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Protein

Glutaminase

Gene

glsA

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei114 – 1141SubstrateUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Binding sitei261 – 2611Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAGRO:ATU1859-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:Atu1859
ORF Names:AGR_C_3412
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813 Componenti: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GlutaminasePRO_0000110586Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu1859.

Structurei

3D structure databases

ProteinModelPortaliQ8UEA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UEA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDIQGIVDS IYDSMLPRLG EGKVADYIPE LAKVDPNQFG IAITTVDGTT
60 70 80 90 100
YTAGNALVPF SIQSISKVFM LTLALGKAGE TVWNRVGREP SGSSFNSIVQ
110 120 130 140 150
LEHEHGIPRN PFVNAGAIVV TDIVLSGHQP REAIGELLRF VRYLADDDTI
160 170 180 190 200
SIDDTVAKSE QATGFRNFAL ANFMRSFGNL HHPVEHTLGV YFHQCALSMT
210 220 230 240 250
CAQLSRAGLF LANRGRNPLS GHTVVSDRRA RRINALMLTC GHYDGSGDFA
260 270 280 290 300
YHVGLPGKSG VGGGIMAVAP GNASIAVWSP GLNKVGNSAL GSQALELLAT

KTGWSVFGA
Length:309
Mass (Da):32,926
Last modified:June 1, 2002 - v1
Checksum:i65229FEFE6CC1135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87626.1.
PIRiA97584.
AI2804.
RefSeqiNP_354841.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87626; AAK87626; Atu1859.
GeneIDi1133897.
KEGGiatu:Atu1859.
PATRICi20813495. VBIAgrTum91616_1872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87626.1.
PIRiA97584.
AI2804.
RefSeqiNP_354841.1. NC_003062.2.

3D structure databases

ProteinModelPortaliQ8UEA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu1859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK87626; AAK87626; Atu1859.
GeneIDi1133897.
KEGGiatu:Atu1859.
PATRICi20813495. VBIAgrTum91616_1872.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciAGRO:ATU1859-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiGLSA_AGRT5
AccessioniPrimary (citable) accession number: Q8UEA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.