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Q8UID4

- TRMB_AGRT5

UniProt

Q8UID4 - TRMB_AGRT5

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Atu0363, AGR_C_634
Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631S-adenosyl-L-methionine By similarity
Binding sitei88 – 881S-adenosyl-L-methionine By similarity
Binding sitei115 – 1151S-adenosyl-L-methionine By similarity
Active sitei137 – 1371 By similarity
Binding sitei137 – 1371S-adenosyl-L-methionine By similarity
Binding sitei141 – 1411Substrate By similarity
Binding sitei173 – 1731Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciAGRO:ATU0363-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:Atu0363
    ORF Names:AGR_C_634
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171284Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176299.Atu0363.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8UID4.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 2144Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiRAFYGRR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8UID4-1 [UniParc]FASTAAdd to Basket

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    MTEERRSRAT EAFFGRRKGK PLRNQQVDTI ENLLPLLKID LESVPPQNLV    50
    ALFPADVRSI RLEIGFGGGE HLAHRAVENP ETGFIGVEPF VNSMAKLLAT 100
    VRERELMNIR LYDDDATQLL DWLPEGSIDH IDLLYPDPWP KKKHWKRRFV 150
    SDVNLARFHR VLKPGGKFCF ASDIDTYVNW TLQHCARHGG FEWTATSADD 200
    WRTPYANWPG TRYENKAKRE GRSSAYLTFI RR 232
    Length:232
    Mass (Da):26,864
    Last modified:June 1, 2002 - v1
    Checksum:i7F8A29F4E1F00423
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86180.1.
    PIRiAC2621.
    C97403.
    RefSeqiNP_353395.1. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK86180; AAK86180; Atu0363.
    GeneIDi1132401.
    KEGGiatu:Atu0363.
    PATRICi20810409. VBIAgrTum91616_0354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86180.1 .
    PIRi AC2621.
    C97403.
    RefSeqi NP_353395.1. NC_003062.2.

    3D structure databases

    ProteinModelPortali Q8UID4.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu0363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK86180 ; AAK86180 ; Atu0363 .
    GeneIDi 1132401.
    KEGGi atu:Atu0363.
    PATRICi 20810409. VBIAgrTum91616_0354.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi RAFYGRR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci AGRO:ATU0363-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiTRMB_AGRT5
    AccessioniPrimary (citable) accession number: Q8UID4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 1, 2002
    Last modified: June 11, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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