Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8UGD4 (PDXA_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:Atu1104
ORF Names:AGR_C_2043
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3403404-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_0000188794

Sites

Metal binding1741Divalent metal cation; shared with dimeric partner By similarity
Metal binding2191Divalent metal cation; shared with dimeric partner By similarity
Metal binding2741Divalent metal cation; shared with dimeric partner By similarity
Binding site1391Substrate By similarity
Binding site1401Substrate By similarity
Binding site2821Substrate By similarity
Binding site2911Substrate By similarity
Binding site3001Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UGD4 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: BC94AF33699750E4

FASTA34035,727
        10         20         30         40         50         60 
MTHASLPLAL TQGDPAGIGP DIAINAWAKR RENGVPPFIF IGDPDVVASR AALIGVPVNI 

        70         80         90        100        110        120 
ETCDPESAVS LFERAFPILP LPVGFDVQAG QPHVGAAHAT IKAIEMAVSL TVEGRAAAVV 

       130        140        150        160        170        180 
TNPIAKSVLY EAGFGFPGHT EFLADLALRQ TGKPVTPVMM IAGPKVRVVP VTIHIPIKDV 

       190        200        210        220        230        240 
PTALTEELIV TTCRIIDTDL REKFGIAAPR LAVAGLNPHA GEDGALGTED RDVVHPATIR 

       250        260        270        280        290        300 
LRKDGIDAFG PLPADTMFHD AARKRYDVAV CMYHDQALIP AKALGFDDSV NVTLGLPFIR 

       310        320        330        340 
TSPDHGTAFG IAGQGIASET SLVAALKMAA EIYARSRVGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK86910.2.
PIRAG2712.
E97494.
RefSeqNP_354125.2. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UGD4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu1104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK86910; AAK86910; Atu1104.
GeneID1133142.
KEGGatu:Atu1104.
PATRIC20811959. VBIAgrTum91616_1120.

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221592.
KOK00097.
OMADTLFQDK.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK05312.

Enzyme and pathway databases

BioCycAGRO:ATU1104-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_AGRT5
AccessionPrimary (citable) accession number: Q8UGD4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: February 19, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways