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Reviewed, UniProtKB/Swiss-Prot Q8UFK2 (LEXA_AGRT5)

Last modified February 9, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    LexA repressor
    EC=3.4.21.88
Gene names
Name: lexA
Ordered Locus Names: Atu1395
ORF Names: AGR_C_2577
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor lexA. HAMAP MF_00015

Subunit structure

Homodimer By similarity. HAMAP MF_00015

Sequence similarities

Belongs to the peptidase S24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240LexA repressor HAMAP MF_00015
PRO_0000169998

Regions

DNA binding26 – 4621H-T-H motif By similarity

Sites

Active site1601For autocatalytic cleavage activity By similarity
Active site1981For autocatalytic cleavage activity By similarity
Site125 – 1262Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UFK2-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2FA935A5EBA20180

FASTA24026,033
        10         20         30         40         50         60 
MLTRKQQELL LFIHERMKES GVPPSFDEMK DALDLASKSG IHRLITALEE RGFIRRLPNR 

        70         80         90        100        110        120 
ARALEVIKLP EAYTPGARPQ RGFSPSVIEG SLGKPKEPEP APAVKAPAND FAGAATIPVM 

       130        140        150        160        170        180 
GRIAAGVPIS AIQNNTHDLA VPVDMLGSGE HYALEVKGDS MIEAGIFDGD TVIIRNGNTA 

       190        200        210        220        230        240 
NPGDIVVALV DDEEATLKRF RRKGASIALE AANPAYETRI FGPDRVKIQG KLVGLIRRYH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK87187.1.
PIRAC2748.
B97529.
RefSeqNP_354402.1.

3D structure databases

SMRQ8UFK2. Positions 117-240.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8UFK2.

Protein family/group databases

MEROPSS24.001.

Genome annotation databases

GeneID1133433.
GenomeReviewsGene locus Atu1395 in contig AE007869_GR.
KEGGatc:AGR_C_2577.
atu:Atu1395.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
HOGENOMHBG679610.
OMAAILTFIR.

Enzyme and pathway databases

BioCycATUM176299-1:ATU1395-MONOMER.

Family and domain databases

HAMAPMF_00015. LexA.
[Tree]
InterProIPR006199. LexA_DNA-bd_dom.
IPR006200. Pept_S24_LexA.
IPR006197. Peptidase_S24_LexA_cons-reg.
IPR019759. Peptidase_S24_S26_cons-reg.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
TIGRFAMsTIGR00498. lexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEXA_AGRT5
AccessionPrimary (citable) accession number: Q8UFK2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2002
Last modified: February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents