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Q8UH56

- BETB_AGRT5

UniProt

Q8UH56 - BETB_AGRT5

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, Atu0829, AGR_C_1515
Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi32 – 321Potassium 1 By similarity
Metal bindingi33 – 331Potassium 1; via carbonyl oxygen By similarity
Metal bindingi99 – 991Potassium 1 By similarity
Active sitei168 – 1681Charge relay system By similarity
Metal bindingi250 – 2501Potassium 2; via carbonyl oxygen By similarity
Active sitei256 – 2561Proton acceptor By similarity
Binding sitei290 – 2901NAD/NADP By similarity
Binding sitei390 – 3901NAD/NADP By similarity
Metal bindingi460 – 4601Potassium 2; via carbonyl oxygen By similarity
Metal bindingi463 – 4631Potassium 2; via carbonyl oxygen By similarity
Active sitei467 – 4671Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi156 – 1594NAD/NADP By similarity
Nucleotide bindingi182 – 1854NAD/NADP By similarity
Nucleotide bindingi234 – 2396NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciAGRO:ATU0829-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Atu0829
ORF Names:AGR_C_1515
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_0000056535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei290 – 2901Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers Inferred.1 Publication

Protein-protein interaction databases

STRINGi176299.Atu0829.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 176
Beta strandi20 – 223
Beta strandi29 – 335
Turni35 – 373
Beta strandi40 – 456
Helixi49 – 6820
Helixi71 – 8717
Helixi89 – 10012
Helixi104 – 1107
Helixi112 – 12918
Beta strandi134 – 1363
Beta strandi138 – 14811
Beta strandi150 – 1556
Beta strandi158 – 1603
Helixi161 – 17414
Beta strandi178 – 1825
Helixi190 – 20011
Beta strandi207 – 2104
Helixi217 – 2226
Beta strandi227 – 2348
Helixi236 – 24813
Beta strandi252 – 2565
Beta strandi261 – 2655
Helixi271 – 28212
Helixi287 – 2904
Beta strandi294 – 2996
Helixi300 – 3023
Helixi303 – 31614
Helixi335 – 35117
Beta strandi354 – 3574
Beta strandi367 – 3704
Beta strandi375 – 3806
Helixi385 – 3884
Beta strandi392 – 40110
Helixi404 – 4129
Beta strandi414 – 42310
Helixi427 – 43610
Beta strandi440 – 4467
Helixi470 – 4756
Beta strandi476 – 4849

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R31X-ray2.15A/B1-493[»]
ProteinModelPortaliQ8UH56.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCEHQLVA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UH56-1 [UniParc]FASTAAdd to Basket

« Hide

MTIATPLKAQ PKASHFIDGD YVEDNTGTPF ESIFPATGEM IAKLHAATPA    50
IVERAIASAK RAQKEWAAMS PMARGRILKR AADIMRERND ALSTLETLDT 100
GKPIQETIVA DPTSGADAFE FFGGIAPSAL NGDYIPLGGD FAYTKRVPLG 150
VCVGIGAWNY PQQIACWKAA PALVAGNAMV FKPSENTPLG ALKIAEILIE 200
AGLPKGLFNV IQGDRDTGPL LVNHPDVAKV SLTGSVPTGR KVAAAAAGHL 250
KHVTMELGGK SPMIVFDDAD IESAVGGAML GNFYSSGQVC SNGTRVFVQK 300
KAKARFLENL KRRTEAMILG DPLDYATHLG PLVSKAQQEK VLSYIEKGKA 350
EGATLITGGG IPNNVAGEGA YVQPTVFADV TDDMTIAREE IFGPVMCVLD 400
FDDEDEVLAR ANATEFGLAG GVFTADLARA HRVVDGLEAG TLWINTYNLC 450
PVEIPFGGSK QSGFGRENSA AALEHYSELK TVYVSTGKVD APY 493
Length:493
Mass (Da):52,204
Last modified:June 1, 2002 - v1
Checksum:i7636ADEEB5327833
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK86635.1.
PIRiAE2678.
B97460.
RefSeqiNP_353850.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK86635; AAK86635; Atu0829.
GeneIDi1132867.
KEGGiatu:Atu0829.
PATRICi20811367. VBIAgrTum91616_0825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK86635.1 .
PIRi AE2678.
B97460.
RefSeqi NP_353850.1. NC_003062.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3R31 X-ray 2.15 A/B 1-493 [» ]
ProteinModelPortali Q8UH56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176299.Atu0829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK86635 ; AAK86635 ; Atu0829 .
GeneIDi 1132867.
KEGGi atu:Atu0829.
PATRICi 20811367. VBIAgrTum91616_0825.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CEHQLVA.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci AGRO:ATU0829-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  3. "Crystal structure of betaine aldehyde dehydrogenase from Agrobacterium tumefaciens."
    New York structural genomics research consortium (NYSGRC)
    Submitted (MAR-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiBETB_AGRT5
AccessioniPrimary (citable) accession number: Q8UH56
Secondary accession number(s): Q7D0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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