Reviewed, UniProtKB/Swiss-Prot Q8UG00 (ARGC_AGRT5)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Atu1244
ORF Names:	AGR_C_2293

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_0000112502
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8UG00-1 [UniParc]. Last modified February 12, 2003. Version 2. Checksum: 60A2AAA320903317	FASTA	310	33,271
	10 20 30 40 50 60 MTAKIFIDGE HGTTGLQIRT RLAGRRDIEL LSIPETERRN AAMREDLLNN ADISILCLPD 70 80 90 100 110 120 DASKEAVSMV AGNNNVRIID TSTAYRVHQD WAYGFAEMDR DQGEKVRSAR FVANPGCYPT 130 140 150 160 170 180 GAIGLIRPLR ASGILPDGYP VSVNAVSGYT GGGKQMIAQM EDQSRDDAIS ANNFLYGLTL 190 200 210 220 230 240 KHKHVPEMTI HGQLDRAPLF APSVGRFPQG MIVQVPLFAA DLAEGTTIET IHAALTAHYA 250 260 270 280 290 300 GQDIVSVVPL AESKGISRID AEELAGKDTM KLFVFGTPGG EHINLVALLD NLGKGASGAA 310 VQNMELMLSA

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007869 Genomic DNA. Translation: AAK87041.2.
PIR	AG2729. H97510.
RefSeq	NP_354256.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UG00.
Genome annotation databases
GeneID	1133282.
GenomeReviews	Gene locus Atu1244 in contig AE007869_GR.
KEGG	atc:AGR_C_2293. atu:Atu1244.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	PIFVPSV.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU1244-MONOMER.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR010136. AGPR_subtype. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. argC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AGRT5

Accession

Primary (citable) accession number: Q8UG00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	February 12, 2003
Last modified:	February 9, 2010
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)