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Q8UG98

- PUR5_AGRT5

UniProt

Q8UG98 - PUR5_AGRT5

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Atu1141, AGR_C_2111
Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAGRO:ATU1141-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Atu1141
ORF Names:AGR_C_2111
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000148193Add
BLAST

Proteomic databases

PRIDEiQ8UG98.

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu1141.

Structurei

3D structure databases

ProteinModelPortaliQ8UG98.
SMRiQ8UG98. Positions 8-345.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UG98-1 [UniParc]FASTAAdd to Basket

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MSQSGKNGLT YSDAGVDIDA GNLMVEKIKP AVRSTRRPGA DGEIGGFGGL    50
FDLKAAGFTD PVLVAANDGV GTKLKIAIDA DYHDTVGIDL VAMCVNDLVV 100
QGAEPLFFLD YFATGKLDPD QGAAIVSGIA AGCRESGCAL IGGETAEMPG 150
MYSDGDYDLA GFAVGAAERG QLLPAGDIAE GDVILGLSSS GVHSNGFSLV 200
RKIVSLSGLE WSAPAPFADG KKLGEALLTP TRIYVKPLLK AIRETGALKA 250
LAHITGGGFP ENIPRVLPKH LAAEIDLAAI KVPAVFSWLA KTGGVEAHEM 300
LRTFNCGVGM IVVVSAENAT KVTEALTAEG ETVFPLGRMV AREDGAHGTI 350
YKGTLGL 357
Length:357
Mass (Da):36,799
Last modified:November 28, 2003 - v2
Checksum:iC57C009287B9B9CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK86944.2.
PIRiAD2717.
G97498.
RefSeqiNP_354159.2. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK86944; AAK86944; Atu1141.
GeneIDi1133179.
KEGGiatu:Atu1141.
PATRICi20812035. VBIAgrTum91616_1158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK86944.2 .
PIRi AD2717.
G97498.
RefSeqi NP_354159.2. NC_003062.2.

3D structure databases

ProteinModelPortali Q8UG98.
SMRi Q8UG98. Positions 8-345.
ModBasei Search...

Protein-protein interaction databases

STRINGi 176299.Atu1141.

Proteomic databases

PRIDEi Q8UG98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK86944 ; AAK86944 ; Atu1141 .
GeneIDi 1133179.
KEGGi atu:Atu1141.
PATRICi 20812035. VBIAgrTum91616_1158.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci AGRO:ATU1141-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiPUR5_AGRT5
AccessioniPrimary (citable) accession number: Q8UG98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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