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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:Atu2779
ORF Names:AGR_C_5042
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896821 – 428Gamma-glutamyl phosphate reductaseAdd BLAST428

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu2779

Structurei

3D structure databases

ProteinModelPortaliQ8UBS1
SMRiQ8UBS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S Bacteria
COG0014 LUCA
HOGENOMiHOG000246356
KOiK00147
OMAiHGSHHTD

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UBS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQAVKQSH DIDALMMTIG AQAKAASRPL SIAGTDQKNR ALLAMASAIE
60 70 80 90 100
ASKEAILAAN RKDLAAAESA GLAASFVDRL TLNDARIAGI AEGIRSVAAL
110 120 130 140 150
ADPVGEVIAA WDRPNGLKIE RVRTPLGVIG VIYESRPNVT ADAGALCLKA
160 170 180 190 200
GNAVILRGGS DSQHSSRAIH ACLVQGLRIA GLPENAIQLV PVTDRAAVGA
210 220 230 240 250
LLSGLKGTVD VIVPRGGKSL VARVQSEARV PVFAHLEGIC HIYVDKSADL
260 270 280 290 300
DMAKAIVVNA KMRRTGICGA AETLLVDASA VSSHLEPVVK ALLDAGCEVR
310 320 330 340 350
GSQPVRNVVE GLEAATEEDW RTEYLDAIIS VAVVDGISGA IEHIGTYSSN
360 370 380 390 400
HTEAVIAEDP DVVARFFNEL DSAILLHNAS TQFADGGEFG MGAEIGIATG
410 420
KMHARGPVGV EQLTSFKYRV HGTGQTRT
Length:428
Mass (Da):44,630
Last modified:September 13, 2004 - v2
Checksum:i33266C27681C1F9B
GO

Sequence cautioni

The sequence AAK88494 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK88494.2 Different initiation.
PIRiAB2918
E97692
RefSeqiNP_355709.2, NC_003062.2

Genome annotation databases

EnsemblBacteriaiAAK88494; AAK88494; Atu2779
GeneIDi1134817
KEGGiatu:Atu2779
PATRICifig|176299.10.peg.2789

Similar proteinsi

Entry informationi

Entry nameiPROA_AGRFC
AccessioniPrimary (citable) accession number: Q8UBS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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