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Q8UIS9

- PNCB_AGRT5

UniProt

Q8UIS9 - PNCB_AGRT5

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, Atu0213, AGR_C_367
Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:Atu0213
ORF Names:AGR_C_367
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_0000205817Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu0213.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 76
Helixi29 – 4113
Beta strandi46 – 549
Turni61 – 633
Helixi66 – 7611
Helixi83 – 919
Beta strandi94 – 963
Helixi103 – 1108
Beta strandi118 – 1214
Beta strandi126 – 1305
Helixi134 – 1374
Helixi138 – 1403
Helixi141 – 15717
Helixi162 – 18322
Beta strandi191 – 1933
Turni196 – 1983
Helixi202 – 21615
Helixi217 – 2193
Beta strandi220 – 2256
Helixi226 – 2327
Helixi243 – 2519
Helixi255 – 27218
Helixi275 – 2773
Helixi287 – 2926
Helixi296 – 3005
Beta strandi301 – 3044
Helixi311 – 32414
Helixi329 – 3313
Beta strandi332 – 3365
Helixi342 – 35211
Turni353 – 3553
Beta strandi356 – 3627
Helixi364 – 3674
Beta strandi386 – 3938
Helixi405 – 4073
Helixi412 – 42211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YBEX-ray2.50A/B1-434[»]
ProteinModelPortaliQ8UIS9.
SMRiQ8UIS9. Positions 1-426.

Miscellaneous databases

EvolutionaryTraceiQ8UIS9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UIS9-1 [UniParc]FASTAAdd to Basket

« Hide

MTKTDIATRV HNHTWKLDPI VRSLIDTDFY KLLMLQMIWK LYPEVDATFS    50
LINRTKTVRL AEEIDEMELR EQLDHARTLR LSKKENIWLA GNTFYGRSQI 100
FEPEFLSWLS SYQLPEYELF KRDGQYELNF HGRWMDTTLW EIPALSIINE 150
LRSRSAMRSL GYFTLDVLYA RAKAKMWEKV ERLRELPGLR ISDFGTRRRH 200
SFLWQRWCVE ALKEGIGPAF TGTSNVLLAM DSDLEAVGTN AHELPMVVAA 250
LAQTNEELAA APYQVLKDWN RLYGGNLLIV LPDAFGTAAF LRNAPEWVAD 300
WTGFRPDSAP PIEGGEKIIE WWRKMGRDPR TKMLIFSDGL DVDAIVDTYR 350
HFEGRVRMSF GWGTNLTNDF AGCAPKTIAS LKPISIVCKV SDANGRPAVK 400
LSDNPQKATG DPAEVERYLK FFGEEDHKEQ KVLV 434
Length:434
Mass (Da):49,902
Last modified:July 11, 2002 - v2
Checksum:iABC37DD605AE647F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK86031.2.
PIRiAF2602.
F97384.
RefSeqiNP_353246.2. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK86031; AAK86031; Atu0213.
GeneIDi1132251.
KEGGiatu:Atu0213.
PATRICi20810107. VBIAgrTum91616_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK86031.2 .
PIRi AF2602.
F97384.
RefSeqi NP_353246.2. NC_003062.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YBE X-ray 2.50 A/B 1-434 [» ]
ProteinModelPortali Q8UIS9.
SMRi Q8UIS9. Positions 1-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176299.Atu0213.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK86031 ; AAK86031 ; Atu0213 .
GeneIDi 1132251.
KEGGi atu:Atu0213.
PATRICi 20810107. VBIAgrTum91616_0204.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

EvolutionaryTracei Q8UIS9.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiPNCB_AGRT5
AccessioniPrimary (citable) accession number: Q8UIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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