Reviewed, UniProtKB/Swiss-Prot Q8UI94 (G6PI_AGRT5)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Atu0404
ORF Names:	AGR_C_711

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 541	541	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180581
Sites
	Active site	346	1	Proton donor By similarity
	Active site	377	1	By similarity
	Active site	506	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8UI94-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4077F32868CFA3D1	FASTA	541	58,709
	10 20 30 40 50 60 MQATIEKLKA TASSTAATDL RAAFAADDQR FSRFSVKFDD LLMDYSKCAV NEEIVTLLEQ 70 80 90 100 110 120 LAREGGVEAK REEMFSGKAI NFTEDRAVLH TALRNRSNTP VLVDDKDVMP DVNGVLAAMG 130 140 150 160 170 180 KFADAIRSGS LKGATGKKIT DVVNIGIGGS DLGPVMATLA LAPFHDGPRA HFVSNIDGAH 190 200 210 220 230 240 IADTLKLLDP ETSLFIIASK TFTTIETMTN AATARRFIAE KLGEGAVKHH FAAVSTALDK 250 260 270 280 290 300 VAAFGIESDR IFGFWDWVGG RYSIWSAIGL PLMIAIGPDN FGKFLDGAHA MDRHFREAPI 310 320 330 340 350 360 RENLPMLLGL IGFYNRNVLD YPTRAILPYD QRLSRFPAYL QQLDMESNGK GVTIDGTPVE 370 380 390 400 410 420 GQSGPVVWGE PGTNGQHAFY QLIHQGTSVI PAEFMIAANG FEPELRHQHQ LLIANCLAQS 430 440 450 460 470 480 EALMKGRTLA EAKAQLTSKG MEDSQADFIA PHRVFTGNRP SITFVYDKLT PFALGRLIAL 490 500 510 520 530 540 YEHRVFVEGV LFRINSFDQW GVELGKELAT GLLPVVEGKE SAAGHDSSTQ GLVKALAGLA G

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE007869 Genomic DNA. Translation: AAK86219.1.
PIR	AC2626. B97408.
RefSeq	NP_353434.1.
3D structure databases
HSSP	HSSP built from PDB template 1HM5 based on UniProtKB Q9N1E2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UI94.
Genome annotation databases
GeneID	1132442.
GenomeReviews	Gene locus Atu0404 in contig AE007869_GR.
KEGG	atc:AGR_C_711. atu:Atu0404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8UI94.
OMA	GPKIVSQ.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_AGRT5

Accession

Primary (citable) accession number: Q8UI94

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)