Reviewed,
UniProtKB/Swiss-Prot Q8UC31 (ASSY_AGRT5)
Last modified
September 1, 2009.
Version 50.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Argininosuccinate synthase EC=6.3.4.5 Alternative name(s): Citrulline--aspartate ligase | ||||||
| Gene names |
| ||||||
| Organism | Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 176299 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium |
Protein attributes
| Sequence length | 407 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP MF_00005 |
| Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP MF_00005 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the argininosuccinate synthase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Arginine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP argininosuccinate synthase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 407 | 407 | Argininosuccinate synthase HAMAP MF_00005 | PRO_0000148560 | |||||
Regions | |||||||||
| Nucleotide binding | 13 – 21 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 40 | 1 | ATP; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Binding site | 91 | 1 | Citrulline By similarity | ||||||
| Binding site | 96 | 1 | Citrulline By similarity | ||||||
| Binding site | 121 | 1 | ATP; via amide nitrogen By similarity | ||||||
| Binding site | 123 | 1 | Aspartate By similarity | ||||||
| Binding site | 127 | 1 | Aspartate By similarity | ||||||
| Binding site | 127 | 1 | Citrulline By similarity | ||||||
| Binding site | 128 | 1 | Aspartate By similarity | ||||||
| Binding site | 131 | 1 | Citrulline By similarity | ||||||
| Binding site | 182 | 1 | Citrulline By similarity | ||||||
| Binding site | 191 | 1 | Citrulline By similarity | ||||||
| Binding site | 267 | 1 | Citrulline By similarity | ||||||
| Binding site | 279 | 1 | Citrulline By similarity | ||||||
Sequences
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References
| [1] | "The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J.  Nester E.W.Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. Slater S.Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AE007869 Genomic DNA. Translation: AAK88389.2. | |
| PIR | AB2904. D97679. |
| RefSeq | NP_355604.2. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8UC31. |
Genome annotation databases | |
| GeneID | 1134705. |
| GenomeReviews | Gene locus Atu2667 in contig AE007869_GR. |
| KEGG | atc:AGR_C_4836. atu:Atu2667. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8UC31. |
Family and domain databases | |
| HAMAP | MF_00005. [Tree] |
| InterPro | IPR001518. Arginosuc_synth. IPR018223. Arginosuc_synth_CS. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| PANTHER | PTHR11587. Arginosuc_synth. 1 hit. |
| Pfam | PF00764. Arginosuc_synth. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00032. argG. 1 hit. |
| PROSITE | PS00564. ARGININOSUCCIN_SYN_1. 1 hit. PS00565. ARGININOSUCCIN_SYN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ASSY_AGRT5 | ||||||||
| Accession | Primary (citable) accession number: Q8UC31 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
