Reviewed, UniProtKB/Swiss-Prot Q8UBL6 (DCUP_AGRT5)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Atu2835
ORF Names:	AGR_C_5140

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187578
Regions
	Region	24 – 28	5	Substrate binding By similarity
Sites
	Binding site	43	1	Substrate By similarity
	Binding site	74	1	Substrate By similarity
	Binding site	149	1	Substrate By similarity
	Binding site	204	1	Substrate By similarity
	Binding site	319	1	Substrate By similarity
	Site	74	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8UBL6-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 96351DE3393ECB46	FASTA	344	37,174
	10 20 30 40 50 60 MSERKVMTVL NGKTVTPPPI WLMRQAGRYL PEYRETRKSA GSFLDLCYNP ELASEVTLQP 70 80 90 100 110 120 IRRFGLDAAI LFSDILVIPD ALHRNVSFSE GKGPAMDPID ISGIEKLDAS DVMAHLSPVF 130 140 150 160 170 180 ETVSRLRTSL PDETTLLGFC GAPWTVATYM IAGHGTPDQA PARLFGYQEP AAMEKLLALL 190 200 210 220 230 240 AEVSADYLVA QIDAGADAVQ IFDSWAGVLG EKEFEEYAIK PVARIIASVR ARRPSAKIIA 250 260 270 280 290 300 FAKGAGYLLR DYRRKTGANA IGLDWSVPLS FARDLQKEGP VQGNLDPMLM VAGGKALQDG 310 320 330 340 IDAVLQSLGQ GPLIFNLGHG ITPQADPENV TRLVQRVRSV GGAG

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE007869 Genomic DNA. Translation: AAK88546.1.
PIR	A97699. AB2925.
RefSeq	NP_355761.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPH based on UniProtKB P06132.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UBL6.
Genome annotation databases
GeneID	1134873.
GenomeReviews	Gene locus Atu2835 in contig AE007869_GR.
KEGG	atc:AGR_C_5140. atu:Atu2835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8UBL6.
OMA	VFTKGGG.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_AGRT5

Accession

Primary (citable) accession number: Q8UBL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)