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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathway: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciAGRO:ATU0017-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:Atu0017
ORF Names:AGR_C_26
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813 Componenti: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu0017.

Structurei

3D structure databases

ProteinModelPortaliQ8UJB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0135.
HOGENOMiHOG000161598.
KOiK01817.
OMAiDILQLHG.
OrthoDBiEOG6N94DF.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UJB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPDIKICGL KTPETLERVV RRGASHVGFI FFEKSPRYIE PDLAGRLAEA
60 70 80 90 100
ARGAAKVVAV TVDADNDYLD EIVDLVRPDI LQLHGSESPE RLLHIKALYG
110 120 130 140 150
LPVMKAISIR DAADLAKIEP YIGIADRFLL DAKAPAGSDL PGGNGVSFDW
160 170 180 190 200
TILRSLDESV DYMLSGGLNK DNVAEALAET RASGLDLSSG VESAPGVKDL
210 220
SKIDAFFDVV NDWSKGPKGA
Length:220
Mass (Da):23,633
Last modified:June 1, 2002 - v1
Checksum:i7B9F3BF478E32969
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK85842.1.
PIRiA97361.
AB2579.
RefSeqiNP_353057.1. NC_003062.2.
WP_010970605.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK85842; AAK85842; Atu0017.
GeneIDi1132055.
KEGGiatu:Atu0017.
PATRICi20809724. VBIAgrTum91616_0018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK85842.1.
PIRiA97361.
AB2579.
RefSeqiNP_353057.1. NC_003062.2.
WP_010970605.1. NC_003062.2.

3D structure databases

ProteinModelPortaliQ8UJB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu0017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK85842; AAK85842; Atu0017.
GeneIDi1132055.
KEGGiatu:Atu0017.
PATRICi20809724. VBIAgrTum91616_0018.

Phylogenomic databases

eggNOGiCOG0135.
HOGENOMiHOG000161598.
KOiK01817.
OMAiDILQLHG.
OrthoDBiEOG6N94DF.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
BioCyciAGRO:ATU0017-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiTRPF_AGRFC
AccessioniPrimary (citable) accession number: Q8UJB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.