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Protein

Trans-aconitate 2-methyltransferase

Gene

tam

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAGRO:ATU0870-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-aconitate 2-methyltransferaseUniRule annotation (EC:2.1.1.144UniRule annotation)
Gene namesi
Name:tamUniRule annotation
Ordered Locus Names:Atu0870
ORF Names:AGR_C_1589
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002180761 – 256Trans-aconitate 2-methyltransferaseAdd BLAST256

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi14 – 16Combined sources3
Helixi17 – 23Combined sources7
Beta strandi32 – 37Combined sources6
Turni40 – 42Combined sources3
Helixi43 – 52Combined sources10
Beta strandi56 – 62Combined sources7
Helixi64 – 73Combined sources10
Beta strandi77 – 81Combined sources5
Turni84 – 86Combined sources3
Beta strandi93 – 100Combined sources8
Helixi102 – 104Combined sources3
Helixi108 – 115Combined sources8
Helixi116 – 118Combined sources3
Beta strandi119 – 130Combined sources12
Helixi136 – 147Combined sources12
Helixi151 – 153Combined sources3
Helixi167 – 174Combined sources8
Helixi175 – 177Combined sources3
Beta strandi178 – 193Combined sources16
Helixi195 – 202Combined sources8
Turni203 – 208Combined sources6
Helixi209 – 212Combined sources4
Helixi216 – 218Combined sources3
Helixi219 – 233Combined sources15
Beta strandi242 – 255Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P35X-ray1.95A/B1-256[»]
ProteinModelPortaliQ8UH15.
SMRiQ8UH15.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8UH15.

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. Tam family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R6G. Bacteria.
COG4106. LUCA.
HOGENOMiHOG000125295.
KOiK00598.
OMAiETTYLHV.

Family and domain databases

Gene3Di1.10.150.290. 2 hits.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UH15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSAQQYLK FEDERTRPAR DLLAQVPLER VLNGYDLGCG PGNSTELLTD
60 70 80 90 100
RYGVNVITGI DSDDDMLEKA ADRLPNTNFG KADLATWKPA QKADLLYANA
110 120 130 140 150
VFQWVPDHLA VLSQLMDQLE SGGVLAVQMP DNLQEPTHIA MHETADGGPW
160 170 180 190 200
KDAFSGGGLR RKPLPPPSDY FNALSPKSSR VDVWHTVYNH PMKDADSIVE
210 220 230 240 250
WVKGTGLRPY LAAAGEENRE AFLADYTRRI AAAYPPMADG RLLLRFPRLF

VVAVKK
Length:256
Mass (Da):28,437
Last modified:June 6, 2002 - v1
Checksum:i4F35AA046D0596B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK86677.1.
PIRiAF2683.
D97465.
RefSeqiNP_353892.1. NC_003062.2.
WP_006312207.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK86677; AAK86677; Atu0870.
GeneIDi1132908.
KEGGiatu:Atu0870.
PATRICi20811453. VBIAgrTum91616_0868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK86677.1.
PIRiAF2683.
D97465.
RefSeqiNP_353892.1. NC_003062.2.
WP_006312207.1. NC_003062.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P35X-ray1.95A/B1-256[»]
ProteinModelPortaliQ8UH15.
SMRiQ8UH15.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK86677; AAK86677; Atu0870.
GeneIDi1132908.
KEGGiatu:Atu0870.
PATRICi20811453. VBIAgrTum91616_0868.

Phylogenomic databases

eggNOGiENOG4107R6G. Bacteria.
COG4106. LUCA.
HOGENOMiHOG000125295.
KOiK00598.
OMAiETTYLHV.

Enzyme and pathway databases

BioCyciAGRO:ATU0870-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8UH15.

Family and domain databases

Gene3Di1.10.150.290. 2 hits.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAM_AGRFC
AccessioniPrimary (citable) accession number: Q8UH15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.