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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAGRO:ATU2097-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Atu2097
ORF Names:AGR_C_3805
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei174 – 194HelicalUniRule annotationAdd BLAST21
Transmembranei205 – 225HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21
Transmembranei297 – 317HelicalUniRule annotationAdd BLAST21
Transmembranei343 – 363HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001087691 – 366Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST366

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu2097.

Structurei

3D structure databases

ProteinModelPortaliQ8UDM5.
SMRiQ8UDM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UDM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIWLVELSD KVQLFNLFRY ITFRAGAAMF TSALIVFLFG PAIINSLRVR
60 70 80 90 100
QGKGQPIRAD GPQTHFKKAG TPTMGGLMIL AGILGGSLLW GDLSNVYVVA
110 120 130 140 150
VLMVTLGFGA IGFYDDYLKV TKQSDKGFSG KARLGIEFLI AAIAVFFMMK
160 170 180 190 200
MALASAPHGG TLGSSIAFPF FKEFVINLGY FFVLFGAFVI VGAGNAVNLT
210 220 230 240 250
DGLDGLAIVP VMIAAATFGV IAYLAGNAVF ANYLQINFVP GTGELAVIVG
260 270 280 290 300
AVIGAGLGFL WFNAPPAAIF MGDTGSLALG GLIGSIAVAT KHEIVMVIVG
310 320 330 340 350
GLFVMETLSV IIQVFWFKRT GRRVFLMAPI HHHFEKKGWT ESQVVIRFWI
360
ISVGLALLGL ATLKLR
Length:366
Mass (Da):39,127
Last modified:June 1, 2002 - v1
Checksum:iB08E23B0BAEA0559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87847.1.
PIRiAB2834.
F97611.
RefSeqiNP_355062.1. NC_003062.2.
WP_006310449.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87847; AAK87847; Atu2097.
GeneIDi1134135.
KEGGiatu:Atu2097.
PATRICifig|176299.10.peg.2111.

Similar proteinsi

Entry informationi

Entry nameiMRAY_AGRFC
AccessioniPrimary (citable) accession number: Q8UDM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families