Phospho-N-acetylmuramoyl-pentapeptide-transferase - Agrobacterium tumefaciens (strain C58 / ATCC 33970)

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Reviewed, UniProtKB/Swiss-Prot Q8UDM5 (MRAY_AGRT5)

Last modified November 3, 2009. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase

Gene names

Name:	mraY
Ordered Locus Names:	Atu2097
ORF Names:	AGR_C_3805

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

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Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.
Catalytic activity	UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 4 family. MraY subfamily.

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Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	phospho-N-acetylmuramoyl-pentapeptide-transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 366

366

Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038

PRO_0000108769

Regions

Transmembrane

25 – 45

Potential

Transmembrane

70 – 90

Potential

Transmembrane

93 – 113

Potential

Transmembrane

134 – 154

Potential

Transmembrane

174 – 194

Potential

Transmembrane

205 – 225

Potential

Transmembrane

245 – 265

Potential

Transmembrane

268 – 288

Potential

Transmembrane

297 – 317

Potential

Transmembrane

343 – 363

Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8UDM5-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B08E23B0BAEA0559
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FASTA

366

39,127

        10         20         30         40         50         60 
MLIWLVELSD KVQLFNLFRY ITFRAGAAMF TSALIVFLFG PAIINSLRVR QGKGQPIRAD 

        70         80         90        100        110        120 
GPQTHFKKAG TPTMGGLMIL AGILGGSLLW GDLSNVYVVA VLMVTLGFGA IGFYDDYLKV 

       130        140        150        160        170        180 
TKQSDKGFSG KARLGIEFLI AAIAVFFMMK MALASAPHGG TLGSSIAFPF FKEFVINLGY 

       190        200        210        220        230        240 
FFVLFGAFVI VGAGNAVNLT DGLDGLAIVP VMIAAATFGV IAYLAGNAVF ANYLQINFVP 

       250        260        270        280        290        300 
GTGELAVIVG AVIGAGLGFL WFNAPPAAIF MGDTGSLALG GLIGSIAVAT KHEIVMVIVG 

       310        320        330        340        350        360 
GLFVMETLSV IIQVFWFKRT GRRVFLMAPI HHHFEKKGWT ESQVVIRFWI ISVGLALLGL 


ATLKLR

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References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58."
Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J.

Nester E.W.
Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58."
Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C.

Slater S.
Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases
	AE007869 Genomic DNA. Translation: AAK87847.1.
PIR	AB2834. F97611.
RefSeq	NP_355062.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UDM5.
Genome annotation databases
GeneID	1134135.
GenomeReviews	Gene locus Atu2097 in contig AE007869_GR.
KEGG	atc:AGR_C_3805. atu:Atu2097.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8UDM5.
OMA	HHHFEQK.
Family and domain databases
HAMAP	MF_00038. [Tree]
InterPro	IPR000715. Glycosyl_transferase_4. IPR018481. Glycosyl_Trfase_4_cons-reg. IPR003524. PNAcMuramoyl-5peptid_Trfase. IPR018480. PNAcMuramoyl-5peptid_Trfase_CS. [Graphical view]
PANTHER	PTHR22926. Glyco_trans_4. 1 hit. PTHR22926:SF3. PNAcPpept_trans. 1 hit.
Pfam	PF00953. Glycos_transf_4. 1 hit. PF10555. MraY_sig1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00445. mraY. 1 hit.
PROSITE	PS01347. MRAY_1. 1 hit. PS01348. MRAY_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

MRAY_AGRT5

Accession

Primary (citable) accession number: Q8UDM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents