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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 33FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciAGRO:ATU0830-MONOMER
UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Atu0830
ORF Names:AGR_C_1517
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055831 – 549Oxygen-dependent choline dehydrogenaseAdd BLAST549

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu0830

Structurei

3D structure databases

ProteinModelPortaliQ8UH55
SMRiQ8UH55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UH55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADYVIVGS GSAGSAIAYR LSEDGRYSVI VIEAGGSDFG PFIQMPAALA
60 70 80 90 100
WPMSMKRYNW GYLSEPEPNL DNRRITAPRG KVIGGSSSIN GLVYVRGHAE
110 120 130 140 150
DFNRWEELGA QGWAYADVLP YFKRMEHSHG GEEGWRGTDG PLHVQRGPVS
160 170 180 190 200
NPLFHAFIQA GAQAGFELTD DYNGSKQEGF GLMEQTIHNG RRWSAANAYL
210 220 230 240 250
KPALKRGNVT LVNGFARKVI IENGRAVGVE IERRGRVETV KANREVIVSA
260 270 280 290 300
SSFNSPKLLM LSGIGPAAHL KDMGIEVKAD RPGVGANLQD HMEFYFQQVS
310 320 330 340 350
TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP
360 370 380 390 400
DIQYHFLPVA ISYDGKAAAK SHGFQAHVGY NLSKSRGNVT LRSADPHDDP
410 420 430 440 450
VIRFNYMSHP EDWEKFRHCV RLTREIFGQK AFDDFRGPEI QPGENIETDE
460 470 480 490 500
QIDAFLREHL ESAYHPCGTC RMGDRNDPMA VVDPECRVIG VEGLRVADSS
510 520 530 540
IFPHVTYGNL NGPSIMTGEK AADHILGKTP LPRSNQEPWV NPRAAVSDR
Length:549
Mass (Da):60,627
Last modified:February 16, 2004 - v2
Checksum:i6AFD59ED94037C16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK86636.2
PIRiAF2678
C97460
RefSeqiNP_353851.2, NC_003062.2
WP_010971180.1, NC_003062.2

Genome annotation databases

EnsemblBacteriaiAAK86636; AAK86636; Atu0830
GeneIDi1132868
KEGGiatu:Atu0830
PATRICifig|176299.10.peg.826

Similar proteinsi

Entry informationi

Entry nameiBETA_AGRFC
AccessioniPrimary (citable) accession number: Q8UH55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: March 28, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health