Reviewed, UniProtKB/Swiss-Prot Q8UA46 (UXUA2_AGRT5)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase 2
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase 2

Gene names

Name:	uxuA2
Ordered Locus Names:	Atu3529
ORF Names:	AGR_L_2605

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Mannonate dehydratase 2 HAMAP MF_00106		PRO_0000170659

Sequences

	Sequence		Length	Mass (Da)
	Q8UA46-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4A2278A2032E53E9	FASTA	397	43,649
	10 20 30 40 50 60 MKETWRWFGE SDPITLEHVR QTGASGVVTA LHQIPDGTAW PAEEIAKRKA MIEAAGLEWS 70 80 90 100 110 120 VCESIPMEQS IKRGDADAPK AIARWKDTLS RLGRAGVPVV CYNFMPVVDW TRTNLRWQAR 130 140 150 160 170 180 NTGLALRFEM ADFVAYDVFI LKRIRAAENY DPALVARAEE RFAQMSEDEQ SLLERNIIAG 190 200 210 220 230 240 LPGGALVQTR QSIAALIASF DGIDSATMQG NLLAFLKEVV PVAEEVGVHL GIHPDDPPFS 250 260 270 280 290 300 LFGLPRVVST PADIRAILSA VESPNNGITL CTGSYGARSD NDLVAMAKEF ASRVNFAHLR 310 320 330 340 350 360 NVTVEADGSF FEDDHLDGGA DMIGVIEALL REERSTAKAG RRTNIPMRPD HGHLLGDDIT 370 380 390 KKTNPGYSYI GRMKGLGELR GVIRTIERQL RREEAAA

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE007870 Genomic DNA. Translation: AAK89868.1.
PIR	AG2990. B98293.
RefSeq	NP_357083.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8UA46.
Genome annotation databases
GeneID	1135403.
GenomeReviews	Gene locus Atu3529 in contig AE007870_GR.
KEGG	atc:AGR_L_2605. atu:Atu3529.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8UA46.
OMA	RPDHGHL.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA2_AGRT5

Accession

Primary (citable) accession number: Q8UA46

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)