Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8UJ99 (SAHH_AGRT5)

Last modified February 9, 2010. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenosylhomocysteinase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
      Short name=AdoHcyase
Gene names
Name: ahcY
Ordered Locus Names: Atu0029
ORF Names: AGR_C_46
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: HAMAP

binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Adenosylhomocysteinase HAMAP MF_00563
PRO_0000116939

Regions

Region219 – 384166NAD binding By similarity

Sites

Binding site571Substrate By similarity
Binding site1321Substrate By similarity
Binding site1921Substrate By similarity
Binding site2221Substrate By similarity
Binding site2261Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UJ99-1 [UniParc].

Last modified June 6, 2002. Version 1.
Checksum: 9A124B3304419F26

FASTA46651,160
        10         20         30         40         50         60 
MSLEKDYIVA DINLAAFGRK ELDIAETEMP GLMSCRKEFG ESKPLKGARI TGSLHMTIQT 

        70         80         90        100        110        120 
GVLIETLKEL GAEIRWASCN IFSTQDHAAA AIAAAGIPVF AVKGESLTEY WEYTDKIFQW 

       130        140        150        160        170        180 
TDGGLSNMIL DDGGDATMYI LLGARAEAGE DVLSNPGSEE EEILFAQINK RLKASPGWFT 

       190        200        210        220        230        240 
KQRDALKGVT EETTTGVHRL YDLAKKGLLP FPAINVNDSV TKSKFDNKYG CKESLVDGIR 

       250        260        270        280        290        300 
RATDVMMAGK VAVVCGYGDV GKGSAASLQG AGARVKVTEI DPICALQAAM DGFEVVRLED 

       310        320        330        340        350        360 
VVSSADIFIT TTGNKDVIRI EHMREMKDMA IVGNIGHFDN EIQVASLRNL KWTNIKPQVD 

       370        380        390        400        410        420 
MIEFPKGNRI ILLSEGRLLN LGNATGHPSF VMSASFTNQV LGQIELFTKP GEYKNEVYVL 

       430        440        450        460 
PKHLDEKVAR LHLEKLGVRL TELSDLQADY IGISKQGPFK AEHYRY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK85853.1.
PIRAF2580.
D97362.
RefSeqNP_353068.1.

3D structure databases

SMRQ8UJ99. Positions 5-466.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8UJ99.

Genome annotation databases

GeneID1132067.
GenomeReviewsGene locus Atu0029 in contig AE007869_GR.
KEGGatc:AGR_C_46.
atu:Atu0029.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0499.
HOGENOMHBG352029.
OMAVITHDHM.
PhylomeDBQ8UJ99.

Enzyme and pathway databases

BioCycATUM176299-1:ATU0029-MONOMER.

Family and domain databases

HAMAPMF_00563_B. AdoHcyase_B.
[Tree]
InterProIPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR000043. S-Ado-L-homoCys_hydrolase.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMsTIGR00936. ahcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_AGRT5
AccessionPrimary (citable) accession number: Q8UJ99
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents