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Q8UBV2

- SYL_AGRT5

UniProt

Q8UBV2 - SYL_AGRT5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAGRO:ATU2748-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Atu2748
    ORF Names:AGR_C_4985
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome circular

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_0000151960Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176299.Atu2748.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8UBV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8UBV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIERYNPRD AEPRWQQKWN EDKVFVTDNS DPREKYYVLE MFPYPSGRIH    50
    MGHVRNYAMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMQNKVHPKD 100
    WTYQNIATMR GQLKSMGLSL DWTREFATCD VEYYHRQQAL FVDFMEKGLV 150
    YRKQSKVNWD PVDHTVLANE QVIDGRGWRS GALVEQRELT QWFFRITDFS 200
    QDLLDELDEL DQWPEKVRLM QKNWIGRSEG LSLRWQTVAD TAPQGFSDIT 250
    VYTTRPDTLF GASFLAIAAD HPLAKELSAT NPAIAEFCDE CRRHGTSLAA 300
    LETAEKKGID TGVKVVHPLD PSWELPVYVA NFVLMDYGTG AIFGCPSGDQ 350
    RDLDFARKYG LPVVAVVAPE GPDAASFTVE DTAFTDDGVM INSSFLNGMK 400
    TTDAFEAVVQ KLSAQSLGNA PQAERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CEVCGVVPVP KKDLPVKLPD DVTFDVPGNP LDRHSTWRHV SCPQCGHDAR 500
    RETDTMDTFV DSSWYYTRFT APWEDEPTDP QVANHWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMRETGHVG VKEPFKGLFT QGMVVHETYS RGEGLTREWV 600
    PPAELRIEEN DGTRRAFLLS SGEEVKIGSI EKMSKSKKNV VDPDDIIASY 650
    GADTARFFVL SDSPPDRDVI WSEAGVEGAN RFVQRVWRII GEAAEQLKGV 700
    KPKPATEGEG LAASKAAHKT LKAVQEDLDK LAFNKAIARI YELVNALAGP 750
    LADVAAGGKP DNVKAAARDA VEILIRIIAP MTPHLAEECW SALGNEGLVA 800
    ETPWPTFVAS LVEENDVVMP VQVNGKKRGE LTIARDADQD AVRTAALELD 850
    AVKSILAGGE PKKVIVVPQR IVNIVV 876
    Length:876
    Mass (Da):98,018
    Last modified:June 1, 2002 - v1
    Checksum:iAB4856E88F7EE9DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK88463.1.
    PIRiAC2914.
    F97688.
    RefSeqiNP_355678.1. NC_003062.2.

    Genome annotation databases

    EnsemblBacteriaiAAK88463; AAK88463; Atu2748.
    GeneIDi1134786.
    KEGGiatu:Atu2748.
    PATRICi20815291. VBIAgrTum91616_2758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007869 Genomic DNA. Translation: AAK88463.1 .
    PIRi AC2914.
    F97688.
    RefSeqi NP_355678.1. NC_003062.2.

    3D structure databases

    ProteinModelPortali Q8UBV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu2748.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK88463 ; AAK88463 ; Atu2748 .
    GeneIDi 1134786.
    KEGGi atu:Atu2748.
    PATRICi 20815291. VBIAgrTum91616_2758.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AGRO:ATU2748-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiSYL_AGRT5
    AccessioniPrimary (citable) accession number: Q8UBV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3