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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei603For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciAGRO:ATU1786-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Atu1786
ORF Names:AGR_C_3284
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001352912 – 608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST607

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1786.

Structurei

3D structure databases

ProteinModelPortaliQ8UEH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini281 – 422SIS 1UniRule annotationAdd BLAST142
Domaini456 – 598SIS 2UniRule annotationAdd BLAST143

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiTIDNGAM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8UEH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGIVGT QPVAERLVDA LKRLEYRGYD SAGVATIDNG AMDRRRAEGK
60 70 80 90 100
LFNLEKLVSE KPLPGVVGIA HTRWATHGVP NEINAHPHFV DGVAVVHNGI
110 120 130 140 150
IENFSELREE LSAEGATFTT QTDTEVVAQL LAKYTREGLG HREAMLKMLN
160 170 180 190 200
HVTGAYALVV MFQDDPGTLL SARSGPPLAV GYGRGEMFLG SDAIALSPFT
210 220 230 240 250
NEITYLVDGD CAIVTRDGAE IIDFSGKPVK RERQISQATA FVVDKGNHRH
260 270 280 290 300
FMEKEIYEQP EVISHALSHY VDFATRTVKD ADKAIDFASL SGLAISACGT
310 320 330 340 350
AYLSGLIGKY WFERYARLPV EIDVASEFRY REIPLVPTQA ALFISQSGET
360 370 380 390 400
ADTLAALRYC QQEGLKIGAV VNTRESTMAR ESDAIFPILA GPEIGVASTK
410 420 430 440 450
AFTCQLAVLA SLAVAAGKAR GTLKPGEEKQ LVQQLIEMPR IMSKVLNVIQ
460 470 480 490 500
PQIEALSRDL SRFKDVLYLG RGTSFPLALE GALKLKEISY IHAEGYAAGE
510 520 530 540 550
LKHGPIALID ENMPVIVIAP HDRFFEKTVS NMQEVAARGG RIIFITDEKG
560 570 580 590 600
AAASKLETMA TITLPNVDEL IAPMVFSLPI QLLAYHTAVF MGTDVDQPRN

LAKSVTVE
Length:608
Mass (Da):66,113
Last modified:January 23, 2007 - v3
Checksum:iFC16E5382902C073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87556.1.
PIRiAC2796.
C97575.
RefSeqiNP_354771.1. NC_003062.2.
WP_010971865.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87556; AAK87556; Atu1786.
GeneIDi1133824.
KEGGiatu:Atu1786.
PATRICi20813347. VBIAgrTum91616_1801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87556.1.
PIRiAC2796.
C97575.
RefSeqiNP_354771.1. NC_003062.2.
WP_010971865.1. NC_003062.2.

3D structure databases

ProteinModelPortaliQ8UEH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu1786.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK87556; AAK87556; Atu1786.
GeneIDi1133824.
KEGGiatu:Atu1786.
PATRICi20813347. VBIAgrTum91616_1801.

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiTIDNGAM.

Enzyme and pathway databases

BioCyciAGRO:ATU1786-MONOMER.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_AGRFC
AccessioniPrimary (citable) accession number: Q8UEH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.