Reviewed, UniProtKB/Swiss-Prot Q8UH56 (BETB_AGRT5)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Atu0829
ORF Names:	AGR_C_1515

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056535
Regions
	Nucleotide binding	234 – 239	6	NAD By similarity
Sites
	Active site	256	1	By similarity
	Active site	290	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8UH56-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 7636ADEEB5327833	FASTA	493	52,204
	10 20 30 40 50 60 MTIATPLKAQ PKASHFIDGD YVEDNTGTPF ESIFPATGEM IAKLHAATPA IVERAIASAK 70 80 90 100 110 120 RAQKEWAAMS PMARGRILKR AADIMRERND ALSTLETLDT GKPIQETIVA DPTSGADAFE 130 140 150 160 170 180 FFGGIAPSAL NGDYIPLGGD FAYTKRVPLG VCVGIGAWNY PQQIACWKAA PALVAGNAMV 190 200 210 220 230 240 FKPSENTPLG ALKIAEILIE AGLPKGLFNV IQGDRDTGPL LVNHPDVAKV SLTGSVPTGR 250 260 270 280 290 300 KVAAAAAGHL KHVTMELGGK SPMIVFDDAD IESAVGGAML GNFYSSGQVC SNGTRVFVQK 310 320 330 340 350 360 KAKARFLENL KRRTEAMILG DPLDYATHLG PLVSKAQQEK VLSYIEKGKA EGATLITGGG 370 380 390 400 410 420 IPNNVAGEGA YVQPTVFADV TDDMTIAREE IFGPVMCVLD FDDEDEVLAR ANATEFGLAG 430 440 450 460 470 480 GVFTADLARA HRVVDGLEAG TLWINTYNLC PVEIPFGGSK QSGFGRENSA AALEHYSELK 490 TVYVSTGKVD APY

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE007869 Genomic DNA. Translation: AAK86635.1.
PIR	AE2678. B97460.
RefSeq	NP_353850.1.
3D structure databases
HSSP	HSSP built from PDB template 1A4S based on UniProtKB P56533.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UH56.
Genome annotation databases
GeneID	1132867.
GenomeReviews	Gene locus Atu0829 in contig AE007869_GR.
KEGG	atc:AGR_C_1515. atu:Atu0829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8UH56.
OMA	VFKPSEN.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_AGRT5

Accession

Primary (citable) accession number: Q8UH56
Secondary accession number(s): Q7D0K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)