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Q8UEH1

- GLMS_AGRT5

UniProt

Q8UEH1 - GLMS_AGRT5

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei603 – 6031For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciAGRO:ATU1786-MONOMER.
    RETL1328306-WGS:GSTH-2099-MONOMER.
    RETL1328306-WGS:GSTH-793-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:Atu1786
    ORF Names:AGR_C_3284
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135291Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi176299.Atu1786.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8UEH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini281 – 422142SIS 1UniRule annotationAdd
    BLAST
    Domaini456 – 598143SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiQVISWSE.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8UEH1-1 [UniParc]FASTAAdd to Basket

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    MCGIVGIVGT QPVAERLVDA LKRLEYRGYD SAGVATIDNG AMDRRRAEGK    50
    LFNLEKLVSE KPLPGVVGIA HTRWATHGVP NEINAHPHFV DGVAVVHNGI 100
    IENFSELREE LSAEGATFTT QTDTEVVAQL LAKYTREGLG HREAMLKMLN 150
    HVTGAYALVV MFQDDPGTLL SARSGPPLAV GYGRGEMFLG SDAIALSPFT 200
    NEITYLVDGD CAIVTRDGAE IIDFSGKPVK RERQISQATA FVVDKGNHRH 250
    FMEKEIYEQP EVISHALSHY VDFATRTVKD ADKAIDFASL SGLAISACGT 300
    AYLSGLIGKY WFERYARLPV EIDVASEFRY REIPLVPTQA ALFISQSGET 350
    ADTLAALRYC QQEGLKIGAV VNTRESTMAR ESDAIFPILA GPEIGVASTK 400
    AFTCQLAVLA SLAVAAGKAR GTLKPGEEKQ LVQQLIEMPR IMSKVLNVIQ 450
    PQIEALSRDL SRFKDVLYLG RGTSFPLALE GALKLKEISY IHAEGYAAGE 500
    LKHGPIALID ENMPVIVIAP HDRFFEKTVS NMQEVAARGG RIIFITDEKG 550
    AAASKLETMA TITLPNVDEL IAPMVFSLPI QLLAYHTAVF MGTDVDQPRN 600
    LAKSVTVE 608
    Length:608
    Mass (Da):66,113
    Last modified:January 23, 2007 - v3
    Checksum:iFC16E5382902C073
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK87556.1.
    PIRiAC2796.
    C97575.
    RefSeqiNP_354771.1. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK87556; AAK87556; Atu1786.
    GeneIDi1133824.
    KEGGiatu:Atu1786.
    PATRICi20813347. VBIAgrTum91616_1801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK87556.1 .
    PIRi AC2796.
    C97575.
    RefSeqi NP_354771.1. NC_003062.2.

    3D structure databases

    ProteinModelPortali Q8UEH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu1786.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK87556 ; AAK87556 ; Atu1786 .
    GeneIDi 1133824.
    KEGGi atu:Atu1786.
    PATRICi 20813347. VBIAgrTum91616_1801.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi QVISWSE.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci AGRO:ATU1786-MONOMER.
    RETL1328306-WGS:GSTH-2099-MONOMER.
    RETL1328306-WGS:GSTH-793-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiGLMS_AGRT5
    AccessioniPrimary (citable) accession number: Q8UEH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3