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Q8UBM8 (PUR9_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Atu2823
ORF Names:AGR_C_5117
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Reference proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium › Agrobacterium tumefaciens complex ›

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192066

Sequences

Sequence LengthMass (Da)Tools
Q8UBM8 [UniParc].

Last modified June 20, 2003. Version 2.
Checksum: A08254F00C5764BC

FASTA53856,891
        10         20         30         40         50         60 
MAVVSKKIPA PDKVKIRTAL LSVSDKTDII ELATVLSKLG VKLLSTGGTA KAIAEAGLAV 

        70         80         90        100        110        120 
TDVSDVTNFP EIMDGRVKTL HPNVHGGLLA IRDDAEHVEA MKAHGIEAID LSVINLYPFE 

       130        140        150        160        170        180 
EVRAKGGDYP TTVENIDIGG PAMIRASAKN HAYVTVVTDP SDYPALVEAL QADDGQTSYA 

       190        200        210        220        230        240 
LRQRFAAKAY ARTAAYDAVI SNWFAEALAI ETPHYRAIGG VLKEKMRYGE NPHQSAGFYL 

       250        260        270        280        290        300 
TGEKRPGVAT ATLLQGKQLS YNNINDTDAA YELVAEFLPE NAPAVAIVKH ANPCGVATGP 

       310        320        330        340        350        360 
TLAEAYRRAL ACDSVSAFGG VIALNRTLDA ETAEEIVKLF TEVIIAPDVT EEAKSIIARK 

       370        380        390        400        410        420 
PNLRLLAAGG LPDPRAAGLT AKTVSGGLLV QSRDNGMVED LELKVVTKRA PTAQELEDMK 

       430        440        450        460        470        480 
FAFKIAKHVK SNAVIYAKDG QTAGIGAGQM SRVDSARIAA QKAEDAAKAL GLAEPLTRGS 

       490        500        510        520        530 
AVASEAFYPF ADGLLAAIAA GATAVIQPGG SMRDQDVIDA ANEHNVAMVF TGMRHFRH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE007869 Genomic DNA. Translation: AAK88535.2.
PIRAF2923.
F97697.
RefSeqNP_355750.2. NC_003062.2.

3D structure databases

ProteinModelPortalQ8UBM8.
ModBaseSearch...

Protein-protein interaction databases

STRING176299.Atu2823.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1134861.
KEGGatu:Atu2823.
PATRIC20815439. VBIAgrTum91616_2832.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMADLLFAWK.
ProtClustDBPRK00881.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF52335. MGS-like_dom. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_AGRT5
AccessionPrimary (citable) accession number: Q8UBM8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: May 1, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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