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Q8UJ08 (TYPH_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:Atu0133
ORF Names:AGR_C_214
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_0000059048

Sequences

Sequence LengthMass (Da)Tools
Q8UJ08 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 8A0ED9CFFCE810A5

FASTA43845,638
        10         20         30         40         50         60 
MSLIPQEIIR RKRDGLSLAP QEIAAFIEAL SKDGISEGQA AAFAMAVFFR GMNRDEMVAL 

        70         80         90        100        110        120 
TLAMRDSGDV LSWRDIGRPV ADKHSTGGVG DNVSLMLAPI VAACGLAVPM ISGRGLGHTG 

       130        140        150        160        170        180 
GTLDKLEAIP GYDVMPDEAL FRRTVQSVGC AIIGQTGDLA PADKRLYAIR DVTATVDSIP 

       190        200        210        220        230        240 
LITASILSKK LAAGLETLVL DVKVGNGAFM QSLEDARILA RALVDVANGA GLPTTALITD 

       250        260        270        280        290        300 
MNQPLCDAAG NAVEIVNCLE FLAGGKAGTR LEKVVLSFAA EMLVQARKAA TLEEGEALAS 

       310        320        330        340        350        360 
AALSSGRAME IFARMVSVLG GPSDFIENPS RYLACAPIIL PVPAARSGWL ASCATRDLGM 

       370        380        390        400        410        420 
VVVELGGGRT KPSDTINPAV GISDILPLGV RVEKGEPIAV VHAASSEDAE RAVKRIEDCF 

       430 
GIADNAPEIA ASVLERIT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK85954.1.
PIRA97375.
AG2592.
RefSeqNP_353169.1. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UJ08.
SMRQ8UJ08. Positions 4-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu0133.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK85954; AAK85954; Atu0133.
GeneID1132171.
KEGGatu:Atu0133.
PATRIC20809946. VBIAgrTum91616_0124.

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMAHYRITED.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

BioCycAGRO:ATU0133-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_AGRT5
AccessionPrimary (citable) accession number: Q8UJ08
Secondary accession number(s): Q7D248
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways