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Q8UH56

- BETB_AGRT5

UniProt

Q8UH56 - BETB_AGRT5

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi32 – 321Potassium 1UniRule annotation
    Metal bindingi33 – 331Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi99 – 991Potassium 1UniRule annotation
    Active sitei168 – 1681Charge relay systemUniRule annotation
    Metal bindingi250 – 2501Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei256 – 2561Proton acceptorUniRule annotation
    Binding sitei290 – 2901NAD/NADPUniRule annotation
    Binding sitei390 – 3901NAD/NADPUniRule annotation
    Metal bindingi460 – 4601Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi463 – 4631Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei467 – 4671Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi156 – 1594NAD/NADPUniRule annotation
    Nucleotide bindingi182 – 1854NAD/NADPUniRule annotation
    Nucleotide bindingi234 – 2396NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciAGRO:ATU0829-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:Atu0829
    ORF Names:AGR_C_1515
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_0000056535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei290 – 2901Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.1 Publication

    Protein-protein interaction databases

    STRINGi176299.Atu0829.

    Structurei

    Secondary structure

    1
    493
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 176
    Beta strandi20 – 223
    Beta strandi29 – 335
    Turni35 – 373
    Beta strandi40 – 456
    Helixi49 – 6820
    Helixi71 – 8717
    Helixi89 – 10012
    Helixi104 – 1107
    Helixi112 – 12918
    Beta strandi134 – 1363
    Beta strandi138 – 14811
    Beta strandi150 – 1556
    Beta strandi158 – 1603
    Helixi161 – 17414
    Beta strandi178 – 1825
    Helixi190 – 20011
    Beta strandi207 – 2104
    Helixi217 – 2226
    Beta strandi227 – 2348
    Helixi236 – 24813
    Beta strandi252 – 2565
    Beta strandi261 – 2655
    Helixi271 – 28212
    Helixi287 – 2904
    Beta strandi294 – 2996
    Helixi300 – 3023
    Helixi303 – 31614
    Helixi335 – 35117
    Beta strandi354 – 3574
    Beta strandi367 – 3704
    Beta strandi375 – 3806
    Helixi385 – 3884
    Beta strandi392 – 40110
    Helixi404 – 4129
    Beta strandi414 – 42310
    Helixi427 – 43610
    Beta strandi440 – 4467
    Helixi470 – 4756
    Beta strandi476 – 4849

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3R31X-ray2.15A/B1-493[»]
    ProteinModelPortaliQ8UH56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiCEHQLVA.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8UH56-1 [UniParc]FASTAAdd to Basket

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    MTIATPLKAQ PKASHFIDGD YVEDNTGTPF ESIFPATGEM IAKLHAATPA    50
    IVERAIASAK RAQKEWAAMS PMARGRILKR AADIMRERND ALSTLETLDT 100
    GKPIQETIVA DPTSGADAFE FFGGIAPSAL NGDYIPLGGD FAYTKRVPLG 150
    VCVGIGAWNY PQQIACWKAA PALVAGNAMV FKPSENTPLG ALKIAEILIE 200
    AGLPKGLFNV IQGDRDTGPL LVNHPDVAKV SLTGSVPTGR KVAAAAAGHL 250
    KHVTMELGGK SPMIVFDDAD IESAVGGAML GNFYSSGQVC SNGTRVFVQK 300
    KAKARFLENL KRRTEAMILG DPLDYATHLG PLVSKAQQEK VLSYIEKGKA 350
    EGATLITGGG IPNNVAGEGA YVQPTVFADV TDDMTIAREE IFGPVMCVLD 400
    FDDEDEVLAR ANATEFGLAG GVFTADLARA HRVVDGLEAG TLWINTYNLC 450
    PVEIPFGGSK QSGFGRENSA AALEHYSELK TVYVSTGKVD APY 493
    Length:493
    Mass (Da):52,204
    Last modified:June 1, 2002 - v1
    Checksum:i7636ADEEB5327833
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86635.1.
    PIRiAE2678.
    B97460.
    RefSeqiNP_353850.1. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK86635; AAK86635; Atu0829.
    GeneIDi1132867.
    KEGGiatu:Atu0829.
    PATRICi20811367. VBIAgrTum91616_0825.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK86635.1 .
    PIRi AE2678.
    B97460.
    RefSeqi NP_353850.1. NC_003062.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3R31 X-ray 2.15 A/B 1-493 [» ]
    ProteinModelPortali Q8UH56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu0829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK86635 ; AAK86635 ; Atu0829 .
    GeneIDi 1132867.
    KEGGi atu:Atu0829.
    PATRICi 20811367. VBIAgrTum91616_0825.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi CEHQLVA.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci AGRO:ATU0829-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    3. "Crystal structure of betaine aldehyde dehydrogenase from Agrobacterium tumefaciens."
      New York structural genomics research consortium (NYSGRC)
      Submitted (MAR-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiBETB_AGRT5
    AccessioniPrimary (citable) accession number: Q8UH56
    Secondary accession number(s): Q7D0K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3