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Q8UDN3 (DDL_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Atu2089
ORF Names:AGR_C_3788
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177777

Regions

Domain102 – 302201ATP-grasp
Nucleotide binding128 – 18356ATP By similarity

Sites

Metal binding2521Magnesium or manganese 1 By similarity
Metal binding2691Magnesium or manganese 1 By similarity
Metal binding2691Magnesium or manganese 2 By similarity
Metal binding2711Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8UDN3 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: 18A95347199404E8

FASTA30833,069
        10         20         30         40         50         60 
MGGKHVAVLL GGFSSERPVS LSSGNACALA LEGEGYKVTR VDVGRDVAAV LDELRPDVAF 

        70         80         90        100        110        120 
NALHGPFGED GTIQGILEYL AIPYTHSGVL ASALAMDKAQ AKKVAAAAGI PVAGERVMNR 

       130        140        150        160        170        180 
FDFTSEHPLQ PPYVVKPVRE GSSFGVVIVK EDQSHPPQIL TSSEWPFGNQ VMVERYIHGR 

       190        200        210        220        230        240 
ELTCGVLDGE ALGVTEVVPL GHNFYDYDAK YAAGGSKHVI PAGISPKIYQ KIQTLAVMAH 

       250        260        270        280        290        300 
QAIGCRGVSR SDFRYDDRFS EDGEVIWLEV NTQPGMTPTS LVPEMAAHAG RSFGDLVSWM 


VEDASCLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK87839.2.
PIRAB2833.
F97610.
RefSeqNP_355054.2. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UDN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu2089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK87839; AAK87839; Atu2089.
GeneID1134127.
KEGGatu:Atu2089.
PATRIC20813963. VBIAgrTum91616_2102.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAKYTEGFA.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycAGRO:ATU2089-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_AGRT5
AccessionPrimary (citable) accession number: Q8UDN3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: February 19, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways