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Q8UAS9

- THIM_AGRT5

UniProt

Q8UAS9 - THIM_AGRT5

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Protein
Probable hydroxyethylthiazole kinase
Gene
thiM, Atu3288, AGR_L_3060
Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.

Cofactori

Magnesium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Substrate; via amide nitrogen By similarity
Binding sitei125 – 1251ATP By similarity
Binding sitei145 – 1451ATP By similarity
Binding sitei172 – 1721Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAGRO:ATU3288-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:Atu3288
ORF Names:AGR_L_3060
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome linear

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Probable hydroxyethylthiazole kinase
PRO_0000156923Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu3288.

Structurei

3D structure databases

ProteinModelPortaliQ8UAS9.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiENLECEQ.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 2 hits.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 2 hits.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8UAS9-1 [UniParc]FASTAAdd to Basket

« Hide

MSGDFPTAAR AAEILERVRQ MRPRVHCLMN TVVQKFTADG ITVIGGIPSM    50
TTSLEEIESF VTKADALTVN LGTLDAERRR VIRLAIEIAN ASGKPWIVDP 100
VHVDYSPSRL DFARELIAQS PTIVRGNRAE MSLIGDVPDV VRIETGPVDH 150
LRDRTRNVSI VNGHPWMAKV TGTGCLSGGV IAAFMAVEKD ALTAAASALA 200
VTGVSAELAA QRAKGPGTFE PAFLDALSEI SGEDIINHAR IEHEQG 246
Length:246
Mass (Da):26,345
Last modified:June 1, 2002 - v1
Checksum:i27E5AC411493BCAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007870 Genomic DNA. Translation: AAK90102.1.
PIRiAB2961.
D98322.
RefSeqiNP_357317.1. NC_003063.2.

Genome annotation databases

EnsemblBacteriaiAAK90102; AAK90102; Atu3288.
GeneIDi1135162.
KEGGiatu:Atu3288.
PATRICi20816034. VBIAgrTum91616_3129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007870 Genomic DNA. Translation: AAK90102.1 .
PIRi AB2961.
D98322.
RefSeqi NP_357317.1. NC_003063.2.

3D structure databases

ProteinModelPortali Q8UAS9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176299.Atu3288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK90102 ; AAK90102 ; Atu3288 .
GeneIDi 1135162.
KEGGi atu:Atu3288.
PATRICi 20816034. VBIAgrTum91616_3129.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi ENLECEQ.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci AGRO:ATU3288-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 2 hits.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 2 hits.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiTHIM_AGRT5
AccessioniPrimary (citable) accession number: Q8UAS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Has a deletion of about 30 residues in position 132 compared to all other ThiM.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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