virion assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylated Gag polyprotein
Short name:
Pr80gag
Alternative name(s):
Glyco-gag
gp80gag
Cleaved into the following 2 chains:
Gene namesi
Name:gag
OrganismiMoloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)
Taxonomic identifieri882209 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 626CA-NCPRO_0000390851
Chaini1 – 626626Glycosylated Gag polyproteinPRO_0000390850Add
BLAST
Chaini1 – ?Nextended-MA-p12Sequence AnalysisPRO_5000061808

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...); by hostSequence Analysis
Modified residuei280 – 2801Phosphoserine; by hostBy similarity
Glycosylationi505 – 5051N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

May be cleaved within the capsid domain.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8UN02.
SMRiQ8UN02. Positions 90-186, 304-435, 440-470, 580-619.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili526 – 56641Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi199 – 2024PTAP/PSAP motif
Motifi250 – 2534PPXY motif
Motifi383 – 3853Cell attachment siteSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi159 – 281123Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri590 – 60718CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3Di1.10.150.180. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000840. G_retro_matrix_N.
IPR002079. Gag_p12.
IPR003036. Gag_P30.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF01140. Gag_MA. 1 hit.
PF01141. Gag_p12. 1 hit.
PF02093. Gag_p30. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform Pr80gag (identifier: Q8UN02) [UniParc]FASTAAdd to Basket

Also known as: GlycoGag

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDVPGTSGA VFVARPESKN PDRFGLFGAP PLEEGYVVLV GDENLKQFPP
60 70 80 90 100
PSEFLLSVWN RSRAARLVCC SIVLCCLCLT VFLYLSENMG QTVTTPLSLT
110 120 130 140 150
LDHWKDVERI AHNQSVDVKK RRWVTFCSAE WPTFNVGWPR DGTFNRDLIT
160 170 180 190 200
QVKIKVFSPG PHGHPDQVPY IVTWEALAFD PPPWAKPFVH PKPPPPLPPS
210 220 230 240 250
APSLPLEPPL STPSRSSLYP ALTPSLGAKP KPQVLSDSEG PLIDLLTEDP
260 270 280 290 300
PPYRDPRPPP SDGDGNSGEA TPAGEAPDPS PMASRLRGRR EPPVADSTTS
310 320 330 340 350
QAFPLRTGGN GQLQYWPFSS SDLYNWKNNN PSFSEDPGKL TALIESVLIT
360 370 380 390 400
HQPTWDDCQQ LLGTLLTGEE KQRVLLEARK AVRGDDGRPT QLPNEVDAAF
410 420 430 440 450
PLERPDWEYT TQAGRNHLVQ YRQLLLAGLQ NAGRSPTNLA KVKGITQGPN
460 470 480 490 500
ESPSAFLERL KEAYRRYTPY DPEDPGQETN VAMSFIWQSA PDIGRKLERL
510 520 530 540 550
EDLKNKTLGD LVREAERIFN KRETPEEREE RIRRETEEKE ERRRTEDEQK
560 570 580 590 600
EKERDRRRHR EMSKLLATVV SGQRQDRQGG ERRRSQLDRD QCAYCKEKGH
610 620
WAKDCPKKPR GPRGPRPQTS LLTLDD

Note: Produced by an upstream CUG initiation codon.

Length:626
Mass (Da):70,503
Last modified:March 1, 2002 - v1
Checksum:i447798AB667622A6
GO
Isoform Pr65gag (identifier: P03332-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P03332.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:538
Mass (Da):60,858
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462057 Genomic DNA. Translation: AAL69908.1.
PIRiS02769.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462057 Genomic DNA. Translation: AAL69908.1 .
PIRi S02769.

3D structure databases

ProteinModelPortali Q8UN02.
SMRi Q8UN02. Positions 90-186, 304-435, 440-470, 580-619.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.150.180. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR000840. G_retro_matrix_N.
IPR002079. Gag_p12.
IPR003036. Gag_P30.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF01140. Gag_MA. 1 hit.
PF01141. Gag_p12. 1 hit.
PF02093. Gag_p30. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view ]
SMARTi SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEi PS50158. ZF_CCHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of a neuropathogenic variant of Moloney murine leukemia virus ts1: evidence for recombination."
    Szurek P.F., Vann J.M., Brooks B.R.
    Virus Genes 25:343-344(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus."
    Prats A.C., De Billy G., Wang P., Darlix J.L.
    J. Mol. Biol. 205:363-372(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE INITIATION.
  3. "Mutation in the glycosylated gag protein of murine leukemia virus results in reduced in vivo infectivity and a novel defect in viral budding or release."
    Low A., Datta S., Kuznetsov Y., Jahid S., Kothari N., McPherson A., Fan H.
    J. Virol. 81:3685-3692(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGAG80_MLVMN
AccessioniPrimary (citable) accession number: Q8UN02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3