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Q8UEH1

- GLMS_AGRT5

UniProt

Q8UEH1 - GLMS_AGRT5

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei603 – 6031For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciAGRO:ATU1786-MONOMER.
RETL1328306-WGS:GSTH-2099-MONOMER.
RETL1328306-WGS:GSTH-793-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Atu1786
ORF Names:AGR_C_3284
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135291Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1786.

Structurei

3D structure databases

ProteinModelPortaliQ8UEH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini281 – 422142SIS 1UniRule annotationAdd
BLAST
Domaini456 – 598143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiQVISWSE.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8UEH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGIVGT QPVAERLVDA LKRLEYRGYD SAGVATIDNG AMDRRRAEGK
60 70 80 90 100
LFNLEKLVSE KPLPGVVGIA HTRWATHGVP NEINAHPHFV DGVAVVHNGI
110 120 130 140 150
IENFSELREE LSAEGATFTT QTDTEVVAQL LAKYTREGLG HREAMLKMLN
160 170 180 190 200
HVTGAYALVV MFQDDPGTLL SARSGPPLAV GYGRGEMFLG SDAIALSPFT
210 220 230 240 250
NEITYLVDGD CAIVTRDGAE IIDFSGKPVK RERQISQATA FVVDKGNHRH
260 270 280 290 300
FMEKEIYEQP EVISHALSHY VDFATRTVKD ADKAIDFASL SGLAISACGT
310 320 330 340 350
AYLSGLIGKY WFERYARLPV EIDVASEFRY REIPLVPTQA ALFISQSGET
360 370 380 390 400
ADTLAALRYC QQEGLKIGAV VNTRESTMAR ESDAIFPILA GPEIGVASTK
410 420 430 440 450
AFTCQLAVLA SLAVAAGKAR GTLKPGEEKQ LVQQLIEMPR IMSKVLNVIQ
460 470 480 490 500
PQIEALSRDL SRFKDVLYLG RGTSFPLALE GALKLKEISY IHAEGYAAGE
510 520 530 540 550
LKHGPIALID ENMPVIVIAP HDRFFEKTVS NMQEVAARGG RIIFITDEKG
560 570 580 590 600
AAASKLETMA TITLPNVDEL IAPMVFSLPI QLLAYHTAVF MGTDVDQPRN

LAKSVTVE
Length:608
Mass (Da):66,113
Last modified:January 23, 2007 - v3
Checksum:iFC16E5382902C073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87556.1.
PIRiAC2796.
C97575.
RefSeqiNP_354771.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87556; AAK87556; Atu1786.
GeneIDi1133824.
KEGGiatu:Atu1786.
PATRICi20813347. VBIAgrTum91616_1801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87556.1 .
PIRi AC2796.
C97575.
RefSeqi NP_354771.1. NC_003062.2.

3D structure databases

ProteinModelPortali Q8UEH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176299.Atu1786.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK87556 ; AAK87556 ; Atu1786 .
GeneIDi 1133824.
KEGGi atu:Atu1786.
PATRICi 20813347. VBIAgrTum91616_1801.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi QVISWSE.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci AGRO:ATU1786-MONOMER.
RETL1328306-WGS:GSTH-2099-MONOMER.
RETL1328306-WGS:GSTH-793-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiGLMS_AGRT5
AccessioniPrimary (citable) accession number: Q8UEH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3