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Q8UH55 (BETA_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:Atu0830
ORF Names:AGR_C_1517
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205583

Regions

Nucleotide binding4 – 3330FAD By similarity

Sites

Active site4651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UH55 [UniParc].

Last modified February 16, 2004. Version 2.
Checksum: 6AFD59ED94037C16

FASTA54960,627
        10         20         30         40         50         60 
MQADYVIVGS GSAGSAIAYR LSEDGRYSVI VIEAGGSDFG PFIQMPAALA WPMSMKRYNW 

        70         80         90        100        110        120 
GYLSEPEPNL DNRRITAPRG KVIGGSSSIN GLVYVRGHAE DFNRWEELGA QGWAYADVLP 

       130        140        150        160        170        180 
YFKRMEHSHG GEEGWRGTDG PLHVQRGPVS NPLFHAFIQA GAQAGFELTD DYNGSKQEGF 

       190        200        210        220        230        240 
GLMEQTIHNG RRWSAANAYL KPALKRGNVT LVNGFARKVI IENGRAVGVE IERRGRVETV 

       250        260        270        280        290        300 
KANREVIVSA SSFNSPKLLM LSGIGPAAHL KDMGIEVKAD RPGVGANLQD HMEFYFQQVS 

       310        320        330        340        350        360 
TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP DIQYHFLPVA 

       370        380        390        400        410        420 
ISYDGKAAAK SHGFQAHVGY NLSKSRGNVT LRSADPHDDP VIRFNYMSHP EDWEKFRHCV 

       430        440        450        460        470        480 
RLTREIFGQK AFDDFRGPEI QPGENIETDE QIDAFLREHL ESAYHPCGTC RMGDRNDPMA 

       490        500        510        520        530        540 
VVDPECRVIG VEGLRVADSS IFPHVTYGNL NGPSIMTGEK AADHILGKTP LPRSNQEPWV 


NPRAAVSDR 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK86636.2.
PIRAF2678.
C97460.
RefSeqNP_353851.2. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UH55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu0830.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK86636; AAK86636; Atu0830.
GeneID1132868.
KEGGatu:Atu0830.
PATRIC20811369. VBIAgrTum91616_0826.

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMALTDDYNG.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycAGRO:ATU0830-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_AGRT5
AccessionPrimary (citable) accession number: Q8UH55
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: May 14, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways