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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:Atu2779
ORF Names:AGR_C_5042
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Gamma-glutamyl phosphate reductasePRO_0000189682Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu2779.

Structurei

3D structure databases

ProteinModelPortaliQ8UBS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S. Bacteria.
COG0014. LUCA.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
IPR000965. GPR_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8UBS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQAVKQSH DIDALMMTIG AQAKAASRPL SIAGTDQKNR ALLAMASAIE
60 70 80 90 100
ASKEAILAAN RKDLAAAESA GLAASFVDRL TLNDARIAGI AEGIRSVAAL
110 120 130 140 150
ADPVGEVIAA WDRPNGLKIE RVRTPLGVIG VIYESRPNVT ADAGALCLKA
160 170 180 190 200
GNAVILRGGS DSQHSSRAIH ACLVQGLRIA GLPENAIQLV PVTDRAAVGA
210 220 230 240 250
LLSGLKGTVD VIVPRGGKSL VARVQSEARV PVFAHLEGIC HIYVDKSADL
260 270 280 290 300
DMAKAIVVNA KMRRTGICGA AETLLVDASA VSSHLEPVVK ALLDAGCEVR
310 320 330 340 350
GSQPVRNVVE GLEAATEEDW RTEYLDAIIS VAVVDGISGA IEHIGTYSSN
360 370 380 390 400
HTEAVIAEDP DVVARFFNEL DSAILLHNAS TQFADGGEFG MGAEIGIATG
410 420
KMHARGPVGV EQLTSFKYRV HGTGQTRT
Length:428
Mass (Da):44,630
Last modified:September 13, 2004 - v2
Checksum:i33266C27681C1F9B
GO

Sequence cautioni

The sequence AAK88494 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK88494.2. Different initiation.
PIRiAB2918.
E97692.
RefSeqiNP_355709.2. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK88494; AAK88494; Atu2779.
GeneIDi1134817.
KEGGiatu:Atu2779.
PATRICi20815353. VBIAgrTum91616_2789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK88494.2. Different initiation.
PIRiAB2918.
E97692.
RefSeqiNP_355709.2. NC_003062.2.

3D structure databases

ProteinModelPortaliQ8UBS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu2779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK88494; AAK88494; Atu2779.
GeneIDi1134817.
KEGGiatu:Atu2779.
PATRICi20815353. VBIAgrTum91616_2789.

Phylogenomic databases

eggNOGiENOG4105C2S. Bacteria.
COG0014. LUCA.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
IPR000965. GPR_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROA_AGRFC
AccessioniPrimary (citable) accession number: Q8UBS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.