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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30GTPUniRule annotation1
Binding sitei58GTPUniRule annotation1
Binding sitei78GTPUniRule annotation1
Metal bindingi113MagnesiumUniRule annotation1
Binding sitei113GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 20GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAGRO:ATU1698-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:Atu1698
ORF Names:AGR_C_3120
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348771 – 218Molybdenum cofactor guanylyltransferaseAdd BLAST218

Proteomic databases

PRIDEiQ8UEQ7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1698

Structurei

3D structure databases

ProteinModelPortaliQ8UEQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R Bacteria
COG0746 LUCA
HOGENOMiHOG000280423
KOiK03752
OMAiIFVMAAP

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR02665 molyb_mobA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UEQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAPPRKIPG LVPPGLILAG GLSRRMGSNK AMVTLGDAPL LSHVIRRVTP
60 70 80 90 100
QVSDVTINAA ITDKGSWAEG FGLPLLPDTL NGHAGPLAGV LAGMRHFRDR
110 120 130 140 150
ETAGSHFLTA PADSPFFPND LVVRLCEHLS DDAIVIAASS GQLHPVFALW
160 170 180 190 200
PVALADDLED WLKNDANRRI RAFLARHVTI GVAFPPLETA RGSLDPFFNI
210
NTPDELALAR SQLETMET
Length:218
Mass (Da):23,402
Last modified:June 1, 2002 - v1
Checksum:iA95970D68BB09A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK87470.1
PIRiAD2785
E97564
RefSeqiNP_354685.1, NC_003062.2
WP_010971807.1, NC_003062.2

Genome annotation databases

EnsemblBacteriaiAAK87470; AAK87470; Atu1698
GeneIDi1133736
KEGGiatu:Atu1698
PATRICifig|176299.10.peg.1712

Similar proteinsi

Entry informationi

Entry nameiMOBA_AGRFC
AccessioniPrimary (citable) accession number: Q8UEQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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