Q8UJ09 (DEOC_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	Atu0132
ORF Names:	AGR_C_211

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970)

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00592
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
Sequence caution	The sequence AAK85953.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_0000057294
Sites
	Active site	168	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	200	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8UJ09 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4125678C30E7330B	FASTA	259	27,478
	10 20 30 40 50 60 MTMELQRPRE AAALTLSLLD LTNLREDCTP QQIATLCQRA HTEFGNTAAI CIWPRFVAQA 70 80 90 100 110 120 RAAFGKDHTI RIATVVNFPS GDLDVATVVA ETEAAIGDGA DEIDLVIPYR KFMAGDESAV 130 140 150 160 170 180 AEMIAAVRKA CAAPVLLKVI LETGELKDKA LIRRASEIAI AEGADFIKTS TGKVAVNATL 190 200 210 220 230 240 EAADIMLQAI RDSKKKVGFK PAGGIGTVED ATLYLRLAET IMAPNWAMPS TFRFGASGVL 250 DDVLNVLAGG EPAKAASGY

References

[1]	"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.
[2]	"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007869 Genomic DNA. Translation: AAK85953.2. Different initiation.
PIR	AF2592. H97374.
RefSeq	NP_353168.2. NC_003062.2.
3D structure databases
ProteinModelPortal	Q8UJ09.
SMR	Q8UJ09. Positions 12-250.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UJ09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1132170.
GenomeReviews	Gene locus Atu0132 in contig AE007869_GR.
KEGG	atu:Atu0132.
PATRIC	20809944. VBIAgrTum91616_0123.
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HBG636421.
OMA	FELVKQC.
PhylomeDB	Q8UJ09.
ProtClustDB	PRK05283.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU0132-MONOMER.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR023649. DeoC_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_AGRT5

Accession

Primary (citable) accession number: Q8UJ09

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program