Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei603For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciAGRO:ATU1786-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Atu1786
ORF Names:AGR_C_3284
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001352912 – 608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST607

Proteomic databases

PRIDEiQ8UEH1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1786

Structurei

3D structure databases

ProteinModelPortaliQ8UEH1
SMRiQ8UEH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini281 – 422SIS 1UniRule annotationAdd BLAST142
Domaini456 – 598SIS 2UniRule annotationAdd BLAST143

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiRLDSSTC

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8UEH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGIVGT QPVAERLVDA LKRLEYRGYD SAGVATIDNG AMDRRRAEGK
60 70 80 90 100
LFNLEKLVSE KPLPGVVGIA HTRWATHGVP NEINAHPHFV DGVAVVHNGI
110 120 130 140 150
IENFSELREE LSAEGATFTT QTDTEVVAQL LAKYTREGLG HREAMLKMLN
160 170 180 190 200
HVTGAYALVV MFQDDPGTLL SARSGPPLAV GYGRGEMFLG SDAIALSPFT
210 220 230 240 250
NEITYLVDGD CAIVTRDGAE IIDFSGKPVK RERQISQATA FVVDKGNHRH
260 270 280 290 300
FMEKEIYEQP EVISHALSHY VDFATRTVKD ADKAIDFASL SGLAISACGT
310 320 330 340 350
AYLSGLIGKY WFERYARLPV EIDVASEFRY REIPLVPTQA ALFISQSGET
360 370 380 390 400
ADTLAALRYC QQEGLKIGAV VNTRESTMAR ESDAIFPILA GPEIGVASTK
410 420 430 440 450
AFTCQLAVLA SLAVAAGKAR GTLKPGEEKQ LVQQLIEMPR IMSKVLNVIQ
460 470 480 490 500
PQIEALSRDL SRFKDVLYLG RGTSFPLALE GALKLKEISY IHAEGYAAGE
510 520 530 540 550
LKHGPIALID ENMPVIVIAP HDRFFEKTVS NMQEVAARGG RIIFITDEKG
560 570 580 590 600
AAASKLETMA TITLPNVDEL IAPMVFSLPI QLLAYHTAVF MGTDVDQPRN

LAKSVTVE
Length:608
Mass (Da):66,113
Last modified:January 23, 2007 - v3
Checksum:iFC16E5382902C073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK87556.1
PIRiAC2796
C97575
RefSeqiNP_354771.1, NC_003062.2
WP_010971865.1, NC_003062.2

Genome annotation databases

EnsemblBacteriaiAAK87556; AAK87556; Atu1786
GeneIDi1133824
KEGGiatu:Atu1786
PATRICifig|176299.10.peg.1801

Entry informationi

Entry nameiGLMS_AGRFC
AccessioniPrimary (citable) accession number: Q8UEH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health