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Q8UFD6

- GCSP_AGRT5

UniProt

Q8UFD6 - GCSP_AGRT5

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAGRO:ATU1462-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Atu1462
    ORF Names:AGR_C_2699
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166901Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi176299.Atu1462.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8UFD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8UFD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTPTEFHFT DYQPYDFANR RHIGPSPSEM AEMLKVVGYK SLDALIDATV    50
    PSSIRQKVPL TWGAALTERE ALDRLRETAN KNQVLTSLIG QGYYGTITPP 100
    VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDVANAS 150
    LLDEATAAAE AMAMCQRVAK SKATAFFVDA NCHPQTIALI ETRAAPLGWK 200
    VIIGNPFTDL DPVDVFGAIF QYPGTHGHVS DFTGLISRLH QTGAIAAVAA 250
    DLLALTLLKS PGEMGADIAI GTSQRFGVPV GYGGPHAAYM SVKDAHKRSM 300
    PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
    YGVFHGPQGI KAIAQQTHQK AVLMAKGLEK LGYTIEPETF FDTITVEVGH 400
    MQGVILRSAV AEGVNLRKVG ATKIGMSLDE RTRPATLEAV WRAFGGNFSI 450
    SDFEPDYRLP KDLLRTSQYM THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
    SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPANQALG YKEMIDDLSE 550
    KLCSVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHLANGGTH RDVCLIPTSA 600
    HGTNPASAQM VGMKVVPVKV RDNGDIDIDD FRLKAEQYAE NLSCCMITYP 650
    STHGVFEETV REICEITHKH GGQVYLDGAN MNAMVGLARP GDIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKAHLAPFL PGHPTTDGRE GAVSAAPFGS 750
    PSILPISWSY CLMMGGEGLT QATKVAILNA NYIAERLKGA YDVLYKSETG 800
    RVAHECIIDT RPLADSCGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
    TESETKAEID RFCDAMLAIR EEARDIEEGR ADKNNNPLKN APHTVEDLVG 900
    EWDRPYSREK GCFPPGAFRI DKYWSPVNRI DNVYGDRNLI CTCPPMEAYA 950
    EAAE 954
    Length:954
    Mass (Da):104,266
    Last modified:June 1, 2002 - v1
    Checksum:iFDFD3C73E8F42204
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK87254.1.
    PIRiAF2756.
    E97537.
    RefSeqiNP_354469.1. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK87254; AAK87254; Atu1462.
    GeneIDi1133500.
    KEGGiatu:Atu1462.
    PATRICi20812701. VBIAgrTum91616_1485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK87254.1 .
    PIRi AF2756.
    E97537.
    RefSeqi NP_354469.1. NC_003062.2.

    3D structure databases

    ProteinModelPortali Q8UFD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu1462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK87254 ; AAK87254 ; Atu1462 .
    GeneIDi 1133500.
    KEGGi atu:Atu1462.
    PATRICi 20812701. VBIAgrTum91616_1485.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AGRO:ATU1462-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiGCSP_AGRT5
    AccessioniPrimary (citable) accession number: Q8UFD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3