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Q8UIS9

- PNCB_AGRT5

UniProt

Q8UIS9 - PNCB_AGRT5

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:Atu0213
    ORF Names:AGR_C_367
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_0000205817Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176299.Atu0213.

    Structurei

    Secondary structure

    1
    434
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 76
    Helixi29 – 4113
    Beta strandi46 – 549
    Turni61 – 633
    Helixi66 – 7611
    Helixi83 – 919
    Beta strandi94 – 963
    Helixi103 – 1108
    Beta strandi118 – 1214
    Beta strandi126 – 1305
    Helixi134 – 1374
    Helixi138 – 1403
    Helixi141 – 15717
    Helixi162 – 18322
    Beta strandi191 – 1933
    Turni196 – 1983
    Helixi202 – 21615
    Helixi217 – 2193
    Beta strandi220 – 2256
    Helixi226 – 2327
    Helixi243 – 2519
    Helixi255 – 27218
    Helixi275 – 2773
    Helixi287 – 2926
    Helixi296 – 3005
    Beta strandi301 – 3044
    Helixi311 – 32414
    Helixi329 – 3313
    Beta strandi332 – 3365
    Helixi342 – 35211
    Turni353 – 3553
    Beta strandi356 – 3627
    Helixi364 – 3674
    Beta strandi386 – 3938
    Helixi405 – 4073
    Helixi412 – 42211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YBEX-ray2.50A/B1-434[»]
    ProteinModelPortaliQ8UIS9.
    SMRiQ8UIS9. Positions 1-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8UIS9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284929.
    KOiK00763.
    OMAiSIVCKVI.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8UIS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKTDIATRV HNHTWKLDPI VRSLIDTDFY KLLMLQMIWK LYPEVDATFS    50
    LINRTKTVRL AEEIDEMELR EQLDHARTLR LSKKENIWLA GNTFYGRSQI 100
    FEPEFLSWLS SYQLPEYELF KRDGQYELNF HGRWMDTTLW EIPALSIINE 150
    LRSRSAMRSL GYFTLDVLYA RAKAKMWEKV ERLRELPGLR ISDFGTRRRH 200
    SFLWQRWCVE ALKEGIGPAF TGTSNVLLAM DSDLEAVGTN AHELPMVVAA 250
    LAQTNEELAA APYQVLKDWN RLYGGNLLIV LPDAFGTAAF LRNAPEWVAD 300
    WTGFRPDSAP PIEGGEKIIE WWRKMGRDPR TKMLIFSDGL DVDAIVDTYR 350
    HFEGRVRMSF GWGTNLTNDF AGCAPKTIAS LKPISIVCKV SDANGRPAVK 400
    LSDNPQKATG DPAEVERYLK FFGEEDHKEQ KVLV 434
    Length:434
    Mass (Da):49,902
    Last modified:July 11, 2002 - v2
    Checksum:iABC37DD605AE647F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86031.2.
    PIRiAF2602.
    F97384.
    RefSeqiNP_353246.2. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK86031; AAK86031; Atu0213.
    GeneIDi1132251.
    KEGGiatu:Atu0213.
    PATRICi20810107. VBIAgrTum91616_0204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86031.2 .
    PIRi AF2602.
    F97384.
    RefSeqi NP_353246.2. NC_003062.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YBE X-ray 2.50 A/B 1-434 [» ]
    ProteinModelPortali Q8UIS9.
    SMRi Q8UIS9. Positions 1-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu0213.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK86031 ; AAK86031 ; Atu0213 .
    GeneIDi 1132251.
    KEGGi atu:Atu0213.
    PATRICi 20810107. VBIAgrTum91616_0204.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284929.
    KOi K00763.
    OMAi SIVCKVI.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    EvolutionaryTracei Q8UIS9.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiPNCB_AGRT5
    AccessioniPrimary (citable) accession number: Q8UIS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3