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Q8UAS9

- THIM_AGRT5

UniProt

Q8UAS9 - THIM_AGRT5

Protein

Probable hydroxyethylthiazole kinase

Gene

thiM

Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).By similarity

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501Substrate; via amide nitrogenBy similarity
    Binding sitei125 – 1251ATPBy similarity
    Binding sitei145 – 1451ATPBy similarity
    Binding sitei172 – 1721Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAGRO:ATU3288-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable hydroxyethylthiazole kinase (EC:2.7.1.50)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinase
    Short name:
    TH kinase
    Short name:
    Thz kinase
    Gene namesi
    Name:thiM
    Ordered Locus Names:Atu3288
    ORF Names:AGR_L_3060
    OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)
    Taxonomic identifieri176299 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000000813: Chromosome linear

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Probable hydroxyethylthiazole kinasePRO_0000156923Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176299.Atu3288.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8UAS9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiENLECEQ.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 2 hits.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8UAS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDFPTAAR AAEILERVRQ MRPRVHCLMN TVVQKFTADG ITVIGGIPSM    50
    TTSLEEIESF VTKADALTVN LGTLDAERRR VIRLAIEIAN ASGKPWIVDP 100
    VHVDYSPSRL DFARELIAQS PTIVRGNRAE MSLIGDVPDV VRIETGPVDH 150
    LRDRTRNVSI VNGHPWMAKV TGTGCLSGGV IAAFMAVEKD ALTAAASALA 200
    VTGVSAELAA QRAKGPGTFE PAFLDALSEI SGEDIINHAR IEHEQG 246
    Length:246
    Mass (Da):26,345
    Last modified:June 1, 2002 - v1
    Checksum:i27E5AC411493BCAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007870 Genomic DNA. Translation: AAK90102.1.
    PIRiAB2961.
    D98322.
    RefSeqiNP_357317.1. NC_003063.2.

    Genome annotation databases

    EnsemblBacteriaiAAK90102; AAK90102; Atu3288.
    GeneIDi1135162.
    KEGGiatu:Atu3288.
    PATRICi20816034. VBIAgrTum91616_3129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007870 Genomic DNA. Translation: AAK90102.1 .
    PIRi AB2961.
    D98322.
    RefSeqi NP_357317.1. NC_003063.2.

    3D structure databases

    ProteinModelPortali Q8UAS9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176299.Atu3288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK90102 ; AAK90102 ; Atu3288 .
    GeneIDi 1135162.
    KEGGi atu:Atu3288.
    PATRICi 20816034. VBIAgrTum91616_3129.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi ENLECEQ.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci AGRO:ATU3288-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 2 hits.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C58 / ATCC 33970.

    Entry informationi

    Entry nameiTHIM_AGRT5
    AccessioniPrimary (citable) accession number: Q8UAS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Has a deletion of about 30 residues in position 132 compared to all other ThiM.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3