Aspartate--tRNA ligase - Agrobacterium tumefaciens (strain C58 / ATCC 33970)

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Q8UG87 (SYD_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Aspartate--tRNA ligase
EC=6.1.1.12

Alternative name(s):
Aspartyl-tRNA synthetase
Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	Atu1153
ORF Names:	AGR_C_2136

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970)

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044_B
Subunit structure	Homodimer By similarity. HAMAP MF_00044_B
Subcellular location	Cytoplasm HAMAP MF_00044_B.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tRNA aminoacylation for protein translation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 595

595

Aspartate--tRNA ligase HAMAP MF_00044_B

PRO_0000110816

Sequences

Sequence

Length

Mass (Da)

Tools

Q8UG87 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: BF5B88087D0ED4FE
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FASTA

595

67,035

        10         20         30         40         50         60 
MHRYRSHTCA ALRKSDVGET VRLSGWVHRV RDHGGVLFID LRDHYGITQV VADPDSPAFK 

        70         80         90        100        110        120 
VAETVRGEWV IRIDGLVKAR SEDTINKGMA TGEIELYAQE IEVLGVAKEL PLPVFGEPEY 

       130        140        150        160        170        180 
PEDVRLKYRF LDLRRETLHR NIVKRTQIIS SMRKGMGDLG FAEYTTPILT ASSPEGARDF 

       190        200        210        220        230        240 
LVPSRIHEGQ FFALPQAPQQ YKQLLMVAGF DRYFQIAPCF RDEDPRADRL PGEFYQLDVE 

       250        260        270        280        290        300 
MSFVTQEDVW TTMEPMMTAV FEQFAEGKPV TKQWPRIPYD ESIRKYGSDK PDLRNPIVME 

       310        320        330        340        350        360 
AVTEHFDGSG FKVFANMIAS NPKVQVWAIP AKTGGSRAFC DRMNAWAQSQ GQPGLGYIFW 

       370        380        390        400        410        420 
KEEEGKVAGS GPLAKNIGEE RTEALRQQLG LEAGDACFFV AGDPAKFYKF AGEARTRAAD 

       430        440        450        460        470        480 
ELNLIDRDRF EMCWIVDFPF FEYNEEEKKI DFAHNPFSMP QGGMEALEGQ DPLSIKAFQY 

       490        500        510        520        530        540 
DAVCNGFEIA SGSIRNQSPE LMVKAFEKVG LSQSDVEERF GGLYRAFQYG APPHGGCAFG 

       550        560        570        580        590 
IDRVVMLLVG AKNLREITLF PMNQQAQDLL MNAPSPATPT QLRELALRVV PSKKD

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References

[1]	"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.
[2]	"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007869 Genomic DNA. Translation: AAK86957.1.
PIR	AH2718. D97500.
RefSeq	NP_354172.1. NC_003062.2.
3D structure databases
ProteinModelPortal	Q8UG87.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UG87.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1133191.
GenomeReviews	Gene locus Atu1153 in contig AE007869_GR.
KEGG	atu:Atu1153.
PATRIC	20812063. VBIAgrTum91616_1172.
Phylogenomic databases
eggNOG	COG0173.
HOGENOM	HBG396032.
OMA	YQLDVEM.
PhylomeDB	Q8UG87.
ProtClustDB	PRK00476.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU1153-MONOMER.
Family and domain databases
HAMAP	MF_00044_B. Asp_tRNA_synth_B. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:3.30.1360.30. GAD_dom. 1 hit. G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01876.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF55261. SSF55261. 1 hit.
TIGRFAMs	TIGR00459. AspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_AGRT5

Accession

Primary (citable) accession number: Q8UG87

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents