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Q8UGK2 (RNC_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:Atu1035
ORF Names:AGR_C_1906
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180369

Regions

Domain12 – 137126RNase III
Domain162 – 23170DRBM

Sites

Active site541 Potential
Active site1261 By similarity
Metal binding501Magnesium By similarity
Metal binding1231Magnesium By similarity
Metal binding1261Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UGK2 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: 4D8AA238CC783977

FASTA23926,255
        10         20         30         40         50         60 
MSKTKPLSAD EISRLEALIG YEFKEKARLD RALTHASARS AAAGNYERLE FLGDRVLGLC 

        70         80         90        100        110        120 
VAELLFSTFR NASEGELSVR LNQLVSAESC AAIGDEMGLH NFIRTGSDVK KLTGKAMLNV 

       130        140        150        160        170        180 
RADVVESLIA TLYLDGGLEA SRKFILKYWQ GRATSVDAGR RDAKTELQEW AHARFAATPA 

       190        200        210        220        230 
YRVDDRSGPD HDPSFTVTVE IPGVKPETGV ERSKRAAEQV AATRLLEREG VWRKSPTGN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK86843.2.
PIRAB2704.
B97486.
RefSeqNP_354058.2. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UGK2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu1035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK86843; AAK86843; Atu1035.
GeneID1133073.
KEGGatu:Atu1035.
PATRIC20811813. VBIAgrTum91616_1047.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246809.
KOK03685.
OMALTHKSCK.
OrthoDBEOG6T1WVS.
ProtClustDBPRK12371.

Enzyme and pathway databases

BioCycAGRO:ATU1035-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_AGRT5
AccessionPrimary (citable) accession number: Q8UGK2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families