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Protein

Ribonuclease 3

Gene

rnc

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50MagnesiumUniRule annotation1
Active sitei54UniRule annotation1
Metal bindingi123MagnesiumUniRule annotation1
Active sitei126UniRule annotation1
Metal bindingi126MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciAGRO:ATU1035-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:Atu1035
ORF Names:AGR_C_1906
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803691 – 239Ribonuclease 3Add BLAST239

Proteomic databases

PRIDEiQ8UGK2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1035

Structurei

3D structure databases

ProteinModelPortaliQ8UGK2
SMRiQ8UGK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 137RNase IIIUniRule annotationAdd BLAST126
Domaini162 – 231DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UGK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTKPLSAD EISRLEALIG YEFKEKARLD RALTHASARS AAAGNYERLE
60 70 80 90 100
FLGDRVLGLC VAELLFSTFR NASEGELSVR LNQLVSAESC AAIGDEMGLH
110 120 130 140 150
NFIRTGSDVK KLTGKAMLNV RADVVESLIA TLYLDGGLEA SRKFILKYWQ
160 170 180 190 200
GRATSVDAGR RDAKTELQEW AHARFAATPA YRVDDRSGPD HDPSFTVTVE
210 220 230
IPGVKPETGV ERSKRAAEQV AATRLLEREG VWRKSPTGN
Length:239
Mass (Da):26,255
Last modified:August 30, 2002 - v2
Checksum:i4D8AA238CC783977
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK86843.2
PIRiAB2704
B97486
RefSeqiNP_354058.2, NC_003062.2
WP_010971346.1, NC_003062.2

Genome annotation databases

EnsemblBacteriaiAAK86843; AAK86843; Atu1035
GeneIDi1133073
KEGGiatu:Atu1035
PATRICifig|176299.10.peg.1047

Similar proteinsi

Entry informationi

Entry nameiRNC_AGRFC
AccessioniPrimary (citable) accession number: Q8UGK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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