Reviewed,
UniProtKB/Swiss-Prot Q8UI99 (PYRC_AGRT5)
Last modified
November 25, 2008.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydroorotase Short name=DHOase EC=3.5.2.3 | ||||||
| Gene names |
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| Organism | Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 176299 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium |
Protein attributes
| Sequence length | 345 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219 |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6. HAMAP MF_00219 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the DHOase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 345 | 345 | Dihydroorotase HAMAP MF_00219 | PRO_0000147202 | |||||
Sites | |||||||||
| Metal binding | 13 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 15 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 99 | 1 | Zinc 1; via carbamate group By similarity | ||||||
| Metal binding | 99 | 1 | Zinc 2; via carbamate group By similarity | ||||||
| Metal binding | 136 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 174 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 247 | 1 | Zinc 1 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 99 | 1 | N6-carboxylysine By similarity | ||||||
Sequences
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References
| [1] | "The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. Nester E.W.Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. Slater S.Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AE007869 Genomic DNA. Translation: AAK86214.2. | |
| PIR | AF2625. E97407. |
| RefSeq | NP_353429.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1J79 based on UniProtKB P05020. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1132437. |
| GenomeReviews | Gene locus Atu0399 in contig AE007869_GR. |
| KEGG | atc:AGR_C_703. atu:Atu0399. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8UI99. |
Family and domain databases | |
| HAMAP | MF_00219. [Tree] |
| InterPro | IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view] |
| Pfam | PF01979. Amidohydro_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF001237. DHOdimr. 1 hit. |
| TIGRFAMs | TIGR00856. pyrC_dimer. 1 hit. |
| PROSITE | PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRC_AGRT5 | ||||||||
| Accession | Primary (citable) accession number: Q8UI99 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


