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Q8UFD6

- GCSP_AGRT5

UniProt

Q8UFD6 - GCSP_AGRT5

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAGRO:ATU1462-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Atu1462
ORF Names:AGR_C_2699
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1462.

Structurei

3D structure databases

ProteinModelPortaliQ8UFD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UFD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPTEFHFT DYQPYDFANR RHIGPSPSEM AEMLKVVGYK SLDALIDATV
60 70 80 90 100
PSSIRQKVPL TWGAALTERE ALDRLRETAN KNQVLTSLIG QGYYGTITPP
110 120 130 140 150
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDVANAS
160 170 180 190 200
LLDEATAAAE AMAMCQRVAK SKATAFFVDA NCHPQTIALI ETRAAPLGWK
210 220 230 240 250
VIIGNPFTDL DPVDVFGAIF QYPGTHGHVS DFTGLISRLH QTGAIAAVAA
260 270 280 290 300
DLLALTLLKS PGEMGADIAI GTSQRFGVPV GYGGPHAAYM SVKDAHKRSM
310 320 330 340 350
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM
360 370 380 390 400
YGVFHGPQGI KAIAQQTHQK AVLMAKGLEK LGYTIEPETF FDTITVEVGH
410 420 430 440 450
MQGVILRSAV AEGVNLRKVG ATKIGMSLDE RTRPATLEAV WRAFGGNFSI
460 470 480 490 500
SDFEPDYRLP KDLLRTSQYM THPIFHMNRA ESEMTRYIRR LSDRDLALDR
510 520 530 540 550
SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPANQALG YKEMIDDLSE
560 570 580 590 600
KLCSVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHLANGGTH RDVCLIPTSA
610 620 630 640 650
HGTNPASAQM VGMKVVPVKV RDNGDIDIDD FRLKAEQYAE NLSCCMITYP
660 670 680 690 700
STHGVFEETV REICEITHKH GGQVYLDGAN MNAMVGLARP GDIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKAHLAPFL PGHPTTDGRE GAVSAAPFGS
760 770 780 790 800
PSILPISWSY CLMMGGEGLT QATKVAILNA NYIAERLKGA YDVLYKSETG
810 820 830 840 850
RVAHECIIDT RPLADSCGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP
860 870 880 890 900
TESETKAEID RFCDAMLAIR EEARDIEEGR ADKNNNPLKN APHTVEDLVG
910 920 930 940 950
EWDRPYSREK GCFPPGAFRI DKYWSPVNRI DNVYGDRNLI CTCPPMEAYA

EAAE
Length:954
Mass (Da):104,266
Last modified:June 1, 2002 - v1
Checksum:iFDFD3C73E8F42204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87254.1.
PIRiAF2756.
E97537.
RefSeqiNP_354469.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87254; AAK87254; Atu1462.
GeneIDi1133500.
KEGGiatu:Atu1462.
PATRICi20812701. VBIAgrTum91616_1485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87254.1 .
PIRi AF2756.
E97537.
RefSeqi NP_354469.1. NC_003062.2.

3D structure databases

ProteinModelPortali Q8UFD6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176299.Atu1462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK87254 ; AAK87254 ; Atu1462 .
GeneIDi 1133500.
KEGGi atu:Atu1462.
PATRICi 20812701. VBIAgrTum91616_1485.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AGRO:ATU1462-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiGCSP_AGRT5
AccessioniPrimary (citable) accession number: Q8UFD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3