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Q8UEK8 (GCH1_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:Atu1749
ORF Names:AGR_C_3211
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119378

Sites

Metal binding981Zinc By similarity
Metal binding1011Zinc By similarity
Metal binding1691Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UEK8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C490D5484D729C52

FASTA20823,031
        10         20         30         40         50         60 
MDAIVKNFPG AGAKPDVAEA RPSQAEAEEA VRVLLRWAGE NPAREGLLDT PKRVAKAYRE 

        70         80         90        100        110        120 
LFAGYELNVQ DVLGTTFEEV GGYDDVVLVR DIPFFSHCEH HMVPIVGKAH VAYLPAGRVL 

       130        140        150        160        170        180 
GLSKIARVVE IFGRRLQTQE NMTAQIARSI EETLKPRGVA VMIDAEHMCM SMRGVNKQGS 

       190        200 
TTLTTSFTGT FKNDPAEQVR FMTMVRNR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK87519.1.
PIRAF2791.
F97570.
RefSeqNP_354734.1. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UEK8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu1749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK87519; AAK87519; Atu1749.
GeneID1133787.
KEGGatu:Atu1749.
PATRIC20813269. VBIAgrTum91616_1762.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAGENPARE.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycAGRO:ATU1749-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_AGRT5
AccessionPrimary (citable) accession number: Q8UEK8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways