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Q8UFD6 (GCSP_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Atu1462
ORF Names:AGR_C_2699
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166901

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UFD6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: FDFD3C73E8F42204

FASTA954104,266
        10         20         30         40         50         60 
MTTPTEFHFT DYQPYDFANR RHIGPSPSEM AEMLKVVGYK SLDALIDATV PSSIRQKVPL 

        70         80         90        100        110        120 
TWGAALTERE ALDRLRETAN KNQVLTSLIG QGYYGTITPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNYQTMVCD LTGLDVANAS LLDEATAAAE AMAMCQRVAK SKATAFFVDA 

       190        200        210        220        230        240 
NCHPQTIALI ETRAAPLGWK VIIGNPFTDL DPVDVFGAIF QYPGTHGHVS DFTGLISRLH 

       250        260        270        280        290        300 
QTGAIAAVAA DLLALTLLKS PGEMGADIAI GTSQRFGVPV GYGGPHAAYM SVKDAHKRSM 

       310        320        330        340        350        360 
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YGVFHGPQGI 

       370        380        390        400        410        420 
KAIAQQTHQK AVLMAKGLEK LGYTIEPETF FDTITVEVGH MQGVILRSAV AEGVNLRKVG 

       430        440        450        460        470        480 
ATKIGMSLDE RTRPATLEAV WRAFGGNFSI SDFEPDYRLP KDLLRTSQYM THPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYIRR LSDRDLALDR SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPANQALG 

       550        560        570        580        590        600 
YKEMIDDLSE KLCSVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHLANGGTH RDVCLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM VGMKVVPVKV RDNGDIDIDD FRLKAEQYAE NLSCCMITYP STHGVFEETV 

       670        680        690        700        710        720 
REICEITHKH GGQVYLDGAN MNAMVGLARP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKAHLAPFL PGHPTTDGRE GAVSAAPFGS PSILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYIAERLKGA YDVLYKSETG RVAHECIIDT RPLADSCGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAEID RFCDAMLAIR EEARDIEEGR ADKNNNPLKN APHTVEDLVG 

       910        920        930        940        950 
EWDRPYSREK GCFPPGAFRI DKYWSPVNRI DNVYGDRNLI CTCPPMEAYA EAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK87254.1.
PIRAF2756.
E97537.
RefSeqNP_354469.1. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UFD6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu1462.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK87254; AAK87254; Atu1462.
GeneID1133500.
KEGGatu:Atu1462.
PATRIC20812701. VBIAgrTum91616_1485.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMATAYLTHP.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycAGRO:ATU1462-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_AGRT5
AccessionPrimary (citable) accession number: Q8UFD6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families