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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301GTPUniRule annotation
Binding sitei58 – 581GTPUniRule annotation
Binding sitei78 – 781GTPUniRule annotation
Metal bindingi113 – 1131MagnesiumUniRule annotation
Binding sitei113 – 1131GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 203GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. molybdenum cofactor guanylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAGRO:ATU1698-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:Atu1698
ORF Names:AGR_C_3120
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Molybdenum cofactor guanylyltransferasePRO_0000134877Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1698.

Structurei

3D structure databases

ProteinModelPortaliQ8UEQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0746.
HOGENOMiHOG000280423.
KOiK03752.
OMAiEVAFPLH.
OrthoDBiEOG61041R.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA.
InterProiIPR025877. MobA-like_NTP_Trfase_dom.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR02665. molyb_mobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UEQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAPPRKIPG LVPPGLILAG GLSRRMGSNK AMVTLGDAPL LSHVIRRVTP
60 70 80 90 100
QVSDVTINAA ITDKGSWAEG FGLPLLPDTL NGHAGPLAGV LAGMRHFRDR
110 120 130 140 150
ETAGSHFLTA PADSPFFPND LVVRLCEHLS DDAIVIAASS GQLHPVFALW
160 170 180 190 200
PVALADDLED WLKNDANRRI RAFLARHVTI GVAFPPLETA RGSLDPFFNI
210
NTPDELALAR SQLETMET
Length:218
Mass (Da):23,402
Last modified:June 1, 2002 - v1
Checksum:iA95970D68BB09A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87470.1.
PIRiAD2785.
E97564.
RefSeqiNP_354685.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87470; AAK87470; Atu1698.
GeneIDi1133736.
KEGGiatu:Atu1698.
PATRICi20813167. VBIAgrTum91616_1712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87470.1.
PIRiAD2785.
E97564.
RefSeqiNP_354685.1. NC_003062.2.

3D structure databases

ProteinModelPortaliQ8UEQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu1698.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK87470; AAK87470; Atu1698.
GeneIDi1133736.
KEGGiatu:Atu1698.
PATRICi20813167. VBIAgrTum91616_1712.

Phylogenomic databases

eggNOGiCOG0746.
HOGENOMiHOG000280423.
KOiK03752.
OMAiEVAFPLH.
OrthoDBiEOG61041R.

Enzyme and pathway databases

BioCyciAGRO:ATU1698-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA.
InterProiIPR025877. MobA-like_NTP_Trfase_dom.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR02665. molyb_mobA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiMOBA_AGRT5
AccessioniPrimary (citable) accession number: Q8UEQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.