Reviewed, UniProtKB/Swiss-Prot Q8UAW0 (UXUA1_AGRT5)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase 1
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase 1

Gene names

Name:	uxuA1
Ordered Locus Names:	Atu3257
ORF Names:	AGR_L_3119

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Mannonate dehydratase 1 HAMAP MF_00106		PRO_0000170658

Sequences

	Sequence		Length	Mass (Da)
	Q8UAW0-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4C22D27792F37705	FASTA	402	44,690
	10 20 30 40 50 60 MRHTWRWFGP VDKVTVQDAA QAGAEGIVSA LHHITTGDVW PVDEITKRHE AIKAGGLYWD 70 80 90 100 110 120 VVESVPVSED IKTQTGDWKN HIANWQETLR RLSASGIRTV CYNFMPVLDW TRTDLRWETR 130 140 150 160 170 180 HGARAMRFDL TDFAAFDIHI LKRPDAKADY PDWLLEEAAK RFAEMPDTKI AALGRNIGAG 190 200 210 220 230 240 LPGSADGYTL AQLLEKLRSY HGINRGRLQQ NLIDFLSEVT PVAEEVGINI CAHGDDPPWP 250 260 270 280 290 300 LLGLPRILST EADYAHMLSQ VDSRANGVTL CTGSLGARAD NDLPFIAGRF ADRIHFVHLR 310 320 330 340 350 360 NVTRDTDTVP CSFFEDEHLE GGTDMVAVIA ALITEEARRR AEGRDDHTIP MRPDHGQEIL 370 380 390 400 DDLTRGAQPG YPAIGRLKGL AELRGIERTL SHGRFGLATG KG

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007870 Genomic DNA. Translation: AAK90133.1.
PIR	AC2957. C98326.
RefSeq	NP_357348.1.
3D structure databases
SMR	Q8UAW0. Positions 1-391.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UAW0.
Genome annotation databases
GeneID	1135131.
GenomeReviews	Gene locus Atu3257 in contig AE007870_GR.
KEGG	atc:AGR_L_3119. atu:Atu3257.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
PhylomeDB	Q8UAW0.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU3257-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA1_AGRT5

Accession

Primary (citable) accession number: Q8UAW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	June 1, 2002
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)